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Beyond the Prescription

Lucy McBride MD
Beyond the Prescription
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  • A Conversation with Dr. Mary Claire Haver about menopause, perimenopause & HRT 🔥
    Episode SummaryIn this conversation, Dr. Lucy McBride hosts Dr. Mary Claire Haver, the renowned board-certified OBGYN from Galveston, Texas. Dr. Haver, author of the bestselling book The New Menopause, discusses the current menopause moment, the complexities of hormone replacement therapy, and why women have been deprived of essential information about their hormonal health for decades. The conversation covers everything from the misinterpretation of the Women's Health Initiative study to practical prescribing guidelines for estrogen, progesterone, and testosterone. Both doctors emphasize that menopause care requires a nuanced, individualized approach that treats the patient, not just the symptoms or lab values.Key ConceptsThe Current "Menopause Moment"* Social media as catalyst: Dr. Haver explains that social media has become a powerful platform where women share their menopause experiences, creating unprecedented awareness and demand for better care* Generational shift: Gen X women are refusing to "quietly suffer" through symptoms like vaginal atrophy, bone deterioration, and cognitive decline* Health span focus: Patients are increasingly concerned with quality of life and preventing the trajectory of decline they witnessed in their mothers and grandmothers* Caregiver burden awareness: Women are motivated by not wanting to burden their children with preventable chronic illnesses and disabilitiesThe Women's Health Initiative Legacy and Medical Education Gaps* Flawed interpretation: The 2002 Women's Health Initiative study wasn't inherently flawed, but its interpretation and media coverage created decades of fear around hormone replacement therapy* Medical school inadequacy: Both doctors received minimal menopause education—Dr. Haver recalls just one hour in medical school with outdated information* "Bikini medicine" concept: Dr. Haver describes OB-GYN as focusing primarily on "breast, uterus, vagina" rather than comprehensive women's health* Guideline conflicts: Current conflicting guidelines between ACOG and the North American Menopause Society create confusion for practitioners* Systemic healthcare bias: The medical system struggles to address symptoms that can't be measured in blood tests or imagingHormone Replacement Therapy: Estrogen Formulations and Prescribing* Oral vs. transdermal delivery: Oral estrogen carries a small increased risk of blood clots (7 in 10,000) due to first-pass liver metabolism, while transdermal forms (patches, gels, sprays) avoid this risk entirely* Cardiovascular benefits: Oral estrogen may offer slightly better cardiovascular protection and LDL reduction due to liver metabolism* Bone protection thresholds: Different estrogen levels provide different benefits—some stop bone degradation while higher levels can actually build bone* Individual absorption variability: Patients absorb hormones differently, requiring personalized dosing and monitoring* Cost considerations: Generic patches are often the most affordable option, while newer formulations like gels and rings can be expensiveProgesterone: Beyond Endometrial Protection* Mandatory for uterus owners: Women with a uterus must take progesterone with estrogen to prevent endometrial overgrowth and cancer risk* Sleep and anxiety benefits: Progesterone converts to allopregnenolone, which binds to GABA receptors and provides sedative effects* Multiple delivery options: IUDs can provide local progesterone for endometrial protection while oral progesterone can be added for sleep benefits* Individual tolerance: Some women experience paradoxical stimulation or next-day grogginess from progesterone* Newer options: Duavee combines conjugated estrogen with bazedoxifene, a SERM that blocks estrogen receptors in breast and uterine tissueTestosterone: The Overlooked Hormone* Age-related decline: Testosterone levels begin declining at age 30 in women, reaching about 50% of peak levels by age 50* FDA approval gap: Despite multiple medical societies supporting testosterone for low libido treatment, the FDA has not approved any testosterone products specifically for women* Evidence for libido: Strong evidence supports testosterone use for hypoactive sexual desire disorder in women* Potential broader benefits: While not definitively proven, observational data suggests women with higher natural testosterone levels have better bone density, muscle strength, and lower frailty scores* Dosing challenges: Women must use compounded or modified men's formulations due to lack of FDA-approved optionsThe Zone of Chaos: Understanding Perimenopause* Clinical diagnosis: Perimenopause is diagnosed based on symptoms and patient history, not blood tests, due to wildly fluctuating hormone levels* 7-10 year process: The transition from regular cycles to menopause typically takes 7-10 years as egg supply dwindles* Unpredictable patterns: Unlike the predictable monthly cycle of reproductive years, perimenopause involves erratic hormone fluctuations* Multiple system effects: Estrogen affects every body system—brain, bones, heart, vagina, mood—making perimenopause symptoms diverse and complex* Treatment complexity: Managing perimenopause