Six O'Clock News

Iran has fired hundreds of missiles and drones at targets across the Middle East, after announcing that its Supreme Leader, Ayatollah Ali Khamenei, has been killed in US-Israeli attacks. At least 200 people -- most of whom were at a girls' school in the country's south -- have been reported killed in Iran. Three US service personnel have been killed in Iran's response, as well as ten people in Israel. Donald Trump has suggested that Iran's new leadership wanted to talk. Meanwhile, UK government officials are understood to be working on plans to potentially evacuate British nationals from the Middle East.

Iran has launched a wave of retaliatory strikes against Israel, and American allies across the Middle East - following this morning's joint attack by Israel and the US. President Trump has urged Iranians to use the attacks as an opportunity to rise up against their country's regime.Air raid sirens have been heard across Israel, after the launch of Iranian missiles towards the country. And: The Labour MP, Josh Simons, has resigned as a Cabinet Office Minister, saying he had become a distraction from the government's work. He's been under scrutiny because of claims the think tank he previously ran -- called Labour Together -- commissioned a report looking into the background of journalists.

Sir Keir Starmer has vowed to keep fighting, after Labour finished behind the Green Party and Reform UK in the Gorton and Denton by-election. Also: The former US President, Bill Clinton, gives evidence under oath to a congressional committee, about his past links with the sex offender Jeffrey Epstein. And over fishing means mackerel stocks are running low in the seas and on the shelves.

Instagram is to start notifying parents if their teenage children search repeatedly for content related to self-harm or suicide. Also: Jersey has voted to legalise assisted dying for terminally ill people. And the number of people sleeping rough in England reaches a record high.

The Metropolitan Police has apologised for inadvertently revealing that Sir Lindsay Hoyle told its officers Lord Mandelson was considering leaving the country. Also: The government insists it's going ahead with its deal to transfer the Chagos Islands to Mauritius, despite a minister telling Parliament it was on hold. And satellite images of penguin moulting sites highlight the dangers to the birds of climate change.