Health & Veritas

• Sudhakar Nuti: Bringing Healthcare to the Unhoused

  Howie and Harlan are joined by Sudhakar Nuti to discuss his work improving healthcare for homeless New Yorkers, as a street-medicine doctor and a population-health leader at NYC Health + Hospitals. Harlan reports on a proposed law that would cut off funding for U.S. scientists who collaborate with colleagues in China; Howie provides updates on the measles outbreak and a leaked FDA memo claiming that COVID-19 vaccines have killed 10 children. Show notes: Science Across Borders Subtitle C—SAFE Research Act "U.S. Congress considers sweeping ban on Chinese collaborations" Sudhakar Nuti NYC Health + Hospitals Street Medicine Institute "Health Care beyond Clinic Walls—Sustaining and Scaling Up Street Medicine" NYC Health + Hospitals: Street Health Outreach & Wellness Mobile Units "Graduate and professional students tackle food insecurity" California Depart of Public Health: Xylazine Measles CDC: Measles Cases and Outbreaks "Tracking U.S. Measles Outbreaks" World Health Organization: Weekly Epidemiological Record, 2025, vol. 100, no. 48 "Winning against measles: five charts that tell a remarkable 24-year story" "Measles deaths down 88% since 2000, but cases surge" FDA Leak "Experts say top FDA official's claim that Covid vaccines caused kids' deaths requires more evidence" "FDA's Prasad tells staffers agency plans to get tougher on vaccine regulation, blames child deaths on COVID shots" "Thoughts on Vinay Prasad's Leaked Email" "Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021" "Fulminant Myocarditis and Cardiogenic Shock Following COVID-19 Infection Versus COVID-19 Vaccination: A Systematic Literature Review" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.  

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• Peter Hotez: Mapping the Anti-Science Machine

  Howie and Harlan are joined by Peter Hotez, a vaccine expert and an outspoken opponent of health misinformation, to discuss vaccine skepticism and the forces—from wellness influencers to HHS secretary Robert F. Kennedy Jr.—that amplify it. Harlan reports on research reinforcing the link between social media and mental illness; Howie highlights two potential areas of common ground with the administration's health policy.  Show notes: Social Media and Mental Health "Social Media Detox and Youth Mental Health" "Study Finds Mental Health Benefit to One-Week Social Media Break" Peter Hotez Peter Hotez: Science Under Siege: How to Fight the Five Most Powerful Forces That Threaten Our World Peter Hotez: Vaccines Did Not Cause Rachel's Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad "Scientist pressured by Musk and Rogan to debate RFK Jr over anti-vaccine misinformation says he won't be part of 'Jerry Springer' show" Peter Hotez on X "Kennedy Says He Told C.D.C. to Change Website's Language on Autism and Vaccines" "Wakefield's article linking MMR vaccine and autism was fraudulent" "Four vaccine myths and where they came from" "Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism" "Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure" "Data investigation: Childhood vaccination rates are backsliding across the U.S." "South Carolina's Measles Outbreak Shows Chilling Effect of Vaccine Misinformation" "How a measles outbreak overwhelmed a small West Texas town" "How polio came back to New York for the first time in decades, silently spread and left a patient paralyzed" "Third infant in Kentucky dies of whooping cough as national cases stay high for second year in a row" "Kennedy minimizes measles outbreak in wake of Texas death" "RFK Jr. claims 'leaky' measles vaccine wanes over time. Scientists say he's wrong." "RFK Jr. claims measles can be treated with vitamin A, linked to poor diet. Here's what science says" "The Surprise Ending to the Trump-Mamdani Buddy Movie Has Heads Spinning" "Operation Warp Speed was one of Trump's biggest achievements. Then came RFK Jr. and vaccine skeptics" Health & Veritas Episode 196: The Cost Curve, Flu, and Other News "Weaponized Health Communication: Twitter Bots and Russian Trolls Amplify the Vaccine Debate" ACA Subsidies "Trump was going to roll out a health care plan. Then Republicans weighed in." "Trump Is Considering a Push to Extend Obamacare Subsidies" Site-Neutral Payment "The Trump Administration Moves Forward with Medicare Site-Neutral Payment Reform" "Five Things to Know About Medicare Site-Neutral Payment Reforms" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

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• The Cost Curve, Flu, and Other News