often requires different approaches than treating postmenopausal women, including considerations about contraception needsThe UpshotThis conversation illuminates why menopause care represents one of medicine's most significant gaps in women's health. The combination of inadequate medical education, misinterpreted research, conflicting guidelines, and time-constrained healthcare visits has left millions of women without access to evidence-based treatment. Dr. Haver's work, along with other menopause advocates, is helping to change this narrative by emphasizing that menopause is not just about hot flashes—it's about optimizing health span and preventing the cascade of age-related diseases that disproportionately affect women after menopause.The key takeaway is that menopause care requires a toolkit approach where hormone replacement therapy is one important tool among many, including nutrition, exercise, stress management, and sleep optimization. For women who missed the opportunity for hormone therapy during their menopause transition, it's never too late to focus on building better health through lifestyle interventions and appropriate medical care. The goal isn't just living longer—it's about maintaining vitality, independence, and quality of life throughout the aging process.Most importantly, this conversation underscores the need for women to become educated advocates for their own health, to seek out menopause-knowledgeable providers, and to make decisions based on current evidence rather than outdated fears. As Dr. Haver emphasizes, women armed with good information make great decisions for themselves. Get full access to Are You Okay? at lucymcbride.substack.com/subscribe
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  • Sexual health is health: a conversation with urologist & sex med expert Dr. Rachel Rubin about menopause, HRT, & genitourinary health
    Episode SummaryIn this comprehensive discussion, Dr. Lucy McBride interviews urologist and sexual medicine expert Dr. Rachel Rubin about the critical but often overlooked aspects of sexual health, hormone replacement therapy, and genitourinary syndrome of menopause. Dr. Rubin shares her holistic approach to patient care, explaining why sexual health should be treated like any other organ system and providing evidence-based solutions for common issues affecting both women and men. The conversation covers the biology of hormones, the safety and efficacy of various treatments, and the urgent need for better education among healthcare providers about these vital health topics.Key Topics DiscussedThe Importance of Comprehensive Sexual Health Care* Drs. Rubin and McBride emphasize treating sexual health as a vital sign, just like checking blood pressure or cholesterol* They advocate for creating nonjudgmental spaces where patients feel comfortable discussing intimate concerns* The conversation highlights how taking time with patients and asking the right questions can transform care* Dr. Rubin notes that sexual health problems are more common than diabetes, heart disease, or osteoporosisThe Bio-psycho-social Approach to Low Libido* Low libido affects approximately 40% of women, but only 10% are bothered enough to seek treatment* Treatment requires addressing both biological factors (hormones, medications) and psychosocial factors (therapy, education, relationship dynamics)* Antidepressants, while often necessary, can significantly impact sexual function for both men and women* The approach must be individualized, meeting patients where they are and addressing their specific goalsTestosterone: The Forgotten Hormone for Women* Ovaries produce significantly more testosterone than estrogen—about 10 times more when measured in equivalent units* Testosterone decline begins in a woman's 30s, contributing to low libido, urinary symptoms, and loss of muscle mass* Despite extensive safety data, no FDA-approved testosterone exists for women due to regulatory barriers and moved goalposts* Transdermal testosterone gel can be life-changing for women and for men, often taking 3-6 months to show full effectsHormone Replacement Therapy: Safety and Efficacy* Transdermal estrogen (patches, gels, rings) is superior to oral estrogen for sexual function due to lower impact on sex hormone binding globulin* The Women's Health Initiative actually showed estrogen decreased breast cancer risk—it was never the problem* For the majority of women, the benefits of HRT outweigh the risks of HRT—if, that is, HRT is started within the first 10 years after a woman’s last menstrual period* The combination of estrogen, progesterone, and testosterone often provides optimal results for menopausal symptomsVaginal Estrogen: A Life-Saving Treatment* Low-dose vaginal estrogen reduces UTI risk by more than 50% and prevents hospitalizations and sepsis* The treatment costs only $13 per tube and lasts 2-3 months, potentially saving Medicare $6-22 billion annually* Proper application requires using a full gram of cream rubbed into vaginal walls, not just a pea-sized amount* The American Urological Association recently released guidelines confirming vaginal estrogen's safety and efficacyBuilding a Healthcare "Pit Crew" for Sexual Health* Patients may need multiple specialists: sex therapists, menopause doctors, physical therapists, and sexual medicine experts* Dr. Rubin focuses on four key areas: libido, arousal, orgasm, and