Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Have you received an MTHFR gene test result and wondered what it means for your health—or whether you should take methylfolate?
In this replay of one of the Histamine Well Podcast’s five most popular episodes, Joanne explores MTHFR, methylation, folic acid, and folate testing through a clinical lens.
Making sense of genetic results and supplement options can feel overwhelming, especially when you’re navigating ongoing symptoms. This episode looks beyond a single gene result to explore the broader clinical picture, including gut health, testing, and individual responses to supplementation.
In this episode, you’ll explore:
MTHFR and its relationship to methylation.
The different forms of folate and why those differences matter.
Questions to consider before taking methylfolate.
Folate testing and how Joanne approaches it in clinical practice.
Why gut health belongs in the conversation.
The importance of individual assessment when choosing supplements.
Whether you’re trying to understand your own MTHFR results or you’re a practitioner supporting patients with questions about methylation and folate, this replay offers a clinical perspective to help inform the conversation.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Does your histamine bucket feel like it’s overflowing? In this replay of one of the Histamine Well Podcast’s fourth most popular episodes, Joanne explores her approach to managing histamine symptoms while investigating the underlying causes.
If you’re navigating histamine intolerance and symptoms such as headaches, hives, bloating or disrupted sleep, this episode explores dietary strategies and supplement considerations to discuss with your practitioner. Joanne also explains why individual responses matter, particularly when supplements seem to make symptoms worse.
In this episode, Joanne discusses:
A low histamine diet as a short-term strategy while addressing underlying causes.
DAO enzymes and their role in breaking down histamine in food.
Supplement considerations, including quercetin, vitamin C and Saccharomyces boulardii.
The connection between SIBO, histamine symptoms and dietary choices.
Why constipation, digestion and gut motility deserve attention.
Oxalate sensitivity and why further dietary restrictions need individual guidance.
How oestrogen, progesterone and hormonal changes may influence symptoms.
Methylation and why methylated B vitamins may not suit everyone.
Whether you’re new to histamine intolerance or revisiting the foundations, this episode offers insight into Joanne’s clinical approach and questions to explore with your healthcare practitioner.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night?
In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-theanine to support relaxation and explains how timing may differ depending on your symptoms. She also explores combining L-theanine with magnesium and the options she discusses when magnesium glycinate isn’t tolerated.
In this episode, you’ll learn:
How Joanne uses L-theanine for daytime anxiety and nervous system hyperarousal.
When she considers taking it before bed for difficulty falling asleep.
How she approaches L-theanine timing for waking during the night.
The doses and supplement combinations discussed in her clinical approach.
Why individual tolerance matters when choosing magnesium.
If you’ve been wondering when to take L-theanine for anxiety or sleep, this quick episode explores the timing options Joanne considers in practice.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture?
In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions.
The patient had experienced significant bloating, nausea, reflux, constipation and brain fog, with probiotics making her bloating worse. Despite seeing several practitioners, she had not been assessed for SIBO.
Joanne shares the clues that prompted testing, why she prioritised a SIBO breath test over stool microbiome testing in this case, and how she introduced a SIBO low-histamine diet and personalised digestive support.
At her first follow-up, the patient reported an 80% reduction in bloating, alongside improvements in nausea, reflux and heartburn. With constipation still an issue, Joanne explains the next adjustments to her care and why retesting remained part of the plan.
In this episode, you’ll hear:
The patient’s symptom history following food poisoning.
Joanne’s reasoning behind targeted SIBO testing.
How the methane-positive result informed her approach to constipation.
The dietary changes and digestive support used initially.
How Joanne adjusted the plan as symptoms improved.
Her plans for follow-up, retesting and food reintroduction.
Whether you’re experiencing ongoing gut symptoms or supporting patients in clinical practice, this episode offers a practical look at Joanne’s assessment and treatment decisions.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.

In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement.

If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!