"The Cognitive Revolution" | AI Builders, Researchers, and Live Player Analysis

• Don't Make Mirror Life: Synthetic Biologist Kate Adamala on Risks & Responsibility

  In this episode of The Cognitive Revolution, University of Minnesota Professor of Genetics and Synthetic Biologist, Kate Adamala, offers insights into synthetic biology and its potential implications for humanity. The discussion begins with an overview of synthetic biology and its goal to expand the chemical repertoire of life. Adamala delves into 'mirror life'—biological systems made of mirror-image molecules—and the significant risks they pose. She highlights parallels to AI safety concerns and emphasizes the importance of containing groundbreaking technologies to avoid unintended consequences. Adamala recounts her journey from advocating for mirror life to leading an effort to prevent its development, stressing the need for responsible innovation. The episode concludes with reflections on maximizing benefits while minimizing risks in both synthetic biology and AI. SPONSORS: Oracle Cloud Infrastructure: Oracle Cloud Infrastructure (OCI) is the next-generation cloud platform that delivers better, cheaper, and faster solutions for your infrastructure, database, application development, and AI needs. Experience up to 50% savings on compute, 70% on storage, and 80% on networking with OCI's high-performance environment—try it for free with zero commitment at https://oracle.com/cognitive The AGNTCY: The AGNTCY is an open-source collective dedicated to building the Internet of Agents, enabling AI agents to communicate and collaborate seamlessly across frameworks. Join a community of engineers focused on high-quality multi-agent software and support the initiative at https://agntcy.org/?utm_campaign=fy25q4_agntcy_amer_paid-media_agntcy-cognitiverevolution_podcast&utm_channel=podcast&utm_source=podcast NetSuite by Oracle: NetSuite by Oracle is the AI-powered business management suite trusted by over 41,000 businesses, offering a unified platform for accounting, financial management, inventory, and HR. Gain total visibility and control to make quick decisions and automate everyday tasks—download the free ebook, Navigating Global Trade: Three Insights for Leaders, at https://netsuite.com/cognitive Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive PRODUCED BY: https://aipodcast.ing SOCIAL LINKS: Website: https://www.cognitiverevolution.ai Twitter (Podcast): https://x.com/cogrev_podcast Twitter (Nathan): https://x.com/labenz LinkedIn: https://linkedin.com/in/nathanlabenz/ Youtube: https://youtube.com/@CognitiveRevolutionPodcast Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431 Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

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  2:03:21
• What did Google's AI Co-Scientist "Discover"? The Human Scientists' POV, from the Podovirus podcast

  We're following up on our recent episode on Google's AI Co-Scientist with a special crossover episode from the Podovirus podcast. Hosts Dr Jessica Sacher and Dr Joe Campbell speak with José Penadés and Tiago Costa, scientists at Imperial College London who made a surprising discovery that Google's AI Co-Scientist later put forward as a hypothesis entirely on its own. The episode explores the fascinating world of bacteriophages (viruses that infect bacteria) and phage-inducible chromosomal islands (PICIs) - DNA sequences that hijack virus reproduction to spread themselves as a bacterial defense mechanism. The key mystery was how capsid-forming PICIs, which only encode virus heads without tails, managed to spread across different bacteria. The surprising answer, which eluded human scientists for years but which Google's AI Co-Scientist discovered through literature analysis, is that these capsids evolved to connect with various virus tails in the environment. This episode demonstrates how AI can now contribute to frontier scientific research beyond just grunt work - providing unbiased perspectives and key insights that accelerate discovery. It's a vivid example of science fiction becoming reality in our lifetimes. SPONSORS: Oracle Cloud Infrastructure: Oracle Cloud Infrastructure (OCI) is the next-generation cloud platform that delivers better, cheaper, and faster solutions for your infrastructure, database, application development, and AI needs. Experience up to 50% savings on compute, 70% on storage, and 80% on networking with OCI's high-performance environment—try it for free with zero commitment at https://oracle.com/cognitive NetSuite by Oracle: NetSuite by Oracle is the AI-powered business management suite trusted by over 41,000 businesses, offering a unified platform for accounting, financial management, inventory, and HR. Gain total visibility and control to make quick decisions and automate everyday tasks—download the free ebook, Navigating Global Trade: Three Insights for Leaders, at https://netsuite.com/cognitive Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive PRODUCED BY: https://aipodcast.ing CHAPTERS: (00:00) About the Episode (04:37) Welcome to Podovirus Podcast (04:58) Introducing the Special Guests and Topic (06:30) Exploring Mobile Genetic Elements (13:20) The Role of AI in Phage Research (16:48) Mechanisms of Gene Transfer (Part 1) (20:10) Sponsors: Oracle Cloud Infrastructure | NetSuite by Oracle (22:43) Mechanisms of Gene Transfer (Part 2) (23:36) Insights and Discoveries (28:45) Future Directions and Applications (Part 1) (32:35) Sponsors: Shopify (34:32) Future Directions and Applications (Part 2) (41:22) Unbiased Systems and Conjugation (42:35) Google's Excitement and Experimental Evidence (45:39) Benchmarking AI Systems (49:29) Manuscript Revisions and Future Plans (51:53) AI as a Collaborator in Scientific Research (54:52) Challenges and Hypotheses in Phage Biology (57:58) Future of AI in Scientific Research (01:05:52) Concluding Thoughts and Future Collaborations (01:12:07) Outro

