In this episode of Inside GRAPPA, host Dr. Mio Nakamura (University of Michigan) speaks with Dr. Tina Bhutani-Jacques, MD, MAS, FAAD (Synergy Dermatology / University of California San Francisco) about her groundbreaking study on the role of sleep in psoriasis disease severity. Funded by the GRAPPA Pilot Research Grant, Dr. Bhutani-Jacques’s work is the first prospective cohort study to objectively examine sleep patterns in psoriasis patients.💡 Together, they explore:How a patient’s unexpected experience sparked the idea to investigate sleep and psoriasisThe design and findings of the pilot study using three nights of polysomnography in patients and healthy controlsEarly results showing reduced sleep efficiency, more awakenings, and nearly an hour less sleep per night among psoriasis patientsThe potential link between poor sleep, inflammation, and cardiovascular comorbiditiesPractical advice for clinicians on discussing sleep with psoriasis patientsNext steps, including home-based sleep studies using wearables for more naturalistic data🎧 Tune in for an engaging discussion that highlights how sleep—often overlooked—may be a key factor in understanding psoriatic disease and improving patient outcomes. 🔗 Learn more about GRAPPA’s research initiatives at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
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20:21
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20:21
Shaping the Future: Young GRAPPA Leaders on Mentorship, Collaboration, and Growth
In this episode of Inside GRAPPA, host Dr. Hanna Johnsson spotlights the next generation of leaders in psoriatic disease research through a deep dive into the work of Young GRAPPA---a global, interdisciplinary network within GRAPPA, supporting early-career researchers and clinicians.Joining the conversation are Dr. André L. Ribeiro (Chair, Young GRAPPA, Brazil) and Dr. Gizem Ayan (Chair-Elect, Young GRAPPA, Turkey), who share their personal journeys into leadership and reflect on how mentorship, collaboration, and international networking are transforming opportunities for early-career professionals.💡 Together, they discuss:How Young GRAPPA has grown into a +200-member global network since 2021Projects driving impact, from the Slide Library and Do Not Miss newsletter to international webinars and surveysThe power of mentorship, collaboration, and patient partnership in shaping research prioritiesAdvice for early-career clinicians and researchers eager to get involvedDream collaborations and the importance of saying "yes" to opportunities early🎧 Tune in for a conversation filled with practical advice, inspiration, and an open invitation to join Young GRAPPA in shaping the future of psoriatic disease care.🔗 Learn more and apply to join Young GRAPPA at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
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20:09
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20:09
Patient Research Partners: Elevating Research Through Patient Perspectives
In this special episode of Inside GRAPPA, we delve into the growing impact of the Patient Research Partner (PRP) Network—an essential part of GRAPPA’s mission to integrate the patient voice into scientific research on psoriatic disease.Host Fabian Proft is joined by two influential PRPs: Maarten de Wit from the Netherlands and Suzanne Grieb* from the United States. Together, they explore the critical role of PRPs, the evolution of the network since its inception in 2013, and how these dedicated patient collaborators are shaping treatment guidelines, influencing steering committees, and helping recruit the next generation of partners.What does it really mean to live the principle of “Nothing about us without us”? What kinds of challenges—and transformative insights—do patients bring to the research table? And what can researchers learn from patient partners about improving outcomes, communication, and the research agenda itself?Listen in as we discuss:The origins and global growth of the PRP networkReal-world experiences from PRPs living with psoriatic arthritisHow patients are steering research priorities, not just participating in themStrategies for recruiting and onboarding new patient partnersWhere the network is headed—and how you might get involved🎧 Tune in for a powerful conversation that highlights how experiential knowledge and scientific expertise can—and must—work hand in hand.Subscribe to Inside GRAPPA on your favorite podcast platform.Stay tuned. Stay curious.*Suzanne Grieb is engaged in GRAPPA-related activities as a private consultant or advisor and not in their capacity as a Johns Hopkins faculty member. Hosted on Acast. See acast.com/privacy for more information.
