The Human Upgrade: Biohacking for Longevity & Performance

https://truedark.com/discount/DAVETUBE

Most people believe testosterone declines simply because of age. That explanation is easy, familiar, and wrong. Testosterone is not primarily controlled by how hard you train, how clean you eat, or how stressed you feel during the day.

It is controlled by what happens in your brain at night. This video explains how sleep architecture works, why deep sleep is the foundation of hormone production, and how common nighttime habits flatten testosterone signals at the source.

It also walks through practical ways to restore proper sleep timing, protect deep sleep, and rebuild the hormonal rhythm the body depends on.

Timestamps:
00:00 - Why testosterone decline is not just about aging
01:12 - When testosterone is actually made in the body
01:37 - Deep sleep explained (slow-wave sleep / N3)
02:14 - “Fake aging”: why you feel older than you are
03:35 - Why 8 hours of sleep can still fail you
05:39 - How to protect deep sleep
09:45 - How light at night confuses your brain’s clock
12:11 - How to protect your eyes and sleep at night
14:20 - What happens when sleep is finally fixed

Thank you to our sponsors!
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Resources:
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode covers:

• Mic-628 Could Reset Your Body Clock and Cut Jet Lag in Half
A new circadian drug candidate, Mic-628, has demonstrated the ability to shift the body’s internal clock and significantly reduce jet-lag recovery time in early human studies. In controlled simulations, participants experienced faster realignment of their sleep-wake cycles and improved daytime performance compared to standard approaches like melatonin and light timing alone. Dave explains how this compound targets a core clock pathway, why eastbound travel is biologically harder than westbound, and how pharmacologic chronotherapy could become a serious performance tool for frequent travelers and shift workers. He also connects circadian alignment to obesity, insulin resistance, cardiovascular risk, and cognitive decline, outlining what this breakthrough could mean if safety data continues to hold.
• Source: https://www.sciencedaily.com/news/top/

• Late-Life Depression May Signal Parkinson’s or Dementia
New research from Shanghai Jiao Tong University found that new-onset depression in older adults is strongly associated with increased risk of Parkinson’s disease and dementia. Dave reframes this finding as a brain health signal rather than a purely psychiatric issue, explaining how inflammation, microglial activation, vascular health, and neurodegeneration intersect with mood changes. He breaks down why sudden depression in someone with no prior history may warrant deeper cognitive testing, sleep evaluation, and metabolic screening instead of simply prescribing an antidepressant and moving on. This story highlights the importance of treating mood shifts as early biological data in a longevity framework.
• Source: https://www.sciencedaily.com/releases/2026/02/260210040623.htm

• Speed-Training Brain Games Reduced Dementia Risk by 25 Percent
The long-running NIH-funded ACTIVE trial found that a specific speed-of-processing training program reduced dementia incidence by roughly 25 percent over two decades. Unlike memory or reasoning exercises, this visual processing speed protocol produced measurable long-term protection. Dave explains why reaction time and processing speed may be core capacities tied to cognitive resilience, and how structured brain-training programs descended from this research can be treated like strength training for the mind. Instead of vague advice to “stay mentally active,” this data supports building deliberate, trackable cognitive training into a midlife longevity plan.
• Sources:
– NPR summary: https://www.npr.org/2026/02/09/nx-s1-5702423/modest-mental-exercise-can-reduce-risk-of-dementia-for-decades-study-finds
– Psychology Today analysis: https://www.psychologytoday.com/us/blog/build-your-brain/202602/new-study-means-the-age-of-dementia-prevention-begins-now

• Moderate Coffee Intake Linked to Slower Brain Aging
A large analysis of roughly 130,000 participants found that moderate coffee consumption, about one to three cups daily, was associated with markers of slower brain aging and lower dementia risk. Dave explains why moderate, morning-weighted caffeine intake may align acute performance benefits with potential long-term brain protection. He breaks down the dose curve, why more is not necessarily better, and how to use coffee strategically without compromising sleep or circadian rhythm. Rather than framing caffeine as either a miracle or a villain, this study supports intelligent, personalized dosing as part of a broader brain-health stack.
• Source: https://www.nature.com/articles/d41586-026-00409-y