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  1:14:14
• Mechanistic Interpretability: Philosophy, Practice & Progress with Goodfire's Dan Balsam & Tom McGrath

  In this episode, Daniel Balsam and Tom McGrath, at Goodfire, discuss the future of mechanistic interpretability in AI models. They explore the fundamental inputs like models, compute, and algorithms, and emphasize the importance of a rich empirical approach to understanding how models work. Balsam and McGrath provide insights into ongoing projects and breakthroughs, particularly in scientific domains and creative applications, as they aim to push the frontiers of AI interpretability. They also discuss the company's recent funding and their goal to advance interpretability as a critical area in AI research. SPONSORS: Box Report: AI is delivering truly measurable productivity — strategic companies are already turning a 37% productivity edge. Discover how in Box’s new 2025 State of AI in the Enterprise Report — read the full report here: https://bit.ly/43uVP52 Oracle Cloud Infrastructure (OCI): Oracle Cloud Infrastructure offers next-generation cloud solutions that cut costs and boost performance. With OCI, you can run AI projects and applications faster and more securely for less. New U.S. customers can save 50% on compute, 70% on storage, and 80% on networking by switching to OCI before May 31, 2024. See if you qualify at https://oracle.com/cognitive ElevenLabs: ElevenLabs gives your app a natural voice. Pick from 5,000+ voices in 31 languages, or clone your own, and launch lifelike agents for support, scheduling, learning, and games. Full server and client SDKs, dynamic tools, and monitoring keep you in control. Start free at https://elevenlabs.io/cognitive-revolution NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive PRODUCED BY: https://aipodcast.ing SOCIAL LINKS: Website: https://www.cognitiverevolution.ai Twitter (Podcast): https://x.com/cogrev_podcast Twitter (Nathan): https://x.com/labenz LinkedIn: https://linkedin.com/in/nathanlabenz/ Youtube: https://youtube.com/@CognitiveRevolutionPodcast Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431 Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

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  1:52:52
• The Perfect Substrate for AGI, with Replit CEO Amjad Masad

