GU Cast | Urology Podcast

• ENZA-P Big news Update: LuPSMA and enza improves overall survival

  A breaking news podcast from ASCO GU in San Francisco! Prof Louise Emmett (St Vincent's, Sydney), has just read out the latest update from the ENZA-P trial (and simultaneous publication in Lancet Oncology), reporting that the combination of LuPSMA and enzalutamide improves overall survival when compared with enzalutamide alone, in men with poor prognosis mCRPC. Big news!! A 45% reduction in the risk of death in favour of the combination. Plus excellent quality of life for those receiving the combo. We are joined by Louise and co-author A/Prof Andrew Weickhardt (Austin Health, Melbourne), to discuss this exciting data from the ENZA-P trial, and what it means for the future of not just mCRPC, but also for similar combinations in mHSPC.ENZA-P is an investigator-initiated Phase II trial led by ANZUP in partnership with the Prostate Cancer Research Alliance, a join initiative between the Australian Government and Movember. Your co-hosts as ever are Professor Declan Murphy and Dr Renu Eapen. This is a Themed podcast supported by our Gold Partners, Astellas, and our Silver Partners, Novartis. Even better on our YouTube channelLinks:Lancet Oncology paperANZUP 

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• Future-gazing radioligand therapy in prostate cancer | With Oliver Sartor and Michael Hofman

  Look who popped into the GU Cast studio this week for a chat about where we are going next with radioligand therapy (RLT) for prostate cancer! Professors Oliver Sartor (Mayo Clinic, Rochester) and Michael Hofman (Peter Mac, Melbourne), are two of the world's most pre-eminent experts in the world of RLT for prostate cancer. They were each respectively PIs  on the VISION and TheraP RCTs published in NEJM and Lancet in 2021, and both have many ongoing trials in RLT for prostate cancer. We hear in which stages of prostate cancer LuPSMA is next likely to be approved, and some discussion about exciting trials soon to read out. We also discuss other RLTs including actinium and terbium, combinations, imaging technology for patient selection, AI, and the word "cure" even gets a mention. A very entertaining and exciting discussion with two of the best in the business. Your regular hosts are Professor Declan Murphy and Dr Renu Eapen, Urologists at Peter MacCallum Cancer Centre, Melbourne.This is a Themed Podcast supported by our Silver Partners, Novartis. Even better on our YouTube channelLinks:Michael's paper in the Journal of Nuclear Medicine:"The Hierarchy of SUVs: From Diagnostics to Therapeutics and the Pathway to Effective Theranostics"

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• Toni's Legendary Top 10 Papers List!

  Dr Toni Choueiri, Chief of GU Oncology at Dana-Farber Cancer Institute (Boston, USA) returns to GU Cast with members of his team at Dana Farber Cancer Institute to discuss our favourite lists of top GU Oncology papers for 2024. Toni has posted these now legendary lists at the end of each year on Twitter/X since the start of Covid, and they have become essential reading for anyone wanting a superb overview of top trials. Each tweet contains a top line summary of each trial and key images such as K-M curves, plus links to the original papers. A huge amount of work and a great resource. Today we are joined by Toni along with Dr Marc Eid and Dr Emre Yekeduz who helped compile this year's lists. We hear about the process behind it all, and we run through their Top 10 Bladder and Renal Cancer papers, and their Top 5 Prostate Cancer papers. The team also post their Top 10 Translational papers and Their Top 10 non-GU Oncology papers. Well done again to Toni, Marc, Emre and team! Links to the tweets below. Even better on our YouTube channelLinks:Top 10 Bladder and Renal Cancer Papers Top 5 Prostate Cancer Papers 

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• Shanghai GU Oncology Highlights Part 2

  Part 2 of our GU Cast Conference Highlights from Shanghai including discussions with Dr Stephen Freedland (Los Angeles), Dr Liang Liang (Shaanxi), Dr Andrea Necchi (Milano), Dr Xiaojie Bian (Shanghai), and Dr Hongkai Wang (Shanghai).  Declan Murphy travelled to Shanghai for the 14th GU Oncology Academic Meeting hosted by Fudan University Shanghai Cancer Centre, and to meet up with our GU Cast China Editor, Dr Yao Zhu. This is an excellent meeting in one of our very favourite cities. In Part 1 we spoke to Conference Chair, Dr Dingwei Ye, Dr Karim Fizazi, Dr Peng Wu, and Dr Axel Merseburger, to overview the latest stories in GU Oncology. Special thanks to our Conference Highlights Partner, Bayer China, who set up an amazing GU Cast studio for us in Shanghai. Thanks to Hexun and all the local Bayer team in China.  Also available as an audio podcast - just search GU Cast wherever you get your podcasts

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• Shanghai GU Oncology Highlights Part 1

  Declan Murphy travels to Shanghai for the 14th GU Oncology Academic Meeting hosted by Fudan University Shanghai Cancer Centre, and to meet up with our GU Cast China Editor, Dr Yao Zhu. This is an excellent meeting in one of our very favourite cities, and this year Declan joins International Faculty including Dr Stephen Freedland (Los Angeles), Dr Karim Fizazi (Paris), Dr Axel Merseburger (Lubeck). and Dr Andrea Necchi (Milano) to overview the latest stories in GU Oncology. Top Chinese experts from across the country also join and the meeting includes some landmark consensus statements from multidisciplinary panels.Today we post Part 1 of our GU Cast Conference Highlights from Shanghai including discussions with Conference Chair, Dr Dingwei Ye, Dr Karim Fizazi, Dr Peng Wu, and Dr Axel Merseburger. Special thanks to our Conference Highlights Partner, Bayer China, who set up an amazing GU Cast studio for us in Shanghai. Thanks to Hexun and all the local Bayer team in China. Even better on our YouTube channel 

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