Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes.

Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, histamine intolerance, food sensitivities, and chronic illness.

In this episode, you’ll learn:

What the GEMM Protocol is and how it works
How sulforaphane activates the NRF2 pathway and protective genes
Why traditional antimicrobial gut protocols can worsen dysbiosis
How gut inflammation contributes to histamine intolerance and food sensitivities
The role of heat-killed probiotics and immune signaling in gut repair
Why restoring the gut lining can improve conditions throughout the body
How diet and prebiotics support microbiome recovery
 Why some patients with chronic illness react to many supplements

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?

The truth is—it depends.

In this episode, Joanne breaks down the two distinct patient scenarios she commonly sees in clinical practice. She explains when antibiotics may be a practical and supportive option, especially for those with lifestyle limitations, and when a deeper, more comprehensive approach may be necessary to address the root causes of SIBO.

You’ll learn:

When antibiotics can be helpful—and when they may not be enough
Why SIBO often keeps coming back
The role of underlying drivers like gut motility, bile flow, and nervous system health
What a natural, layered approach to healing looks like
How to determine the best path forward for your unique situation
This episode offers a balanced, practical perspective—helping you move beyond one-size-fits-all solutions and toward a more personalized approach to gut healing.

If you’re struggling with recurring SIBO or unsure which direction to take, this conversation will give you clarity and guidance.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?
In this episode of The Histamine Well Podcast, Joanne explains why SIBO rarely develops in isolation and why antibiotics or herbal antimicrobials alone often fail to prevent relapse.
If you’ve been stuck in the cycle of treating SIBO repeatedly without lasting improvement, this episode explores the underlying mechanisms that may be driving bacterial overgrowth in the first place.
Joanne unpacks how impaired gut motility, nervous system dysregulation, low stomach acid, sluggish bile flow, estrogen dominance, mold toxicity, thyroid dysfunction, and histamine intolerance all contribute to creating the perfect environment for SIBO to thrive.
Rather than focusing solely on eliminating bacteria, this episode highlights a terrain-based, root-cause approach to restoring long-term digestive health.

In This Episode, We Discuss:
What SIBO (Small Intestinal Bacterial Overgrowth) actually is
Why SIBO often returns after antibiotics
The migrating motor complex (MMC) and gut motility
The vagus nerve and nervous system regulation
Bile flow and its antimicrobial role
Estrogen dominance and SIBO
Mold toxicity and mitochondrial dysfunction
The connection between SIBO and histamine intolerance
Why relapse happens — and how to prevent it

If you found this episode helpful, please subscribe, leave a review, and share it with someone navigating SIBO or chronic gut issues.
For worldwide online consultations via Zoom, visit: www.joannekennedynaturopathy.com

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fatigue, insomnia, and “wired but tired” patterns.
We also discuss slow COMT activity, the link between estrogen and histamine, and how imbalances can drive mood swings, palpitations, and poor stress tolerance. Discover how real-time methylation testing (Mood Sense saliva swab) can provide personalised insights, plus how to book a Zoom consultation for deeper support.
If you're struggling with histamine intolerance, hormone imbalance, anxiety, or low mood, this episode connects the biochemical dots.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.
H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrowth (SIBO) and rising histamine levels. The result can be a “histamine storm” of inflammation and systemic symptoms.
Common signs may include:
Food reactions
Bloating and gas
Hives or eczema
Anxiety and insomnia
Headaches
PMS, estrogen dominance, and perimenopause flares
Joanne also discusses the pros and cons of triple therapy (antibiotics plus proton pump inhibitors), post-treatment gut repair, and natural strategies such as sulforaphane and gut-healing support.
If your histamine symptoms persist despite dietary changes, this episode explores a deeper gut–histamine–hormone connection that may be driving the root cause.
What You’ll Learn:
How H. pylori disrupts stomach acid and digestion
The link between low stomach acid, SIBO, and histamine intolerance
Why mast cell activation increases systemic symptoms
How histamine impacts estrogen and perimenopause
Treatment considerations and natural support options
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!