Immune

Jenna Guthmiller talks about how she became interested in immunology and her exciting research on how different responses to vaccines and infection shape future responses to infection. 

Host: Cindy Leifer
Guest: Jenna Guthmiller
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Broadly neutralizing flu antibodies (Nature, 2022)
First exposure antibodies to H1N1 flu (Sci Transl Med, 2021)
Long lasting B cells to chimeric flu vaccine (Immunity, 2025)
Vaccine strategies to target HA anchor epitope (Nat Comm, 2025)
Pre-existing immunity shapes flu response (Sci Trans Med, 2020)
From Immune 35: SARS-CoV-2 infection severity linked to anti-spike (mBio, 2021)
Guthmiller lab
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Immune discusses a snippet on how EBV infection alters the immunopeptidome and promotes multiple sclerosis, and a paper on head and neck cancers harboring bacteria that create an immunosuppressive environment and promote immunotherapy resistance.


Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker
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EBV, Golli-MBP presentation and multiple sclerosis (Cell, 2026)
Intratumoral bacteria promote resistance to cancer immunotherapy (Nat Cancer, 2026)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Gabriel Nunez discusses the discovery of NOD-like receptors, NOD1 and NOD2, in inflammatory bowel disease and how travel and taking a moment to enjoy local culture and art influences his creativity.
Host: Cindy Leifer
Guest: Gabriel Nuñez

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HLA and antigen presentation (Hum Immunol, 1987)
Bcl2, cell death, and B cells (Nature, 1991)
Discovery of NOD1 (J Biol Chem, 1999)
Discovery of NOD2 (J Biol Chem, 2001)
Mutation in NOD2 and connection to Crohn's disease (Nature, 2001)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective.

Host: Cindy Leifer
Guest: Martha Alexander-Miller
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Flu HA nanoparticle vaccine (Nat Comm, 2025)
Sex-dependent adjuvant activity in newborns (Vaccines, 2024)
Flu vaccine with R848 adjuvant (Vaccines, 2023)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

The Immune team talks about two papers on the effect of sleep and environment on seasonal allergies. 
Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker
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Links for this episode
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Sleep is needed for condition dependent allergic responses (PNAS, 2020)
Original paper on allergy to artificial rose (Am. J. Med. Sci. 181, 45–56 (1886))
One of multiple personalities allergic (Am J Clin Hypn, 1983)
Environmentally driven immune imprinting protects against allergy (Nature, 2026)
News and Views on immune imprinting paper (Nature, 2026)
Immune 90 discussion of "dirty mice"
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.