The Lancet Gastroenterology & Hepatology in conversation with

Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospital) discusses a large Danish study using phosphatidylethanol (PEth), a direct blood biomarker of recent drinking, showing substantial underestimation and potential reclassification from MASLD to MetALD/ALD.
Click here to read the full article:
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00187-6/fulltext
Medical imaging and theranostics are revolutionising how we diagnose, treat, and understand disease. To meet this moment, The Lancet group is happy to announce the launch of, The Lancet Medical Imaging and Theranostics. 
You can visit https://www.thelancet.com/medical-imaging-theranostics to learn more.
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Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (University of Alberta) unpacks a landmark multicentre trial that tested this hypothesis, and we discuss what it tells us about the role of living organisms in the therapeutic effects of microbiota-based therapies.
Click here to read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00190-6/fulltext
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Do wheat or gluten trigger IBS symptoms? 
We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged adults with IBS—who reported benefit from a gluten-free diet—with wheat, gluten, or a gluten-free sham to test symptom and behavioural responses.
Click here to read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00090-1/fulltext
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Can a multi-metabolite blood test improve early pancreatic cancer detection? We spoke to Julia Mayerle about the METAPAC study, which sought to validate the ability of plasma metabolic signatures to find resectable tumors and reduce unnecessary invasive procedures in high-risk patients.
Read the full article:
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00056-1/fulltext?dgcid=buzzsprout_icw_podcast_June_25_langas
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How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? 
We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents.
Read the full article:
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00006-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas
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