• Kratom Crackdowns and the Future of Supplement Freedom
Regulators are tightening restrictions on high-potency kratom derivatives such as 7-hydroxymitragynine, with new bans and stricter warning requirements emerging at the state level. The FDA continues to treat kratom and its concentrated derivatives as unapproved drugs with opioid-like effects, while local jurisdictions are targeting specific formulations linked to adverse events. Dave breaks down how this represents a broader shift in how edge-case compounds are regulated, why supply volatility and underground markets can increase risk, and what this means for biohackers who experiment with gray-area tools. He also explains how evolving enforcement strategies could shape future access to peptides, nootropics, and other advanced compounds.
• Sources:
– Kansas City coverage: https://www.kshb.com/news/local-news/strong-high-weak-laws-7-oh-ban-kratom-regulation-moves-forward-in-kansas-city-missouri
– Florida policy coverage: https://www.wgcu.org/health/2026-02-04/kratom-advocates-tout-its-properties-but-legislators-want-strict-warnings-about-the-herbal-supplement
– Legal landscape analysis: https://www.lumalexlaw.com/2025/10/09/kratoms-legal-future-how-states-and-the-federal-government-are-responding/
– FDA background: https://www.fda.gov/news-events/public-health-focus/fda-and-kratom

All source links are provided for direct access to the original reporting and research.

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: Mic-628 circadian drug, jet lag recovery science, chronotherapy biohacking, late life depression dementia risk, Parkinson’s prodromal symptoms, ACTIVE trial dementia prevention, speed of processing training, brain aging coffee study, moderate caffeine longevity, kratom regulation 7-OH, supplement law biohacking, neurodegeneration early signals, cognitive performance training, circadian rhythm optimization, metabolic brain health, biohacking news

Thank you to our sponsors!
- Antarctica Trip | Join me in Antarctica from March 8–17, 2026. Visit https://www.insiderexpeditions.com/future and use code DAVE for $1,000 off.
- TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

Resources:
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 - Introduction
0:18 - Story #1: Circadian Drug for Jet Lag
2:00 - Story #2: Depression as Early Warning Sign
3:30 - Story #3: Brain Processing Speed Training
4:56 - Story #4: Coffee and Brain Health
6:24 - Story #5: Kratom Regulation
8:21 - Weekly Roundup
9:25 - Closing
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your phone, your lighting, and your WiFi can mess with your sleep and energy more than your diet, and this episode shows you the simplest fixes that actually move the needle.

-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR
-Grab a generous discount from BONCHARGE by using code ‘DAVE’ on your next purchase: https://boncharge.com/

Host Dave Asprey sits down with Andy Mant, Co-Founder and CEO of BON CHARGE, and Katie Mant, Co-Founder and Chief Visionary Officer, to unpack how modern light, WiFi, and nonstop screen exposure are quietly shaping your sleep, hormones, and energy. After facing their own struggles with fatigue and poor sleep, they built BON CHARGE around science-backed biohacking tools designed to improve sleep, recovery, and overall wellness.

They start with blue light at night and content overload, why light acts as biological information, and how simple changes like wearing blue light blocking glasses before bed can shift your circadian rhythm. The conversation moves into EMFs, native versus non-native frequencies, and what happened when they lived in an apartment flooded with WiFi and 5G. Dave shares his DEXA scan showing about 15% lower bone density where he used to carry his phone and explains why he now limits direct exposure.

You’ll also get a practical breakdown of red light therapy and PEMF, including the difference between visible red and near-infrared light, how dosing affects results, and how mat-based PEMF is used to support relaxation and recovery. This episode stays grounded: you do not have to give up technology, you just have to learn how to hack your environment so it works for your biology instead of against it.

You’ll Learn:
• Why blue light at night can disrupt sleep and circadian rhythm
• How light acts as information that shapes hormones and metabolism
• Practical EMF reduction strategies you can test immediately
• The difference between native and non-native EMFs
• Red light vs near-infrared light and how each is used
• Why dosing matters with red light therapy
• What Dave noticed on his DEXA scan after years of carrying a phone
• How PEMF mats aim to support relaxation and recovery

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Thank you to our sponsors!
• BEYOND Conference 2026 | Register now at https://beyondconference.com/ with code DAVE300 for $300 off
• KillSwitch | Order at https://www.switchsupplements.com/ and use code DAVE for 20% off
• Igniton | Head to https://igniton.com and use code DAVE for 15% off your first order
• LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: blue light sleep, red light therapy benefits, EMF health effects, 5G radiation health, WiFiradiation exposure, circadian rhythm sleep, PEMF therapy mat, pulsed electromagnetic field therapy, near infrared light therapy, biohacking sleep optimization, mitochondrial ATP production, airplane mode at night, low EMF devices, Dave Asprey biohacking, BON CHARGE red light