  In this episode of The Cognitive Revolution, Amjad Masad , founder and CEO of Replit, discusses the fast-paced growth of Replit, the concept of 'vibe coding', and the challenges and opportunities in the rapidly evolving AI-assisted coding space. He shares insights into Replit's competitive advantages, known as 'moats', and how they maintain their lead through innovation and excellence in execution. The conversation delves into the architectural complexities of building AI agents, their autonomy, and the practical implications for businesses. Amjad touches upon the potential and limitations of current AI models, the future of general intelligence, and the preparation needed for potential AI advancements. He also highlights the importance of intuitive user interfaces for AI-driven software development and the critical role of human-like interaction with AI agents. Upcoming Major AI Events Featuring Nathan Labenz as a Keynote Speaker: ⁠https://www.imagineai.live/⁠ ⁠https://adapta.org/adapta-summit⁠ ⁠https://itrevolution.com/product/enterprise-tech-leadership-summit-las-vegas/ SPONSORS: ElevenLabs: ElevenLabs gives your app a natural voice. Pick from 5,000+ voices in 31 languages, or clone your own, and launch lifelike agents for support, scheduling, learning, and games. Full server and client SDKs, dynamic tools, and monitoring keep you in control. Start free at https://elevenlabs.io/cognitive-revolution Oracle Cloud Infrastructure (OCI): Oracle Cloud Infrastructure offers next-generation cloud solutions that cut costs and boost performance. With OCI, you can run AI projects and applications faster and more securely for less. New U.S. customers can save 50% on compute, 70% on storage, and 80% on networking by switching to OCI before May 31, 2024. See if you qualify at https://oracle.com/cognitive The AGNTCY: The AGNTCY is an open-source collective dedicated to building the Internet of Agents, enabling AI agents to communicate and collaborate seamlessly across frameworks. Join a community of engineers focused on high-quality multi-agent software and support the initiative at https://agntcy.org/?utm_campaign=fy25q4_agntcy_amer_paid-media_agntcy-cognitiverevolution_podcast&utm_channel=podcast&utm_source=podcast Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive PRODUCED BY: https://aipodcast.ing

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  1:01:16
• The RAISE Act: Minimum Standards for Frontier AI Development, with NY Assembly Member Alex Bores

  In this episode, New York State Assembly Member Alex Bores discusses the RAISE Act, a proposed bill aimed at regulating frontier AI models with basic safety protocols. He explains his background in technology, his motivations for the bill, and the legislative process. He emphasizes the importance of having clear safety protocols, third-party audits, and whistleblower protections for AI developers. He explains the intricacies of the bill, including its focus on large developers and frontier models, and addresses potential objections related to regulatory capture and state-level legislation. Alex encourages public and industry input to refine and support the bill, aiming for a balanced approach to AI regulation that keeps both innovation and public safety in mind. Link to the RAISE bill: https://legislation.nysenate.gov/pdf/bills/2025/A6453 Link to support Raise bill: https://win.newmode.net/aisafetynewyork Link to support AI Transparency Legislation: https://docs.google.com/forms/d/e/1FAIpQLSdvpAHkAWiA38oIu1cp57azchPqOOoxb789tHQ896ikJf3CKg/viewform Upcoming Major AI Events Featuring Nathan Labenz as a Keynote Speaker ⁠https://www.imagineai.live/⁠ ⁠https://adapta.org/adapta-summit⁠ ⁠https://itrevolution.com/product/enterprise-tech-leadership-summit-las-vegas/ SPONSORS: ElevenLabs: ElevenLabs gives your app a natural voice. Pick from 5,000+ voices in 31 languages, or clone your own, and launch lifelike agents for support, scheduling, learning, and games. Full server and client SDKs, dynamic tools, and monitoring keep you in control. Start free at https://elevenlabs.io/cognitive-revolution Oracle Cloud Infrastructure (OCI): Oracle Cloud Infrastructure offers next-generation cloud solutions that cut costs and boost performance. With OCI, you can run AI projects and applications faster and more securely for less. New U.S. customers can save 50% on compute, 70% on storage, and 80% on networking by switching to OCI before May 31, 2024. See if you qualify at https://oracle.com/cognitive The AGNTCY: The AGNTCY is an open-source collective dedicated to building the Internet of Agents, enabling AI agents to communicate and collaborate seamlessly across frameworks. Join a community of engineers focused on high-quality multi-agent software and support the initiative at https://agntcy.org/?utm_campaign=fy25q4_agntcy_amer_paid-media_agntcy-cognitiverevolution_podcast&utm_channel=podcast&utm_source=podcast Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive PRODUCED BY: https://aipodcast.ing

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  1:43:36

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