MDS Podcast

Dr. Sarah Camargos is joined by Dr. Rajeev Kumar to explore early research on targeting neuroinflammation in Huntington's disease. Dr. Kumar delves into the intricacies of the complement cascade, highlighting the pivotal role of C1q as the recognition molecule at the top of this immune system chain reaction and how ANX005 aims to prevent the initiation of the cascade. He further discusses the implications of biomarker advancements and safety protocols in moving towards more effective treatments for Huntington's disease.

Read the article.

Journal CME is available until June 30, 2027.

Dr. Sarah Camargos is joined by Dr. Rajeev Kumar to explore early research on targeting neuroinflammation in Huntington's disease. Dr. Kumar delves into the intricacies of the complement cascade, highlighting the pivotal role of C1q as the recognition molecule at the top of this immune system chain reaction and how ANX005 aims to prevent the initiation of the cascade. He further discusses the implications of biomarker advancements and safety protocols in moving towards more effective treatments for Huntington's disease.

Read the article.

Journal CME is available until June 30, 2027.

Ms. Nicole Duff and Prof. Hae-Young Hawong discuss the benefits of Argentine tango in the rehabilitation of person's with Parkinson disease. The motor, non-motor, social, and quality of life gains are all explored; in addition to, the neuro-anatomical, neurophysiological and neuroplastic benefits. Prof. Hawong also describes the very successful and passion-based Argentine tango program she has established at the Yale School of Medicine.

Dr. Norihito Uemura joins Prof. Tiago Outeiro to discuss perampanel, an AMPA receptor antagonist, and how it has been shown to block alpha-synuclein propagation and neurodegeneration in a mouse model of Lewy body disease. Dr. Uemura explains the mechanistic findings of transsynaptic propagation and the study limitations pertaining to mouse behavior. They also discuss perampanel’s established therapeutic ranges in epilepsy, review limited prior Parkinson’s data, and outline next steps including a potential clinical trial in Parkinson’s disease patients. Read article. Journal CME is available until June 5, 2027.

Ms. Nicole Duff and Dr. Marjan Meinders discuss end of life preferences of people with Parkinson’s disease. Together they discuss the ways that end-of-life records could be sourced, as well as what information could be found in the end-of-life record. They further dive into the differences between specific European countries and the reasons around the low rate of end-of-life records for people with Parkinson's disease.