Resources:
• BONCHARGE Website. Use Code ‘Dave’ For A Discount: https://boncharge.com/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 — Introduction
1:23 — Blue Light and Content Consumption
2:31 — Light’s Impact on Health
4:18 — EMF Awareness and Mitigation
9:16 — Living in EMF Hotspots
13:43 — Native vs Non-Native EMFs
15:23 — PEMF Therapy Benefits
17:02 — EMF Protection Products
22:02 — Bone Density and Phone Placement
25:36 — Red Light Therapy Introduction
28:06 — Red Light Science and Wavelengths
31:00 — Red Light Dosing and Frequency
35:46 — Hair Growth and Red Light
40:15 — PEMF Technology Explained
46:39 — Closing and Resources
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you a clear framework for understanding peptides, research chemicals, and performance enhancement so you can think for yourself instead of outsourcing your biology

Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dylan Gemelli for a candid, unfiltered conversation about the underground world of biohacking, research chemicals, and human performance. Dylan is a long-time biohacker, educator, and researcher who came out of the bodybuilding world and spent more than a decade studying peptides, SARMs, nootropics, and gray-area compounds. He brings first-hand experience, deep research literacy, and a rare ability to explain what these compounds actually do, where the risks are, and why most doctors will never talk about them.

Together, they unpack what “research chemicals” really means, why peptides technically fall into that category, and how legality often has little to do with biological reality. They explore compounds like MK-677, S4, and other SARMs, how they interact with growth hormone, muscle, strength, and recovery, and why some of these tools can be more powerful than peptides when used with intention and restraint. Dave also shares his own experiences rebuilding his health using underground tools, why he refuses to ask for permission to take care of his body, and how performance enhancement fits into longevity, metabolism, and real-world function.

You’ll Learn:
• What research chemicals actually are and why peptides fall into that category
• How compounds like MK-677 stimulate growth hormone and affect muscle and recovery
• Why SARMs differ from steroids and where the real risks come from
• The difference between tobacco and nicotine and why low-dose nicotine can support brain optimization
• How performance enhancement fits into longevity, metabolism, and functional medicine thinking
• Why strength and neurological drive matter more than size alone
• How to think clearly about supplements, nootropics, and biohacking tools without fear or hype
• Why taking responsibility for your biology is not cheating

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Thank you to our sponsors!
• Antarctica Trip | Join me in Antarctica from March 8–17, 2026. Visit https://www.insiderexpeditions.com/future and use code DAVE for $1,000 off.
• AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.
• STEMREGEN | Go to https://stemregen.co/dave30 and use code DAVE30 for 30% off your next order.
• Our Place | Visit https://fromourplace.com/DAVE and use code DAVE for 10% off sitewide.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: biohacking research chemicals, peptide biohacking podcast, underground peptides, SARMs explained, MK-677 growth hormone, performance enhancing drugs science, human performance biohacking, longevity biohacking podcast, neuroplasticity optimization, brain optimization nootropics, mitochondrial optimization biohacking, metabolism and hormones, testosterone optimization science, nicotine brain benefits, modafinil cognitive performance, supplements biohacking debate, functional medicine biohacking, muscle vs strength science, anti-aging performance strategies, Dave Asprey biohacking, Dylan Gemelli biohacking, The Human Upgrade podcast, Smarter Not Harder biohacking

Resources:
• Learn More About Dylan’s Work And Content At: https://dylangemelli.com/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 - Introduction
1:28 - SARMs & Research Chemicals
7:43 - 29 Pounds of Muscle in 6 Weeks
10:20 - MK-677 & Growth Hormone
16:41 - Vegan Diet Disaster
18:30 - From Bodybuilding to Biohacking
21:31 - Diet Transformation & Metabolism
29:14 - Reversing Heart Plaque
33:50 - Exercise, Cardio & Longevity
44:16 - Testosterone, TRT & Kyzatrex
50:06 - Healthcare Freedom
53:23 - Medical Freedom
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your muscles play a far bigger role in aging than most people realize. As you get older, the energy factories inside your muscle cells begin to break down and stop getting replaced, leading to fatigue, weakness, and slower recovery even if you stay active.
This video explains how that decline happens, why it accelerates after midlife, and what actually restores cellular energy instead of just masking the symptoms.
By understanding how muscle health, energy production, and recovery are biologically connected, you can rebuild strength, improve endurance, and slow the aging process from the inside out.

Chapters
0:00 - Intro: The Youth Switch
0:53 - Why Muscles Are Your Fountain of Youth
2:26 - Mitophagy: Your Body's Cleaning System
4:01 - The Secret Compound: Urolithin A
6:30 - The Solution: MitoPure
8:34 - The Complete System
9:56 - Closing Thoughts

Thank you to our sponsors!
MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.
Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.

Resources:
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com

Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast:
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