All-In with Chamath, Jason, Sacks & Friedberg

(0:00) Martin Shkreli joins the Besties!
(0:55) Why quantum computing is a one-trick business and why he's betting against it
(7:42) The drugs big pharma sells too cheap and his journey from hedge fund trader to pharma
(11:37) AI, drug discovery, and who actually wins
(21:32) Brilliance and rule-breaking, the gifted-kid trap & what prison taught him
 
Thanks to our partners for making this possible!
 
IREN is a vertically integrated AI Cloud platform, delivering data centers, compute and software for AI training and inference. https://iren.com/
 
Oracle connects the data, applications, and infrastructure that turn AI into business outcomes—with the flexibility, choice, and control to optimize as AI evolves. http://oracle.com/ai
EY helps tech innovators scale from startup to exit to megacap. You build the future. We'll handle the rest. http://www.ey.com
 
Meta believes the future is for everyone. We're focused on giving every person the tools to reach their full potential and making sure the benefits of technology are distributed to all. http://www.meta.com
 
Keel Infrastructure owns the power, land, and connectivity that HPC and AI run on - backed by secured energy assets and established grid interconnections across North America. https://keelinfra.com/
 
Airwallex - Agentic Global Business Accounts. Open local accounts in 70+ countries to accept payments, earn yield, pay globally, and manage spend. http://airwallex.com
 
PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure, PayPal empowers consumers and businesses in approximately 200 markets to join and thrive in the global economy. For more information, visit https://www.paypal.com
 
Google for Startups connects founders with the right people, products, and best practices to help startups build faster and go further. https://startup.google.com/
 
Explore ideas, industries, and technologies worth understanding with Chamath every week on Learn with Me: https://research.socialcapital.com/allin
 
Follow the besties: 
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Intro Music Credit:
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https://x.com/yung_spielburg
 
#allin #tech #news

(0:00) Bestie intros!
(2:53) Anthropic believes Claude might be conscious: a new religion? Lobbying the Pope, alignment risks, model welfare
(38:28) OpenAI's math breakthroughs and community backlash
(1:02:03) Riots in France, Friedberg's socialism metric, bond market
(1:21:41) Grok Bot goes headless, OpenAI launches Dots, is IP worthless?
Follow the besties:
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https://x.com/Jason
https://x.com/DavidSacks
https://x.com/friedberg
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Follow on Instagram:
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Intro Music Credit:
https://rb.gy/tppkzl
https://x.com/yung_spielburg
Intro Video Credit:
https://x.com/TheZachEffect
Referenced in the show:
https://www.nytimes.com/2026/09/29/us/anthropic-claude-morals-ai.html
https://www.anthropic.com/constitution
https://x.com/andrewcurran_/status/2108244808494154089
https://www.economist.com/the-world-in-brief/2026/10/03/388af69b-8327-40a3-af5a-13c0ede56800
https://www.lesswrong.com/users/eliezer_yudkowsky
https://www.amazon.com/Anyone-Builds-Everyone-Dies-Superhuman/dp/0316595640
https://en.wikipedia.org/wiki/Roko%27s_basilisk
https://www.nytimes.com/2026/10/06/science/openai-math-problems.html
https://www.scientificamerican.com/article/openai-unleashes-hundreds-more-math-results-upon-a-field-already-in-shock/
https://terrytao.wordpress.com/2026/10/07/ahm-statement-on-openais-october-6-release-of-mathematical-documents
https://scottaaronson.blog/?p=10169
https://x.com/imjustnewatai/status/2107601711032373333
https://x.com/skdh/status/2107848423726555204
https://x.com/friedberg/status/2107856770609844491
https://www.dw.com/en/france-trade-unions-join-students-in-major-demonstration/a-79560273
https://www.nytimes.com/2026/10/02/world/europe/france-schools-protests-unrest.html
https://www.nytimes.com/2026/10/08/business/france-bond-yields.html
https://x.com/LucAuffret/status/2108217923101683737
https://polymarket.com/event/next-french-presidential-election
https://polymarket.com/event/another-fed-rate-hike-in-2026
https://x.com/nikitabier/status/2108262529571144176