pain* The field of sexual medicine is rapidly evolving with new research, treatments, and educational opportunities* Healthcare providers need continuing education to stay current with evidence-based sexual health treatmentsKey TakeawaysDr. Rubin's advocacy work has led to significant policy changes, including new guidelines from the American Urological Association that explicitly state vaginal hormones are safe and effective. Her mission extends beyond individual patient care to systemic change through research, education, and mentorship. The conversation underscores that sexual health problems are treatable medical conditions, not inevitable parts of aging, and that patients deserve knowledgeable, compassionate care that addresses all aspects of their wellbeing.The discussion emphasizes that while the field of sexual medicine has made tremendous advances, there's still significant work to be done in training healthcare providers and changing cultural attitudes about sexual health. Dr. Rubin's approach demonstrates that with proper education and tools, any clinician can effectively address these common but often overlooked health concerns.You can find Dr. Rubin at www.rachelrubinmd.com! Get full access to Are You Okay? at lucymcbride.substack.com/subscribe
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  • Gut Health: Practical Solutions for Common GI Issues
    Episode SummaryIn this episode, Dr. Lucy McBride addresses the most common gastrointestinal complaints she encounters in her primary care practice. She emphasizes that most GI issues aren't mysterious and often have simple solutions when approached systematically. The conversation covers five main digestive problems—IBS, GERD, bloating and gas, constipation, and colon cancer prevention—while highlighting the important connection between emotional health and digestive symptoms. Dr. McBride advocates for a holistic approach that considers everything patients consume, their stress levels, and lifestyle factors, rather than relying solely on lab tests for common complaints.Key ConceptsIRRITABLE BOWEL SYNDROME (IBS): IT'S REAL AND IT'S MANAGEABLE* IBS is a functional disorder where the colon becomes spastic and irritable, causing alternating diarrhea and constipation, bloating, gas, and abdominal discomfort - it's not dangerous but can be very distressing* Common trigger foods include alcohol, caffeine, sugar, dairy, and gluten, plus FODMAP foods (short-chain fermentable carbohydrates like beans and certain fruits and vegetables)* The gut is literally the "home of many of our emotions" - stress, anxiety, and emotional distress often show up as digestive symptoms, which is why travel causes constipation and anxiety can trigger diarrhea* Treatment involves systematically identifying your personal trigger foods, managing stress through exercise or therapy, and addressing underlying emotional health rather than just taking testsGERD: WAY MORE THAN JUST HEARTBURN* GERD happens when stomach acid travels upward into the esophagus instead of downward - it can cause chronic cough, sore throat, sinus symptoms, and morning nausea, not just chest burning* Common culprits include NSAIDs (Advil, ibuprofen), acidic foods and drinks (wine, coffee, vinegar, tomatoes, citrus), certain medications, and emotional stress that increases acid production* Simple fixes include reducing acidic foods, elevating the head of your bed with wedge pillows, eating earlier in the evening, and reviewing your medication list with your doctor* Dr. McBride recommends the book "Dropping Acid" as a practical guide to reducing dietary triggersBloating and Gas: The Usual Suspects* Primary triggers include sugar-free gum and sweeteners, NSAIDs, too much fiber (yes, you can have too much of a good thing), eating too quickly, and not moving your body enough* Many gas-producing foods are FODMAPs, but don't eliminate everything on the list at once - pin it to your refrigerator and notice correlations between what you eat and your symptoms* Your gut needs movement to function properly - if your body isn't moving, your gut sits there "too quiet" and needs motion to get things going* Focus on gradual identification of your personal triggers rather than wholesale dietary restrictions that leave you feeling restrictedCONSTIPATION: FIBER IS YOUR FRIEND (PLUS A FEW OTHER HELPERS)* The most common cause is simply not getting enough dietary fiber from fruits, vegetables, leafy greens, and whole grains - "fiber, fiber, fiber, fiber, fiber"* GLP-1 medications like Ozempic, Mounjaro, and Wegovy commonly cause constipation as a known side effect* Dr. McBride's go-to recommendations include Colace (docusate) as a safe stool softener, magnesium supplements (400-500mg) for muscle relaxation, and Swiss Kriss - however hers is not a substitute for advice from your personal physician * Don't forget the basics: regular exercise, adequate hydration, and stress management all support healthy bowel motilityCOLON CANCER SCREENING: THE GOALPOST HAS MOVED* Screening colonoscopy is now recommended starting at age 45 (down from 50), or earlier if you have a family history of colon cancer, especially in first-degree relatives* Colonoscopy is both diagnostic and therapeutic - it can detect cancers and polyps while removing polyps during the procedure to prevent future cancer* Cologuard stool tests are "pretty amazing" technology but aren't as sensitive