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The Mind-Gut Conversation Podcast

Emeran Mayer, MD
The Mind-Gut Conversation Podcast
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  • How Food Influences Our Mood and Mental Health with Felice Jacka, OAM | MGC Ep. 100
    Dr. Emeran Mayer welcomes Professor Felice Jacka, founder of the Food & Mood Centre and a global leader in nutritional psychiatry, for an in-depth discussion on how diet influences mental health and brain function.Felice shares the groundbreaking research that launched an entire field, from the first studies linking diet quality to depression, to clinical trials demonstrating how dietary changes can improve major depressive disorder. She also takes us beyond the plate, showing how agriculture, soil health, and food systems play a critical role in shaping both human and planetary health.You’ll also hear about her efforts to bring nutritional psychiatry into medical guidelines and education worldwide, and why simple, evidence-based changes, like cutting back on ultra-processed foods and adding more whole grains and legumes, can profoundly affect mood and resilience.Key Topics Covered:• What is nutritional psychiatry and why it matters• How dietary patterns influence depression, anxiety, and cognition• The SMILES and CALM trials: diet as a therapeutic tool• The impact of ultra-processed foods on the microbiome and brain• How soil biodiversity affects nutrient density and mental health• Practical, evidence-based dietary shifts for everyday lifeThis conversation offers both hope and clarity: by improving diet quality, we can not only enhance individual mental health but also address the broader challenges of food systems and planetary well-being.As always, please leave any questions or comments below. We hope you enjoy the episode!Connect with Dr. Mayer:Website: ⁠emeranmayer.com⁠Instagram: ⁠@emeranmayer⁠X: ⁠@EmeranMayerMD⁠YouTube: ⁠Emeran Mayer, MD⁠Chapters:00:00 Introduction to Nutritional Psychiatry05:50 The Complexity of Food and Mental Health11:59 The Impact of Industrial Food Systems18:06 Lifestyle Interventions in Mental Health Treatment30:18 Nutritional Psychiatry Training and Resources38:13 Evidence of Dietary Interventions in Mental Health45:49 Challenges in Changing Dietary Habits57:24 Whole Grains: The Key to Better Health
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  • The Mitochondrial Key to Longevity, Stress, & Holistic Health with Martin Picard, PhD | MGC Ep. 99
    Dr. Emeran Mayer welcomes Martin Picard, PhD, mitochondrial biologist and systems thinker, for a fascinating conversation on the hidden role of mitochondria in health, stress, and consciousness.Martin explains how mitochondria, far beyond being simple “powerhouses of the cell”, are dynamic regulators of energy, emotion, and resilience. He explores their symbiotic relationship with the gut microbiome and how this ancient partnership influences inflammation, mental health, and overall well-being.You’ll also hear about Martin’s concept of “intrinsic health,” a field-like state that integrates biology, energy flow, and human experience. Together, he and Dr. Mayer discuss why understanding energy as the potential for change may reshape how we think about health, stress, and even consciousness itself.Key Topics Covered:• The evolutionary story of mitochondria and their link to the gut microbiome• Why energy is best understood as flow rather than a fixed resource• The impact of stress on mitochondrial health and resilience• How intrinsic health connects science with lived experience• A new paradigm for understanding mental and physical well-beingDiscover how mitochondria and the microbiome together form the foundation of vitality, and why a holistic, systems-based view of health is essential for true well-being. Enjoy!Connect with Dr. Mayer:Website: ⁠emeranmayer.com⁠Instagram: ⁠@emeranmayer⁠Twitter/X: ⁠@EmeranMayerMD⁠YouTube: ⁠Emeran Mayer, MD⁠Episode Chapters:00:00 Introduction to Mitochondria and Microbiome05:26 The Evolutionary Significance of Mitochondria10:35 Energy Dynamics in Biological Systems15:30 Consciousness and Energy: A Philosophical Exploration20:51 The Human Experience and Health22:37 Bridging Biology and Human Experience23:31 Mitochondria and Human Emotions25:28 The Complexity of Mental Health28:58 Intrinsic Health: A New Paradigm36:21 Measuring Intrinsic Health46:10 Stress, Energy, and Health
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  • The Secrets Behind the World's Longest Living People with Dan Buettner | MGC Ep. 98
