LONGEVITY with Nathalie Niddam

Today, I’m joined by Kyal Van Der Leest, an innovative naturopath, nutritionist, and founder of LVLUP Health, whose formulas are changing the way we think about effective supplementation. Kyal’s journey is deeply personal: from caring for his mother through a long battle with cancer, to overcoming his own intense health struggles with mold illness. These experiences led him to push past superficial fixes and dig deep into what really works for healing and optimizing the body.

Visit www.lvluphealth.com and use code NAT for 20% off

Previous Episodes: 

Episode #116: Does the Perfect Gut Supplement Exist?

Episode #148: Kyal Van Der Leest: Liver Health, Gut Health, and Detoxification

#326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest

Episode Timestamps:

Welcome & Podcast intro ... 00:00:00

Pitfalls of cheap supplements & importance of quality ... 00:05:33

Mistakes: symptom chasing, green allopathy, and root causes ... 00:07:38

Blending naturopathy, biochemistry, and biohacking ... 00:10:26

Choosing peptides, herbs, or vitamins for target outcomes ... 00:16:43

Synergy, proprietary blends, and dosing transparency ... 00:18:06

Understanding supplement forms, dosages, and stack simplification ... 00:24:29

Root cause thinking: brain fog, labs, and interconnected symptoms ... 00:34:16

Dopamine, focus, and the risks of overstimulation ... 00:39:59

Peptides in brain health—a step beyond herbs or nutrients ... 00:43:00

Short-term nootropics vs. long-term investments in brain health ... 00:46:17

Longevity levers: muscle, blood sugar, and blood flow ... 00:51:04

Blood sugar regulation—berberine, dihydroberine, and alternatives ... 00:53:32

Liver’s core role in hormones and energy ... 00:55:59

Heart and lung health—peptides, circulation, and overlooked systems ... 01:00:10

Peptides vs. herbs—when to choose and when to avoid ... 01:04:21

Future of peptides, supplement quality, and industry direction ... 01:07:45

Hierarchy: Foundations before biohacks ... 01:08:57

Simple, high-impact upgrade picks & final advice ... 01:11:17

Industry trends, influencer issues, and episode wrap ... 01:17:01

Where to find Kyal and promo code details ... 01:19:19

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Dr. Bill Lawrence Episode

Today, I'm joined by Dr. Taz Bhatia, a trailblazing integrative medicine physician, entrepreneur, and leading voice in women's health and longevity. In our conversation, Dr. Taz opens up about how her personal health challenges as a conventionally-trained MD led her to explore nutrition, Chinese medicine, and Ayurveda, inspiring her to reimagine what it means to truly care for the whole person.

We also dive into the work of Countdown, a nonprofit accelerating mitochondrial science and medicine to improve how we prevent and treat disease. If you’re interested in women’s health, functional medicine, healthy aging, and cellular energy, this episode is packed with valuable insights.

Episode Timestamps:

Introduction to Longevity Podcast and host ... 00:00:00

Introducing Dr. Taz Bhatia and Countdown’s mission ... 00:01:10

Limitations of conventional medicine and time with patients ... 00:08:03

Holistic approach: importance of deep intakes and history ... 00:10:09

Cellular energy and why it matters now ... 00:11:38

Modern lifestyle threats to cellular and mitochondrial health ... 00:12:27

Rising chronic inflammation and age-related diseases ... 00:13:05

Missed opportunities: not measuring or prioritizing cell health ... 00:14:01

Inherited and childhood mitochondrial issues ... 00:15:13

Impact of earlier mitochondrial research on current medicine ... 00:20:12

Manifestations of mitochondrial aging in elderly and kids ... 00:22:15

Women’s health: chronic stress, hormone decline, and autoimmunity ... 00:26:40

Risks of hormone treatment without cell health basics ... 00:37:41

Underfunding of women’s health research and its clinical impact ... 00:40:34

Mitochondria’s direct link to hormone and overall health ... 00:45:02

Countdown: accelerating mitochondrial research and awareness ... 00:46:16

Ovarian aging’s role in female longevity ... 00:48:02

Future of medicine: better testing, integration, and support ... 00:54:55

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Dr. Bill Lawrence Episode

Today, I’m flying solo to tackle a topic that’s essential for anyone invested in their health: how to truly vet your supplements. With new products hitting the shelves daily and wellness marketing louder than ever, it’s easy to get swept up in the latest hype—but more isn’t always better, and sometimes it can actually make things worse.

