EndoDirect - Endocrinologia e Metabologia

Neste FD abordamos resumidamente os principais pontos do guideline de tratamento do diabetes tipo 2 da Sociedade Brasileira de Diabetes atualizado em agosto de 2026.
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Acesse: endodirect.com.br

Neste FD vamos falar sobre a mudança do nome de Síndrome dos Ovários Policísticos para Síndrome Ovariana Metabólica Poliendócrina, sobre o histórico de classificação e sobre os fenótipos da doença.
Acesse a plataforma mais completa em endocrinologia: endodirect.com.br
Referencias:
Teede HJ, Bahri Khomami M, Morman R, Laven JSE, Joham AE, Costello MF, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. Lancet. 2026
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol. 2023Daan NMP, Louwers YV, Koster MPH, Eijkemans MJC, de Rijke YB, Lentjes EWG, et al. Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? Fertil Steril. 2014

Neste FD vamos abordar um tema muito frequente na prática clínica: fadiga associada aos análogos do GLP-1.
Acesse a plataforma mais completa de endocrinologia: endodirect.com.br
Referencias usadas:
Nong K, Shi Q, Xie X, Wang Y, Agarwal A, Guyatt GH, et al. Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis. BMJ. 2026;394:e372161. doi:10.1136/bmj-2026-372161Nie Y, Zhang Y, Liu B, Meng H. Glucagon-like peptide-1 receptor agonists for the treatment of suboptimal initial clinical response and weight gain recurrence after bariatric surgery: a systematic review and meta-analysis. Obes Surg. 2025;35(3):808-22. doi:10.1007/s11695-025-07733-8Mohamad AA. A case report of semaglutide induced sarcopenia: causes of fatigue in older adults. Korean J Fam Med. 2025;46(4):288-91. doi:10.4082/kjfm.25.0008Eldor R, Avraham N, Rosenberg O, Shpigelman M, Golan-Cohen A, Cukierman-Yaffe T, et al. Gradual titration of semaglutide results in better treatment adherence and fewer adverse events: a randomized controlled open-label pilot study. Diabetes Care. 2025;48(9):1607-11. doi:10.2337/dc25-0690

Acesse a plataforma mais completa de endocrinologia: endodirect.com.br

Referências do episódio:Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F. Secondary Osteoporosis. Endocr Rev. 2022Mäkitie O, Zillikens MC. Early-Onset Osteoporosis. CalcifTissue Int. 2022Mancini M, Chapurlat R, Isidor B, et al. Early-OnsetOsteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene. Calcif Tissue Int. 2024Vaucher M, Gonzalez Rodriguez E, Efthymiou A, Sagez J. Mastocytose systémique et impact osseux. Rev Med Suisse

Neste FD discutimos um algoritmo diagnóstico de investigação de pacientes com osteomalacia hipofosfatemica.
Acesse: endodirect.com.br
Referencias: Jan de Beur SM, Minisola S, Xia WB, et al. Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia. J Intern Med. Florenzano P, Cipriani C, Roszko KL, et al. Approach to patients with hypophosphataemia. Lancet Diabetes Endocrinol. 2020;8(2):163-174Haffner D, Emma F, Seefried L, et al. Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia. Nat Rev Nephrol. 2025;21(5):330-354Trombetti A, Al-Daghri N, Brandi ML, et al. Interdisciplinary management of FGF23-related phosphate wasting syndromes: a Consensus Statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia. Nat Rev Endocrinol. 2022;18(6):366-384