  Howie and Harlan discuss the outlook for U.S. healthcare spending over the next five years, the state of seasonal and avian flu, and an expensive AI-based cardiac test.  Show notes: Life expectancy and expenditures "How does U.S. life expectancy compare to other countries?" ACOs and cost savings "After Fifteen Years, is Value-Based Care Succeeding?" Health & Veritas Episode 115: Farzad Mostashari: Aligning Incentives to Fix Primary Care World Prematurity Day WHO: World Prematurity Day 2025 WHO: World Prematurity Day Key Messages WHO: Preterm birth AI concerns "'It keeps me awake at night': machine-learning pioneer on AI's threat to humanity" "Why neural net pioneer Geoffrey Hinton is sounding the alarm on AI" "AI pioneer: 'The dangers of abuse are very real'" "'Malicious use is already happening': machine-learning pioneer on making AI safer" "Fathers of the Deep Learning Revolution Receive ACM A.M. Turing Award" "Deep learning" Bird flu "First U.S. case of human bird flu in 9 months confirmed in Washington state" Cleveland Clinic: Bird Flu (Avian Influenza) "Flu in numbers: NHS faces one of worst winters ever, officials warn, amid concern over mutated strain" "New flu virus mutation could see 'worst season in a decade'" "Australia posts record-breaking flu numbers as vaccination rates stall"  FDA: Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season Cardiology and AI "Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group" "Medicare will pay more than $1,000 for AI to analyze a heart scan. Is that too much?" Free speech and drug promotion "High-Engagement Social Media Posts Related to Prescription Drug Promotion for 3 Major Drug Classes" Health & Veritas Episode 195: Jerry Avorn: Countering the Drug Marketing Machine Medicare premiums "Medicare premiums to jump 10% heading into 2026" "Social Security Announces 2.8 Percent Benefit Increase for 2026" Centers for Medicare and Medicaid: 2026 Medicare Parts A & B Premiums and Deductibles In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

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• Jerry Avorn: Countering the Drug Marketing Machine

  Howie and Harlan are joined by Harvard internist Jerry Avorn to discuss his research on the pharmaceutical industry and his work promoting evidence-based prescribing. Harlan highlights new results from the American Heart Association meeting, including a one-time CRISPR-based therapy for high cholesterol; Howie reports on an outbreak of infant botulism. Show notes: Research from the American Heart Association Meeting "Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3" "First-in-human trial of CRISPR gene-editing therapy safely lowered cholesterol, triglycerides" "Cardiac Allograft Vasculopathy Inhibition with Alirocumab: The CAVIAR Trial" "PCSK9 medication plus statin may help lower cholesterol after heart transplant" "Investigational daily pill lowered bad cholesterol as much as injectables" Jerry Avorn Science Direct: Academic Detailing Jerry Avorn: "Principles of Educational Outreach ('Academic Detailing') to Improve Clinical Decision Making" Alosa Health FDA: Accelerated Approval Jerry Avorn: Rethinking Medications: Truth, Power, and the Drugs You Take FDA: Direct-to-Consumer (DTC) Advertisements H.R.5952 - Prescription Drug User Fee Act of 1992 FDA: FY 2025 FDA Budget Summary Centers for Medicare & Medicaid Services: Open Payments  H.R.3590 - Patient Protection and Affordable Care Act "Aducanumab Discontinued as an Alzheimer's Treatment" FDA: ELEVIDYS Brigham and Women's Hospital & Harvard Medical School: Division of Pharmacoepidemiology and Pharmacoeconomics Amazon.com: Featured comments on Rethinking Medications Infant Botulism California Department of Public Health: "Outbreak of Infant Botulism Linked to ByHeart Infant Formula" California Department of Public Health: Infant Botulism Treatment and Prevention Program CDC: "Infant Botulism Outbreak Linked to Infant Formula, November 2025" "ByHeart recalls all baby formula sold nationwide as infant botulism outbreak grows" California Department of Public Health: What is BabyBIG? California Department of Public Health: Postponement of BabyBIG Fee Increase California Department Of Public Health: Invoice and Purchase Agreement for BabyBIG In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.  

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• Ali Rahimi: A Cardiologist in Your Pocket

  Howie and Harlan are joined by cardiologist Ali Rahimi, the founder of ALYKA Health, which uses a personalized mobile app to help patients manage their heart health between doctor's visits. Harlan discusses new developments in GLP-1 obesity drugs, including untested microdose treatments; Howie reviews a landmark study investigating whether broad prostate cancer screening saves lives. Show notes: GLP-1 Drugs "Microdosing aims to extend the lifespan of the GLP-1 compounding market" NIH: Regulatory Framework for Compounded Preparations Health & Veritas Episode 140: Lee Schwamm: Smarter Healthcare Systems With AI "FDA takes on GLP-1 compounding boom with warnings about misleading marketing" "Should You Microdose GLP-1 Drugs?" "How microdosing GLP-1 drugs became a longevity 'craze'" "Bidding war between Pfizer, Novo Nordisk for obesity startup Metsera escalates" "Trump Negotiating Deal With Ozempic Maker to Sell Some Weight-Loss Drugs for $149""Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment" "How Ozempic's Maker Lost Its Shine After Creating a Wonder Drug" Ali Rahimi ALYKA Health Harlan Krumholz and Ali Rahimi, "Financial Barriers to Health Care and Outcomes After Acute Myocardial Infarction" "Why High Blood Pressure Matters to Your Health" Building a Better Delivery System: A New Engineering/Health Care Partnership NIH: The 21st Century Cures Act New Evidence on Prostate Cancer Screening and Breast Cancer Treatment National Cancer Institute: Cancer Stat Facts: Prostate Cancer" U.S. Preventive Services Task Force: Prostate Cancer: Screening" "The pros and cons of PSA tests for prostate cancer for midlife and older men" "Share on European Study of Prostate Cancer Screening — 23-Year Follow-up" "Early Detection of Prostate Cancer — Time to Fish or Cut Bait" "Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer" "Omission of Chest-Wall Irradiation after Mastectomy for Breast Cancer" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.  

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