The Lancet Gastroenterology & Hepatology in conversation with

• Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection

  Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (University of Alberta) unpacks a landmark multicentre trial that tested this hypothesis, and we discuss what it tells us about the role of living organisms in the therapeutic effects of microbiota-based therapies.Click here to read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00190-6/fulltextContinue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv

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• Premysl Bercik on a double-blind crossover trial of gluten and wheat in IBS

  Do wheat or gluten trigger IBS symptoms? We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged adults with IBS—who reported benefit from a gluten-free diet—with wheat, gluten, or a gluten-free sham to test symptom and behavioural responses.Click here to read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00090-1/fulltextContinue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv

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• Julia Mayerle on the validation of plasma multimetabolite signatures for patients at risk of or with suspected pancreatic ductal adenocarcinoma

  Can a multi-metabolite blood test improve early pancreatic cancer detection? We spoke to Julia Mayerle about the METAPAC study, which sought to validate the ability of plasma metabolic signatures to find resectable tumors and reduce unnecessary invasive procedures in high-risk patients.Read the full article:https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00056-1/fulltext?dgcid=buzzsprout_icw_podcast_June_25_langasContinue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv

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• Salvatore Piano on the global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis

  How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents.Read the full article:https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00006-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_langasContinue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv

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• John Chia on the ASCOLT trial of adjuvant aspirin for colorectal cancer

  John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients with colorectal cancer.Read the full article:https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00387-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_langasContinue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv

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