Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.
High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12.
Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements.
In this episode, you’ll learn:
 • What high homocysteine means and why it matters
 • The connection between homocysteine and methylation
 • Why methylated B vitamins can trigger symptoms
 • Histamine intolerance and supplement sensitivity
 • The role of MTHFR, COMT, and methylation pathways
 • Overmethylation vs undermethylation explained
 • Practical clinical insights for improving tolerance to methyl nutrients
Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing.
Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms.
Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing.
This episode also covers:
 The role of estrogen during menopause and HRT 
 Why over-detoxifying estrogen may worsen symptoms 
 The connection between beta-glucuronidase, the estrobolome, and gut microbiome health 
 Histamine intolerance, hormone imbalance, and menopause symptoms 
 Natural considerations for estrogen metabolism and hormone support 
 Why gut health may be more important than estrogen detox supplements 
If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. 
Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms.
This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms.
You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected.
In this episode, Joanne discusses:
The link between SIBO, histamine intolerance, and hormonal imbalance
Why bloating, PMS, headaches, and acne may stem from gut dysfunction
The difference between hydrogen and methane SIBO
How nutrient deficiencies affect hormones, mood, and energy
Why is bowel motility essential for successful SIBO treatment
The role of biofilms in persistent gut symptoms
Functional medicine strategies for improving gut and hormone health
Whether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation?
In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities.
You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity.
🎧 In this episode, you’ll learn:
 What Epsom salt (magnesium sulfate) actually is 
 How transdermal absorption supports magnesium levels 
 The role of sulfate in liver detoxification (sulfation pathway)
 Why sulfate is essential for gut lining, skin, and connective tissue health
 How Epsom salt baths support the nervous system and stress response
 Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues
 How to safely start Epsom salt baths (especially if sensitive) 
Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system.
This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms.
If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance.
Tune in to learn how to use this simple therapy effectively and safely.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?
In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction.
If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface.

🎧 In this episode, you’ll learn:
What “sulfur intolerance” actually is (and why that term is misleading)
The difference between sulfide, sulfite, and sulfate
How disrupted sulfur metabolism impacts your gut, energy, skin, and brain
The connection between hydrogen sulfide gas and mitochondrial dysfunction
Why sulfur issues can trigger or worsen histamine intolerance
Hidden sources of sulfur in foods, supplements, and water
The role of methylation, molybdenum, and gut bacteria
Key symptoms of sulfur imbalance (including bloating, fatigue, headaches, and food sensitivities)
Many people are told to simply eliminate more and more foods—but what if the real issue isn’t the food itself?
This episode offers a functional medicine perspective to help you understand the deeper biochemical pathways behind your symptoms and why your body may be reacting the way it is.
Understanding sulfur metabolism can completely shift how you approach healing—and may explain why nothing else has worked.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!