    Dr. Emeran Mayer welcomes Dan Buettner, National Geographic explorer, Emmy award-winning filmmaker, and founder of the Blue Zones, for an illuminating conversation on the secrets of longevity.Dan explains why people in Blue Zone communities, like Ikaria, Greece, and Nicoya, Costa Rica, live significantly longer, healthier lives, and why it has little to do with genetics. Instead, he shares how their environments naturally support better choices: more movement, plant-based eating, strong social ties, and a deep sense of purpose.You’ll also hear about the proven success of Blue Zone initiatives in U.S. cities like Fort Worth and Los Angeles, where simple changes in policy and urban design have reduced obesity and improved community health. Dan also tackles popular longevity “hacks,” the importance of happiness, and why beans may be the most powerful superfood on your plate.Key Topics Covered:• The origins and science behind the Blue Zones• Diet and lifestyle patterns that extend life by up to a decade• Why changing your environment beats trying to change your willpower• How happiness and community are linked to health• What U.S. cities can learn from the world’s healthiest populationsDiscover the evidence-based practices that can help you live longer, healthier, and happier starting today.Connect with Dr. Mayer:Instagram: ⁠@emeranmayer⁠Twitter/X: ⁠@EmeranMayerMD⁠YouTube: ⁠Emeran Mayer, MD⁠Website: ⁠emeranmayer.com⁠TIMESTAMPS:0:00 - 0:51 Introduction0:51 - 2:13 Who is Dan Buettner?2:13 - 4:47 What explains longevity in the Blue Zones?4:47 - 7:02 This is a fake Blue Zone7:02 - 10:00 Blue Zone diet/lifestyle10:00 - 13:15 Our bodies aren't optimized for our modern lifestyle13:15 - 15:20 Modern medicine & epidemic of chronic disease15:20 - 17:57 Why is Singapore so healthy?17:57 - 19:20 Thoughts on MAHA movement19:20 - 21:11 Transforming US cities into Blue Zones21:11 - 22:52 Are certain longevity factors more important than others?22:52 - 24:35 What kind of diet does Dan follow24:35 - 27:36 Thoughts on biohacking, rapamycin, metformin27:36 - 29:02 Dan's new book - Blue Zone Kitchen29:02 - 32:08 Issues with an older & older population32:08 - 33:40 Relationship between longevity & happiness33:40 - 34:37 Thanks for listening
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  • Understanding Sex Differences in Stress and Gut Health | MGC Ep. 97
    Dr. Mayer unpacks groundbreaking research on how men and women differ in their responses to stress, emotional stimuli, and gut sensations. Drawing from studies at UCLA’s Oppenheimer Center, the conversation highlights key differences in brain-gut communication, revealing how neural pathways influence both emotional and physical health.You’ll learn why women are more prone to conditions like IBS, how heart rate variability reflects emotional processing, and why men tend to show more action-oriented responses to stress. Dr. Mayer also explores the growing potential of personalized therapy—tailored to biological and psychological differences—to transform how we treat chronic gut-brain conditions.Key Topics Covered:• Sex-based differences in stress response patterns• Brainstem connectivity and gut sensitivity• Emotional awareness and heart rate variability• Chronic disease and the gut-brain connection• Personalized therapies based on genderUnderstanding these sex-based differences isn’t just fascinating—it’s essential for developing more effective, tailored approaches to brain-gut health. Tune in to explore how science is reshaping the way we treat mind and body together.Connect with Dr. Mayer:Website: ⁠⁠emeranmayer.com⁠⁠Instagram: ⁠@emeranmayer⁠Twitter/X: ⁠@EmeranMayerMD⁠YouTube: @EmeranMayerMD
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  • The SIBO Myth: What Clinicians & Patients Should Know | MGC Ep. 96
    SIBO—Small Intestinal Bacterial Overgrowth—has become a buzzword in the gut health space, often blamed for symptoms like bloating, gas, and fatigue. But how much of the hype is supported by solid science?In this episode of The Mind-Gut Conversation, Dr. Mayer critically examines the growing SIBO narrative. Drawing from decades of clinical experience and the latest peer-reviewed evidence, he breaks down what SIBO actually is, who it truly affects, and why breath tests and antibiotic treatments like rifaximin are far less reliable—and more commercially driven—than many believe.In this episode, you’ll learn:Why true SIBO is rare and typically linked to structural or motility disordersWhy current diagnostic tests are flawed and often misusedHow intestinal gas production is a normal part of digestion—not necessarily a problemWhy rifaximin may relieve symptoms without ever addressing SIBOThe role of microbial diversity, short-chain fatty acids, and the broader brain-gut microbiome systemWhether you’ve been diagnosed with SIBO or are simply curious about one of the most misunderstood topics in gut health, this episode separates myth from medicine.Thank you for your interest!--------------Connect with Dr. Mayer:Instagram: @emeranmayerTwitter/X: @EmeranMayerMDYouTube: Emeran Mayer, MDWebsite: emeranmayer.com
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Sobre The Mind-Gut Conversation Podcast

The Mind-Gut Conversation brings in experts within various fields of health & science to have a discussion with world-renowned gastroenterologist, neuroscientist and bestselling author of The Mind Gut Connection, Emeran Mayer, MD.
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