Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.

In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement.

If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could your gut help explain why you’re reacting to foods you once tolerated?
In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact.
A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters.
What you’ll learn:
How the intestinal barrier and secretory IgA help protect your gut.
Why microbial diversity, butyrate and immune tolerance matter.
How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.
How mast cells and certain gut bacteria produce histamine.
Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.
How stress, the nervous system, and gut motility can influence digestive symptoms.
Why gut support needs to be personalised to your symptoms and tolerance.
Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one?
In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating.
In this episode:
How food swaps on a low FODMAP diet may increase your sulfur or oxalate intake
Symptoms Joanne suggests watching for alongside bloating
Why the migrating motor complex may matter when bloating persists
Why a SIBO test can help clarify what may be going on
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night.
Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to support a more consistent rhythm, including morning daylight, time outdoors during the day and a darker evening routine.
In this episode, you’ll learn:
What circadian rhythm is and why it matters beyond sleep
How light and darkness influence cortisol and melatonin
Why meal timing may matter for digestion and gut motility
How histamine activity follows a daily pattern
Simple ways to support your body clock within your routine
If you’re navigating histamine intolerance, sleep difficulties, hormone concerns or persistent gut symptoms, this conversation offers another piece of the picture to discuss with your healthcare practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it.

In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects.

You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introduction or different approach may be needed.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!