NB Hot Topics Podcast

Welcome to the latest Hot Topics podcast from NB Medical with Dr Neal Tucker. Three great pieces of research, all from the New England Journal of Medicine, to discuss today. 
First up. Retatrutide - how effective is this injectable weight-loss medication? Can it help other problems like knee OA and OSA? Is there a downside?
Second, starting statins in the elderly. Is there any benefit in over-70-year-olds?
Third, can the Galleri multi-cancer early detection blood test improve the stage of cancer at diagnosis? We now have strong NHS data, but what does it show? 
References
Retatrutide and weight loss
Retatrutide editorial
STAREE trial
STAREE editorial
NHS Galleri trial
Galleri editorial
www.nbmedical.com/podcast

Welcome to Season 8 of the Hot Topics Podcast from NB Medical with Dr Neal Tucker. Lots of research, as usual, and some future medicine too.
Do NHS health checks actually make a difference, or is it a waste of everybody's time? This month's BJGP has the answer.
From the BMJ this week, which exercises should we recommend to patients (and ourselves...) to maintain bone mineral density and prevent fractures, and how long do we need to exercise for it to make a difference?
And in JAMA, does texting or emailing patients boost statin use in patients who don't really want to take statins, or can we save ourselves some typing?
Finally, in Future Medicine, lipoprotein(a). What is it, why should we care, and what can you do about it?

References
BJGP NHS Health checks and mortality
BMJ Best exercises for BMD
JAMA Statins vs text messages
Lancet Kylo 11 and lipoprotein(a)
www.nbmedical.com/podcast

Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this summer sizzler, we have three new pieces of research for clinicians in general practice. 
First, do antihistamines help with managing atopic eczema, or do they do more harm than good? Does which one we use matter? 
Second, exploring the pain relief achieved by opioids in the short and long term. Are there new lessons to be learned? 
Third, for an alternative way of managing chronic MSK pain, could self-directed CBT be the solution?
References
BMJ Antihistamines and eczema
UK data on use of antihistamines for eczema
Eczema Care Online
BJGP Opioid effects on pain over time
JAMA Self-directed CBT for chronic MSK pain
Podcast on chronic pain with Rangan Chatterjee and Howard Schubiner
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new pieces of research and a special interview later on discussing the recommendations of the National Screening Committee on prostate cancer screening in the UK.
First up for research: nasal sprays versus the common cold. The BJGP reports on longer-term findings through this simple intervention. Can it help this age-old problem?
Second, new kid on the block, orforglipron - could it replace SGLT2 inhibitors for management of type 2 diabetes?
Third, home-based hypnotherapy. Can it help children struggling with functional abdominal pain or IBS? We have a RCT to tell us. 
Finally, our interview with Dr Liz Bancroft, consultant nurse in oncogentics research, and Natalia Norori, interim Head of Data and Evidence at Prostate Cancer UK join us to discuss the new recommendations from the National Screening Programme with targeted screening of men with BRCA2, why they made this recommendation and how this affects us in general practice, plus what we need to know for our patients about the government-backed trial, TRANSFORM.
References
Prostate Cancer UK Information on NSC decision
Prostate Cancer UK Health Professional NSC FAQs
National Screening Committee report on prostate cancer screening
BJGP Nasal sprays for the common cold
Lancet Nasal Sprays original paper
Lancet Orforglipron vs dapagliflozin and T2DM
BJGP Hypnotherapy in children for abdo pain
National Screening Committee report on prostate cancer screening
www.nbmedical.com/podcast

Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. Lots going on in this new episode! 
Three new pieces of research and an interview with Dr Anna Martinez, consultant paediatric dermatologist at GOSH, talking about a skin fragility condition many of us may not have heard of before - epidermolysis bullosa - in conjunction with DEBRA, the leading charity for EB awareness and research. 
In research, we look at two papers published this week in finerenone. Does it have a role in CKD management in patients without diabetes, and if so, how good is it?
Second, retatruide - the latest injectable weight loss medication making a splash across the headlines - could it be used as monotherapy for recent onset type 2 diabetes?
Resources
NB Medical Epidermolysis bullosa free online educational module
DEBRA
NEJM Finerenone for CKD
Lancet Finerenone MA
Lancet Retatrutide for early T2DM
www.nbmedical.com/podcast