(0:00) Bestie intros!
(2:01) Trump's Super Intelligence Summit: Behind the scenes and how the accord was created and signed
(17:57) Cybersecurity arms race, data center national security, America.gov, coordinated doomer messaging
(45:22) Recent economic data: GDP, jobs, diesel, inflation, rates, manufacturing, poverty, and more
(1:00:24) Midterm predictions, 2028 look ahead
(1:09:28) Media coverage of attempted terrorist hijacking
Follow the besties:
https://x.com/chamath
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Follow on X:
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Follow on Instagram:
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Intro Music Credit:
https://rb.gy/tppkzl
https://x.com/yung_spielburg
Intro Video Credit:
https://x.com/TheZachEffect
Referenced in the show:
https://x.com/WhiteHouse/status/2105292669303791687
https://www.wsj.com/economy/the-ai-build-out-is-becoming-the-biggest-economic-bet-in-u-s-history-c60716dd
https://www.reuters.com/world/us/us-second-quarter-gdp-revised-higher-amid-robust-consumer-spending-2026-09-30
https://www.atlantafed.org/research-and-data/data/gdpnow
https://www.bls.gov/opub/ted/2026/payroll-employment-rose-162000-in-august-2026.htm
https://www.wsj.com/opinion/u-s-economy-gdp-commerce-upward-revision-aee8692e
https://www.investing.com/news/economic-indicators/chicago-pmi-surges-signals-robust-manufacturing-expansion-93CH4925362
https://www.reuters.com/markets/us/us-inflation-rises-less-than-expected-august-consumer-spending-surges-2026-09-30
https://www.theguardian.com/business/2026/oct/01/crude-oil-exports-strait-of-hormuz-transport-gulf-region-diesel
https://polymarket.com/predictions/midterms
https://x.com/OliaOnX/status/2105333178814832963
https://x.com/NYTimesPR/status/2105328158379856153

(0:00) Jake Paul joins the Chamath!
(6:41) Turning an audience into businesses, the boxing playbook & coming for the UFC
(11:54) Attention as capital, investing without the celebrity label & why politics is next
(20:46) Drew Taggart & Alex Pall join the Besties!
(30:35) From artists to investors: picking deals, playing the sixth man & what fame buys
(37:33) Advice for famous investors, whether fame helps or hurts & the non-obvious bets
(46:10) Riding winners, getting cash back to investors & spotting bubble behavior
 
Thanks to our partners for making this possible!
IREN is a vertically integrated AI Cloud platform, delivering data centers, compute and software for AI training and inference. https://iren.com/
Oracle connects the data, applications, and infrastructure that turn AI into business outcomes—with the flexibility, choice, and control to optimize as AI evolves. http://oracle.com/ai
EY helps tech innovators scale from startup to exit to megacap. You build the future. We'll handle the rest. http://www.ey.com
Meta believes the future is for everyone. We're focused on giving every person the tools to reach their full potential and making sure the benefits of technology are distributed to all. http://www.meta.com
Keel Infrastructure owns the power, land, and connectivity that HPC and AI run on - backed by secured energy assets and established grid interconnections across North America. https://keelinfra.com/
Airwallex - Agentic Global Business Accounts. Open local accounts in 70+ countries to accept payments, earn yield, pay globally, and manage spend. http://airwallex.com
PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure, PayPal empowers consumers and businesses in approximately 200 markets to join and thrive in the global economy. For more information, visit https://www.paypal.com
Google for Startups connects founders with the right people, products, and best practices to help startups build faster and go further. https://startup.google.com/
Explore ideas, industries, and technologies worth understanding with Chamath every week on Learn with Me: https://research.socialcapital.com/allin
 
Follow the besties: 
https://x.com/chamath
https://x.com/Jason
https://x.com/DavidSacks
https://x.com/friedberg
 
Follow on X:
https://x.com/theallinpod
 
Follow on Instagram:
https://www.instagram.com/theallinpod
 
Follow on TikTok:
https://www.tiktok.com/@allin
 
Follow on LinkedIn: 
https://www.linkedin.com/company/allinpod
 
Intro Music Credit:
https://rb.gy/tppkzl
https://x.com/yung_spielburg
 
#allin #tech #news

(0:00) Daniel Ek joins the Besties!
(1:14) Starting Spotify: Beating piracy and betting his own money on the record labels
(6:10) Neko Health: The Spotify playbook for healthcare, the $499 body scan, and why US healthcare waits until you're sick
(36:04) AI: Tech's failure to sell the upside, open vs. closed models, and regulating compute
(44:24) Back to Spotify: Podcasting's open standards and the Stardoll origin story



Thanks to our partners for making this possible!
 
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Follow the besties: 
https://x.com/chamath
https://x.com/Jason
https://x.com/DavidSacks
https://x.com/friedberg
 
Follow on X:
https://x.com/theallinpod
 
Follow on Instagram:
https://www.instagram.com/theallinpod
 
Follow on TikTok:
https://www.tiktok.com/@allin
 
Follow on LinkedIn: 
https://www.linkedin.com/company/allinpod
 
Intro Music Credit:
https://rb.gy/tppkzl
https://x.com/yung_spielburg
 
Intro Video Credit:
https://x.com/TheZachEffect
 
#allin #tech #news