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NeuroCentury

Podcast NeuroCentury
Paweł Świeboda
The NeuroCentury podcast is a series of conversations about the importance of the brain in the times we live in. Its particular focus is on what can be done, in...

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5 de 22
  • 22. ⁠Ironman Meets Alzheimer's: Endurance for a Cure⁠
    “Surpassing yourself, so that people can surpass the disease” – this is the motto of Hassan Fadli, Founder of “5 Ironman’s Beat Alzheimer’s” non-profit, aiming to promote awareness, prevention and research in the field of dementia (https://www.5ironmansbeatalzheimer.com/en). Hassan is an engineer by training and profession. A couple of years ago, he decided to honour his father, who has recently died of Alzheimer’s Disease (AD), and contribute to the community. Each Ironman race involves 3.86 km of swimming, 180,25 km cycling and 42,20 km of running. It is an exceptional effort, made for an exceptional cause.   In this episode of NeuroCentury, Paweł Świeboda discusses with Hassan Fadli what lies ahead in the brain health campaign. The need for awareness-raising is shown by the recent data from the World Alzheimer Report 2024 (see: https://www.alzint.org/resource/world-alzheimer-report-2024/), which says that 88% of people living with dementia indicate experiencing discrimination. Also, 80% of the general public believes dementia is a normal part of ageing, which it is not (it is a disease). More is known about the importance of prevention with the latest Lancet Commission report raising to 45% the share of dementia cases worldwide, which could potentilly be prevened or delayed by addressing a range of modifiable risk factors. However, prevention still needs to be translated into a lasting change in lifestyles. Research in the neuro space is sinigificantly underfunded compared to other disciplines. As a result, only 2 disease-modifying drugs for AD have been authorised by the US FDA since 2000 as well as 9 symtomatic drugs. In comparison, there have been 573 drugs in oncology. Hassan’s non-profit is conducting a pilot phase of a longitudinal multi-case clinical research study with endurance athletes who are at risk for dementia related diseases focusing on their physical health, mental health, and resilience during sports training and competitions. Endurance is what the fight against AD will need with future cure offering the ultimate reward. neurocentury.com Music for the NeuroCentury podcast is composed by Rafał Kulczycki
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  • 21. Capturing complexity of the brain
    Brain health cannot be easily measured by a single, straightforward test. Evaluations often involve multiple methods. One company which is on a mission to open brain health assessment to the wider public is Myndspan. Its approach integrates cognitive tests with MEG, or magnetoencephalography, analysis. MEG is an advanced brain scanning technique, which can provide a reading of brain activity at high  temporal and spatial resolution. It has the power to identify issues before symptoms emerge. In this episode of NeuroCentury, Paweł Świeboda talks to Caitlin Baltzer, Co-Founder and CEO of Myndspan. Caitlin moved into the brain health space from the world of finance and investment a few years ago, when the potential of MEG technology triggered her interest. Today, Myndspan offers brain health reports, combining an assessment of cognitive function and brain connectivity. It has the ambition of increasing the accessibility of this technology for better brain health. Experts such as Prof. Sylvain Baillett from McGill argue that early MEG brain scanning could be key to forecasting future memory and attention problems. This is because it could read the way amyloid-beta and tau affect brain activity early on, which can predict changes in brain activity when patients experience mild cognitive impairments and AD later in life. In this context, Pawel’s and Caitlin’s conversation explores how brain health assessment methods could be part of a paradigm shift towards early detection and prevention strategies, given that brain disorders tend to be addressed today once symptoms are severe. neurocentury.com Music for the NeuroCentury podcast is composed by Rafał Kulczycki
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  • 20. All-hands-on-deck to build a mentally healthy world
    The challenge of mental health continues to intensify across various demographics and regions. A recent report by Orygen, Australia's Centre of Excellence in Youth Mental Health, highlights a "global crisis" in youth mental health, describing it as unprecedented and urgent. Delivery of care is where large part of the problem lies. United for Global Mental Health assesses the annual mental health financing gap at the level of USD 200 billion. In this episode of NeuroCentury, Paweł Świeboda talks to JULES CHAPPELL, CEO of Kokoro (www.kokorochange.com), organization devoted to building coalitions to create a mentally healthy world. Jules is a former UK diplomat who served in Jordan, Iraq, the US, Ethiopia and Guatemala. She now leads a major philanthropic effort to build a people’s component to the world’s