as colonoscopy and can't remove polyps if found* Red flags requiring immediate medical attention include rectal bleeding, persistent changes in bowel habits lasting weeks or months, unintentional weight loss, and severe abdominal painTHE GUT-MIND CONNECTION: YOUR EMOTIONS LIVE IN YOUR STOMACH* Stress, anxiety, and emotional distress commonly express themselves through digestive symptoms - some patients use their gut as a "check engine light" for when they need better self-care* Address mental health through therapy, exercise, journaling, and stress management alongside dietary changes for the most effective treatmentUpshotCommon digestive complaints often have straightforward solutions that don't require extensive testing or complex interventions. The key lies in taking a systematic inventory of everything consumed, recognizing the profound connection between emotional health and gut function, and addressing lifestyle factors like movement and hydration and behaviors around eating. She advocates for patients to become detective-like in tracking their symptoms and triggers, while also ensuring appropriate medical evaluation to rule out serious conditions. Get full access to Are You Okay? at lucymcbride.substack.com/subscribe
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  • Navigating COVID in 2025: A Conversation with Adam Cifu, MD
    Episode SummaryIn this live (unedited!) discussion, Dr. Lucy McBride sits down with Adam Cifu, MD to examine the evolving COVID landscape in 2025. This conversation explores recent FDA and CDC guidance, the challenges of medical decision-making under uncertainty, and the broader implications for how Americans navigate health information in an era of politicized science. Both physicians emphasize the importance of humility, nuanced thinking, and the irreplaceable value of the patient-doctor relationship in making complex health decisions.Key ConceptsThe New COVID Vaccine Landscape* The FDA's recent recommendations target specific populations: those over 65 and those under 65 with underlying conditions should receive COVID vaccines* The guidance represents a shift toward more targeted, evidence-based recommendations rather than universal vaccination* Initial proposals to remove COVID vaccines from pediatric schedules and discourage use in pregnant women were later moderated by CDC intervention* Both physicians noted the transparency of the new approach, which clearly states what studies would be needed to expand recommendationsRisk Assessment and Trade-offs in Medicine* Every health decision involves trade-offs; there are risks of taking action and risks of not taking action* COVID vaccines are safe but, like all medical interventions, carry small risks that must be weighed against benefits* The benefit-to-risk ratio varies significantly based on individual factors like age, health status, and previous COVID exposureThe Limits of Scientific Certainty* Current COVID vaccine recommendations operate in a "data-free zone" compared to earlier pandemic guidance* Unlike established treatments where physicians know precise benefit numbers, COVID vaccine efficacy in 2025 populations remains unclear* The absence of updated clinical trials in highly vaccinated/previously infected populations creates uncertainty for practitioners* Both physicians acknowledged frequently having to say "I don't know" when patients ask about COVID interventionsLong COVID: Perspective and Reality* Post-viral syndromes have existed throughout medical history; COVID's uniqueness lies in the scale of infections, not necessarily the phenomenon itself* With widespread immunity from vaccination and previous infections, new cases of debilitating long COVID appear to be rare* Fear of long COVID may now cause more harm than actual long COVID infections* The term "long COVID" has become a catch-all for various post-illness symptoms that may have different underlying causesMedical Misinformation and Trust* The current era represents a "snake oil salesman renaissance" where certainty sells better than nuanced advice* Algorithms reward confident messengers over those who acknowledge uncertainty* The most valuable medical advice for healthy people is often "boring basics": exercise, sleep, nutrition, avoiding smoking* Longevity and optimization influencers often oversell marginal interventions while ignoring fundamental health practicesThe Irreplaceable Value of Primary Care* Individual medical decisions require understanding the whole person, not just population-level data* The fragmentation of healthcare means that specialists don’t always see the whole person—they can’t—and too many Americans lack a medical home* Primary care relationships built over time allow for the most important conversations about values, goals, and everyday health decisions * Both physicians advocate for expanding access to primary care as the foundation of good healthcareKey TakeawayAs the COVID pandemic transitions to an endemic phase, the conversation highlights medicine's fundamental challenge: making decisions under uncertainty while maintaining trust with patients. Dr. McBride and Dr. Cifu argue that the path forward requires embracing humility about what we don't know, focusing on proven fundamentals of health, and preserving the sacred relationship between patients and their primary care providers. Rather than seeking certainty in an uncertain world, Americans need physicians who can acknowledge limitations while providing thoughtful, individualized guidance based on the best available evidence and understanding of each person's unique circumstances and values. Get full access to Are You Okay? at lucymcbride.substack.com/subscribe