Episode Timestamps:

Welcome and podcast introduction ... 00:00:00

Baseline biomarker testing before supplementing ... 00:04:21

Risks with supplementing without testing ... 00:06:06

Third-party certification for supplement quality ... 00:08:18

Supplement contamination issues ... 00:08:55

Seals to look for and their limits ... 00:09:54

Efficacy and scientific evidence hierarchy ... 00:10:53

Limitations of animal/cell data vs. human trials ... 00:13:05

Red flags in supplement marketing ... 00:15:12

"Natural" isn’t always safe—drug interactions and toxicity ... 00:15:58

Fat-soluble vitamin risks and safe disclosure ... 00:18:12

Form and bioavailability importance ... 00:21:07

Optimal vs. poor supplement forms ... 00:21:25

Timing, combinations, and activated forms ... 00:23:13

Dose: fairy dusting, blends, and megadosing dangers ... 00:25:15

Checklist summary for supplement decisions ... 00:31:25

Conclusion and disclaimer ... 00:33:03

Our Amazing Sponsors:

Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off.

Apollo Neuro — A wearable nervous system support device that uses personalized SmartVibes technology to help you feel calmer, more focused, and better able to shift into rest mode without adding another complicated wellness routine. Head to apolloneuro.com/NATN Offer to receive 20% off. 

Ultimate GI Repair by LVLUP Health — a research-backed blend of peptides, zinc carnosine, and gut-support compounds designed to strengthen your gut lining, improve digestion, and support resilience from the inside out; head to lvluphealth.com and use code NAT for 20% off

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Dr. Bill Lawrence Episode

Today, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift.

Episode Timestamps:

Introduction and host welcome ... 00:00:00

Introducing Speaker B and focus on women’s health ... 00:04:30

Growing interest in women’s health and clinical gaps ... 00:05:12

Body composition and metabolic changes in perimenopause ... 00:06:01

Hormonal shifts—not a broken metabolism ... 00:09:21

Addressing the root cause versus band-aids like GLP-1 ... 00:11:10

What’s happening beneath the surface in early perimenopause ... 00:12:40

Role of estrogen in appetite, glucose, and fat storage ... 00:13:12

Visceral fat, inflammation, and accelerated aging ... 00:15:02

Estrogen’s connection to mitochondrial function ... 00:16:15

Brain, muscle, and cognitive declines with estrogen loss ... 00:16:44

Environmental and mitochondrial factors in PCOS ... 00:21:09

Shift to belly fat and why fat storage changes ... 00:22:58

Mitochondria, immune system, and autoimmunity in women ... 00:29:16

Phytoestrogens, soy, and S-equol as hormone alternatives ... 00:32:37

S-equol’s benefits: metabolic, bone, and brain health ... 00:35:50

Soy fears, GMOs, and the purity of S-equol ... 00:46:25

Microbiome, Bifidobacterium breve, and estrogen recycling ... 00:49:18

GLP-1s versus supporting the root cause ... 00:53:01

Optimizing estrogen signaling for health span and menopause timing ... 00:55:20

When to use S-equol: timing and benefits ... 00:55:54

Reversing visceral fat and lifestyle factors ... 01:03:28

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Dr. Bill Lawrence Episode

Today, I’m joined by Andrea Donsky, a powerhouse nutritionist, menopause advocate, and author of the groundbreaking new book Nourishing Menopause. In our conversation, Andrea opens up about her deeply personal journey—how experiencing her first hot flash as a nutrition expert pushed her into years of curiosity, research, and ultimately, a mission to reimagine menopause as both a challenge and an opportunity.

Episode Timestamps:

Welcome, show intro, and purpose ... 00:00:00

Lack of menopause awareness and connecting symptoms ... 00:07:02

Mainstream vs. holistic menopause approaches ... 00:09:09

Surveying thousands of women and symptom discovery ... 00:11:16

Validating unusual menopause symptoms ... 00:13:41

Impact on relationships and the workplace ... 00:21:04

Early onset, variability, and importance of hormonal testing ... 00:25:32

Key takeaways: you’re not alone, support exists ... 00:28:16

Ovarian aging and overall health ... 00:29:47

Shifts in women’s health research ... 00:32:11

Designing impactful, diverse menopause surveys ... 00:33:41

Andrea’s “Nourishing Menopause” book philosophy ... 00:35:12

Nourishment, longevity, and healthspan ... 00:37:23

Risks of muscling through menopause ... 00:39:52

Insulin resistance: causes, signs, and management ... 00:45:57

Meal timing, fasting, and metabolic flexibility ... 00:51:06

Personalized health testing and nutrition ... 00:56:0

Soy/phytoestrogen controversy ... 00:58:08

BALANCE blueprint and nutrition pillars ... 01:01:18

Managing stress, nervous system, and reframing menopause ... 01:05:31

Andrea’s non-negotiables and top practical tips ... 01:09:11

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Dr. Bill Lawrence Episode