socio-economic transition. Jules and Kokoro are advocates of radical collaboration for mental health with a global network of allies, partners and funders. The conversation explores factors that contribute to the mental health crisis, ranging from the influence of social media, insecure employment, reduced access to affordable housing and fears around climate change. It is also about positive developments such as how mental health is beginning to be treated in the workplace, with many companies offering mental health days, flexible working hours, on-site counseling, and comprehensive mental health benefits. Jules argues that we often have a blind spot for mental health and this needs to change. Just as most leaders know what they need to do on climate, they need to know the same for mental health. neurocentury.com Music for the NeuroCentury podcast is composed by Rafał Kulczycki
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  • 19. Acting on climate to protect the brain
    “The climate crisis is a health crisis, but for too long, health has been a footnote in climate discussions” – these words of the WHO Director-General Dr. Tedros Adhanom Ghebreyesus hold true for brain health as well. However, we are only beginning to understand how the changing climate is negatively impacting the human brain. Emerging evidence suggests that excessive heat can be severely damaging. Heat stress often leads to neuroinflammation, oxidative stress, brain ischemia or neuronal damage. This can result in the worsening of the neurological disease symptoms, increased mental distress, or cognitive dysfunction. Burcin Ikiz, who is Paweł Świeboda’s guest in this episode of the NeuroCentury podcast, is an award-winning neuroscientist working on neurodegenerative diseases, a founder and chair of the International Neuro Climate Working Group. As of 2023, she leads EcoNeuro, a research initiative dedicated to exploring the intersection of neuroscience and climate change for global health advancement. She leads many global initiatives aimed at addressing the link between climate change and brain health. The conversation addresses the existing evidence with respect to the impact of climate and environmental pollution on the brain, as well as gaps in our understanding which require further research. It explores the mechanisms of action when pollutants enter the brain, the importance of taking both outdoor and indoor pollution into account, patient-driven research, the data which is needed to study the impact of the environment and climate on the brain, evidence-based interventions that will significantly improve outcomes of environmentally related mental illnesses, and the importance of international collaboration. At the end of the exchange, Burcin shares a few great tips for a brain health routine.   neurocentury.com Music for the NeuroCentury podcast is composed by Rafał Kulczycki
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  • 18. All Around the Brain: Interplay Between the Brain and its Environment
    The brain does not function in isolation and there is a growing body of knowledge about the impact of environmental and social challenges on brain health. Air and water pollution, and exposure to plastics, heavy metals, and other toxic substances have a bearing on the brain. Similarly, the impact of inequality and disparity in income, education, and access to healthcare is significant. There is merit in studying the exposome, that is all exposures individuals encounter throughout their lifetime. In this episode of NeuroCentury, Paweł Świeboda talks to Prof. Agustin Ibáñez, Director of the Latin American Brain Health Institute at Universidad Adolfo Ibáñez and Professor in Global Brain Health at Trinity College Dublin. Agustin is the main author of a recent paper in Neuron on “Neuroecological links of the exposome and One Health”  He is founder and codirector of the ReDLat consortium aimed at fighting dementia collaboratively. The conversation explores Agustin’s work on the environmental and social exposome, including how it can accelerate brain aging. The brain clock does not tick in a universal, linear fashion but instead captures the entropic, transient nature of time, Agustin says. It ages differently depending on the environment in which it is embedded. Interventions need to be tailored accordingly, but they inevitably have to be long-term and multi-level, given the interrelationship between impacts.  NeuroCentury.com  Music for the NeuroCentury podcast is composed by Rafał Kulczycki
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Sobre NeuroCentury

The NeuroCentury podcast is a series of conversations about the importance of the brain in the times we live in. Its particular focus is on what can be done, including in policy, to advance the brain agenda: look after our brain and mental health, support brain-derived technology, or develop our societies’ cognitive skills. Guests range from patients, technologists, scientists, ethicists, policy-makers, to investors and funders. The podcast is hosted by Paweł Świeboda, who combines his policy and science management experience to ask what it will mean to live in the century of the brain.
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