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  • How to manage stress & improve your mental health: a conversation with best selling author and physician Dr. Aditi Nerurkar
    Join Dr. McBride every Friday at 3 pm ET for her live Q&As in the app!Episode SummaryDr. Lucy McBride speaks with physician and bestselling author Dr. Aditi Nerurkar about managing stress and vulnerability in times of uncertainty. Dr. Nerurkar shares her personal journey with stress-related health issues and discusses practical strategies from her book "The Five Resets" to help people rewire their brains for resilience. Both physicians emphasize that mental health is universal, not optional, and offer actionable advice for managing stress amidst life's challenges.Understanding Mental Health as Universal* Dr. Nerurkar emphasizes that mental health is a universal phenomenon that everyone has, just like cardiovascular health* Many physical symptoms (migraines, jaw tension, back pain, stomach issues) can be manifestations of stress* 60-80% of all primary care visits have a stress-related component, yet only 3% of doctors counsel for stress* Both doctors share personal experiences of physical symptoms caused by stress during their medical training* Mental and physical health are inseparable; there's no partition between the brain and the rest of the bodyThe Five Resets Framework* Reset 1: Get clear on what matters most using the MOST goal-setting framework (Motivating, Objective, Small enough to virtually guarantee success, Timely)* Reset 2: Get quiet and find calm in a noisy world* Reset 3: Sync your brain to your body* Reset 4: Bring your best self forward* Reset 5: Come up for air* Creating a "backwards plan" to visualize steps from current state to desired goal* Each reset includes 3-4 science-backed strategies for implementationPractical Stress Management Techniques* "Stop, Breathe, Be" - a 3-second brain reset to get out of "what if" thinking and back to the present moment* 4-7-8 breathing technique (inhale for 4, hold for 7, exhale for 8) to activate the parasympathetic nervous system* Digital boundaries: keeping phones off nightstands, switching to grayscale mode, using alarm clocks instead of phones* Combating "revenge bedtime procrastination" - the tendency to delay sleep despite knowing better* Using accountability partners for both digital boundaries and exercise commitmentsThe Science of Stress* Understanding amygdala activation (fight-or-flight) versus prefrontal cortex functioning (planning, organization)* The delayed stress response: keeping it together until you feel psychologically safe, then experiencing symptoms* How scrolling impacts brain chemistry and primes the brain for stress* The relationship between anxiety and insomnia creates a self-reinforcing cycle* Stress from the pandemic and current events creates a collective delayed stress responseThe Importance of Social Connection* Research shows both deep relationships and casual interactions ("weak ties") benefit mental health* Weak ties (brief interactions with strangers or acquaintances) build community without requiring emotional depth* Finding community through shared activities like exercise classes* Digital life has made isolation easier and social connection more challenging* An accountability partner can help bridge the gap between intention and executionThe Gap Between Knowledge and Action* Most people know what they should do for better mental health, but struggle with implementation* Self-compassion is essential during the process of forming new habits* It's normal to fall off track and get back up during habit formation* Asking for help is a strength, not a weakness* Recognizing we're living through a "perfect storm" of stressors that the human brain wasn't designed to handleUpshotBoth Dr. McBride and Dr. Nerurkar underscore that improving mental health isn't about a knowledge deficit but about closing the gap between intention and action. Through practical strategies like the MOST framework, breathing techniques, and intentional social connections, everyone can build resilience even amid ongoing challenges. As Dr. Nerurkar quotes Pema Chödrön: "You are the sky, everything else is just the weather" – a powerful reminder that while we can't control external circumstances, we can develop tools to navigate them more effectively. Get full access to Are You Okay? at lucymcbride.substack.com/subscribe
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Each week, Dr. Lucy McBride talks with her guests like she does her patients — pulling the curtain back on what it means to be healthy, connecting the dots between mental and physical health. To Dr. McBride, health is about more than the absence of disease. Health is a process, not an outcome. It's about having awareness of our medical facts, acceptance of the things we cannot control, and agency over what we can change. To learn more about Dr. McBride, visit: https://www.lucymcbride.substack.com/about To sign up for her weekly newsletter, visit www.lucymcbride.substack.com/welcome lucymcbride.substack.com
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