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13:13
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13:13
Defining Difficult-to-Treat and Complex-to-Manage Psoriatic Arthritis
In this compelling episode of Inside GRAPPA, host Dr. Hanna Johnsson, a rheumatologist based in Scotland, leads an important conversation on one of the most pressing issues in psoriatic arthritis (PsA) care: what truly makes a case difficult to treat or complex to manage?Dr. Johnsson is joined by two experts deeply embedded in the GRAPPA initiative to define these concepts:Dr. Fabian Proft, Head of the Division of Rheumatology at Charité Berlin, Germany, and long-time GRAPPA contributor.Dr. Shikha Singla, Assistant Professor of Medicine at the Medical College of Wisconsin, who brings firsthand experience from her combined rheum-derm clinic.Together, they unpack the background, progress, and patient-centered approach of the Difficult-to-Treat (D2T) and Complex-to-Manage PsA Project.✅ HighlightsClearer definitions aim to improve care for patients with persistent symptoms despite treatment“Difficult to treat” focuses on ongoing inflammation; “complex to manage” accounts for non-inflammatory factorsA global literature review revealed inconsistent criteria in defining treatment challengesSurveys of clinicians and patients shaped a more inclusive, consensus-driven frameworkNew definitions to be presented at EULAR—marking a major milestone in PsA research⏱ Timestamps00:00 – Introduction to the episode and today’s topic00:36 – Guest introductions: Dr. Fabian Proft and Dr. Shikha Singla01:00 – Fabian on the need for better definitions and understanding treatment failure04:12 – Defining the terms: inflammation vs. non-inflammatory drivers of disease burden05:15 – Why “complex to manage” is more appropriate than “difficult patient”06:00 – How terminology shapes perceptions and supports more empathetic care06:42 – Scoping literature review: methods and inconsistencies in existing definitions07:57 – Healthcare provider survey: over 200 responses, strong support for two definitions09:12 – Patient survey: nearly 600 responses and insights into global experiences10:21 – Patient-reported challenges: joint pain, fatigue, medication side effects11:54 – Cultural and social factors influencing patient experience12:39 – The Delphi process and achieving expert consensus13:15 – Project milestones: EULAR submission and upcoming publications📚 ResourcesExplore the full scope of this initiative on the GRAPPA D2T PsA Project Page.🔗 Links and Social MediaVisit our Website for more information.Follow us on YouTube, Facebook, and Twitter. Hosted on Acast. See acast.com/privacy for more information.
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14:57
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14:57
Exploring Sex Differences in Psoriatic Arthritis: Biomarkers and Beyond
How do biological sex differences shape the clinical presentation and treatment outcomes in psoriatic arthritis (PsA)? In this episode of Inside GRAPPA, Dr. Hanna Johnsson delves into groundbreaking research led by Steven Dang and Dr. Lihi Eder, supported by the GRAPPA Pilot Research Grant. Their study explores sex-related differences in PsA through proteomic analysis, uncovering unique biomarkers and pathways that could redefine personalized medicine for PsA patients.What You'll Learn:The rationale behind investigating sex-specific differences in PsA. Insights into how immune and inflammatory profiles differ between males and females. Key findings from proteomic studies, including pivotal proteins and pathways like NETosis, Rho GTPase, and cytokine signaling. The potential for sex-specific biomarkers to guide diagnosis and treatment in PsA.🔗 Stay Connected with GRAPPA: Visit the GRAPPA Website for more research updates. Subscribe to Inside GRAPPA wherever you get your podcasts to stay informed on the latest in PsA research. Hosted on Acast. See acast.com/privacy for more information.
Welcome to Inside GRAPPA, a podcast and brought to you by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Our mission is to enhance understanding and treatment of psoriasis and psoriatic arthritis through the sharing of research, knowledge, and collaborative efforts.We bring together leading rheumatologists, dermatologists, scientists, patient representatives, and industry partners, uniting our passions to make a difference for those living with these conditions.Join our host Fabian Proft as we navigate the challenges, share the latest research, and explore the triumphs in the world of psoriasis and psoriatic arthritis. Together, we can make a difference. Hosted on Acast. See acast.com/privacy for more information.
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