Daily Value

• The Mitochondrial “Vitamin” from Interstellar Dust

  There’s a molecule that’s been tentatively identified in the same interstellar material that forms stars and planets, yet it also shapes growth, metabolism, and cognition here on Earth. In several mammalian species,Its absence causes deficiency and it's repletion, resolution; and no, it’s not a vitamin, but should it be?Its chemistry is analogous to the combination of vitamin B2, vitamin B6 vitamin C, and its role in evolution may trace back to the very beginning of biology.00:00 – From Interstellar Dust to Human Biology01:06 – Discovery: A New Redox Co-Factor01:44 – Biological Role: Deficiency, Growth, and Evolution02:41 – Mechanisms: NAD⁺ Regeneration and Mitochondrial Signaling03:11 – Human Evidence: Cognitive and Metabolic Effects04:41 – Chemistry & Safety: Potency and Tolerability06:55 – Conclusionhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8533503/

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• Boost Your Serotonin Naturally: The Nutrition Secret

  Serotonin is often described as the “happiness molecule,” but its biology tells a larger story. Nearly every step in serotonin’s synthesis and signaling, from the transport of dietary tryptophan to the enzymes that convert it, is influenced by nutrition.This episode examines how macronutrients, micronutrients, and gut-derived metabolites shape serotonin availability across the brain and body. Protein and carbohydrate balance determine how much tryptophan enters the brain. Specific vitamins and minerals serve as essential cofactors in its production and turnover, and so on…Understanding serotonin through this nutritional lens reframes it not as a simple neurotransmitter, but as a metabolic signal connecting diet, metabolism, and mood regulation.00:00 Introduction to Serotonin01:07 Evolutionary Role of Serotonin02:08 Nutritional Influence on Serotonin Synthesis02:55 Enzymatic Pathways of Serotonin Production04:21 Macronutrients: Impact on Serotonin06:32 Vitamins and Minerals: Impact on Serotonin09:27 Plant Compounds and Gut Microbiome: Impact on Serotonin10:24 Serotonin as a Biochemical Bridgehttps://pubmed.ncbi.nlm.nih.gov/40998119/

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• Discovered: an amino acid that helps the gut heal itself

  Every few days, your gut rebuilds itself completely - cell by cell, guided by signals we still don’t fully understand. For years, scientists have known that diet can influence this process, but the exact messenger between what we eat and how the gut heals has remained a mystery.In this episode, we look at new research from MIT that uncovers a surprising link between diet, the immune system, and regeneration in the intestine. It’s a story about how a single nutrient can activate immune cells to release molecules that tell the gut when it’s time to repair.It challenges the way we think about food, not just as fuel, but as information. Because the gut isn’t just digesting what we eat… it’s listening.00:00 Introduction to Gut Regeneration00:56 The Role of Amino Acids in Gut Health02:07 ???: A Key Player in Gut Regeneration02:35 MIT's Groundbreaking Research 03:49 The Immune System's Role in Gut Regeneration05:51 Dietary Sources and Implications 07:07 Conclusion: The Gut's Adaptive NaturePMID: 41034585

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• Creatine’s Role in Mitochondria is Bigger Than You Thought

  Creatine’s story has been far too small for its biology. Most people still see it as a supplement for strength or cognitive performance, but its most important work happens inside the mitochondria.In this episode, we explore a side of creatine few people talk about: how it may function as mitochondrial medicine. We’ll break down 3 distinct ways creatine acts in and supports the mitochondria; roles that could reshape how we think about energy, resilience, and cellular health.  And beyond that, how creatine may be one of the few molecules that can both diagnose and treat mitochondrial dysfunction. 00:00 Understanding Mitochondrial Dysfunction00:43 Introduction to Creatine's Role01:16 Mitochondrial Dysfunction Explained01:56 Creatine as a Theranostic Agent02:57 Mechanisms of Creatine in Mitochondria04:09 Therapeutic Roles of Creatine05:22 Redox Control and Antioxidant Properties06:27 Conclusion: The Unique Power of Creatine PMID: 40948982

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• Polyphenols Are Doing Something No One Expected

  In this episode of The Daily Value, we look at new research suggesting that polyphenols might be doing something we never expected — not just acting as antioxidants, but organizing themselves into microscopic structures that can stabilize the very proteins that keep our cells alive. It’s a discovery that could reshape how we think about plant compounds and resilience at the molecular level. We explore how this structural behavior gives new meaning to the idea that diversity matters in our diet — and why the age-old advice to “eat the color spectrum” may be more scientifically accurate than anyone realized.00:00 – The Flavonoid Paradox: Quantity vs. Diversity01:12 – What Are Polyphenols Really Doing in the Body?02:16 – Diversity as a Predictor of Longevity and Disease Risk03:17 – Beyond Antioxidants: A New Molecular Hypothesis03:58 – Self-Assembling Flavonoids and Protein Stabilization05:45 – Mechanistic Insight: How Molecular Networks Support Cellular Resilience09:45 –The Science Behind “Eat the Color Spectrum”

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