Primary Care Update

Primary care physicians Kate, Mark, Henry and Gary discuss 4 new studies that could change your practice: treatments for hyperemesis gravidarum, calcium and vitamin D to prevent falls and fractures in older adults, the first oral PCSK9 inhibitor, and oral semaglutide to treat dementia .
The John Hickner Memorial fund at MSU: https://give.msu.edu/?sid=17374
Hyperemesis gravidarum treatments: https://pubmed.ncbi.nlm.nih.gov/41478546/
Supplementing with calcium or vitamin D: https://pubmed.ncbi.nlm.nih.gov/42161415/
Oral PCSK-9 enlicitide:  https://pubmed.ncbi.nlm.nih.gov/41879224/
Cochrane review of PCSK-9s: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011748.pub3/full
Semaglutide for dementia: https://pubmed.ncbi.nlm.nih.gov/41865758/

This week, Kate, Gary and Mark discuss 3 new studies: whether we can do anything about modifiable risk factors for dementia, whether COVID-19 vaccines are still useful, and how to interpret abnormal shoulder MRIs.

Primary care docs Kate Rowland, Mark Ebell, Henry Barry and Gary Ferenchick talk about 4 new studies: prevention of multimorbidity in people at high risk of diabetes, high-dose vitamin D in healthy older adults, whether screening for skin cancer reduces melanoma mortality, and tirzepatide withdrawal and weight maintenance .

Join primary care professors Mark Ebell, Kate Rowland, Gary Ferenchick and Henry Barry as they discuss 4 new studies: semaglutide for alcohol use disorder, a vibrating cool pack to prevent post vaccination syncope, PCR for 23 respiratory pathogens in primary care to reduce antibiotic use, and fluvoxamine for Long-COVID Fatigue.
Links
Semaglutide for AUD: https://pubmed.ncbi.nlm.nih.gov/42070571/
Vibrating cool pack for vaccine syncope: https://pubmed.ncbi.nlm.nih.gov/41692229/
Point of care PCR for acute RTI: https://pubmed.ncbi.nlm.nih.gov/42149561/
Likelihood that pathogen is commensal vs pathogenic: https://pubmed.ncbi.nlm.nih.gov/39864052/
Fluvoxamine and long COVID: Ann Intern Med. 2026;179(5):621-628  https://pubmed.ncbi.nlm.nih.gov/41911553/

This week primary care physicians Kate Rowland, Mark Ebell, Gary Ferenchick and Henry Barry discuss four new studies: screentime for children, discontinuing levothyroxine, a new mRNA flu vaccine from Moderna, and nicotinamide adenine dinucleotide (NAD) Supplementation for healthy aging.
Links to articles:
AAP screen time policy
Discontinuing levothyroxine study
mRNA flu vaccine from Moderna
NAD supplements
Quiz: Bixomania study