Physiologically Speaking

Greetings!Happy Black Friday to those who celebrate.Are you looking for a new health, fitness, or nutrition product for yourself or to give as a gift to family and friends? Here are a few Black Friday/Cyber Monday deals from brands I’m affiliated with and use myself.Save up to 60% on an Examine.com membershipGet 30% off of your Ketone-IQ purchase30% off of FSTFUEL electrolytes with the code BRADY30 at checkout30% off of Presleep sleep supplement with the code BRADY30 at checkout10% off of a Pedal Industries Race Day bag with the code INF-BRADY at checkoutGet Decaf Drip coffeeAdditionally, for a limited time, you can snag a yearly subscription to Physiologically Speaking for $39.99 (originally $50) or purchase a subscription for a friend or family member as a gift.Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Today, instead of a new study, I’m sharing the video of a podcast appearance I made on The Mind Muscle Connection with Jeff Hoehn.We talk about:* Research* Endurance exercise performance* Sleep* Training & nutrition* Supplements* Cardio* Recovery* Calorie intake* Metabolism* Aerobic exercise training* Exercise volume and intensity* How to measure improvements in cardiovascular fitness* My 7 rules for health* And more!* Be sure to check out Jeff’s podcast, subscribe, and give him a follow on Instagram and X.Thanks so much for subscribing. I’m grateful to every one of my audience members!~Brady~ This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe

Greetings!David Roche is a decorated trail runner, coach, and co-founder of SWAP Running. He's a two-time national champion and a three-time Team USA member, and he recently set the course record at the Leadville 100 trail run with a time of 15 hours, 26 minutes, 34 seconds.David and his wife, Megan Roche, M.D., offer coaching that blends science, training theory, and a philosophy of joy and long-term growth for all athletes. Megan just launched a website—Huzzah—“to empower female endurance athletes by providing accessible sports science knowledge and fostering a love for sport through content, insights, and scholarships, with a focus on supporting overall health, education, and competitive edge.”I’ve become a bit obsessed with how David thinks about running and how invested he and Megan are in reading and implementing the science of training and racing. So I needed to nerd out with him on some topics.In this interview, I picked David’s mind about his scientific approach to training, and we detail several of the training practices he used in his buildup to the race, including:Sodium bicarbonateDownhill runningHigh-carb fuelingSuper shoesPost-exercise exogenous ketonesHeat training/hot water immersionCaffeineHeart rate zonesAnd more!Relevant linksFor more details about David and SWAP Running, visit their About Us pageFollow David on X @MountainRocheWatch the documentary about David’s record: Leadville 100 Ultramarathon & David Roche's Run for The Impossible Record This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe

Greetings friends!In this interview, I sit down with Christina Smith, the Associate Director of Athlete Relations for the Enhanced Games.Per the Enhanced Games website:“The Enhanced Games are a celebration of the union of athletic excellence and scientific achievement.The Enhanced Movement believes in the medical and scientific process of elevating humanity to its full potential, through a community of committed athletes.”Some are calling the Enhanced Games the “Enhanced Olympics” — but I think that this movement is more than just that. After attending numerous press conferences and doing this interview with Christina, I think that the Enhanced Games has the chance — if executed correctly — to change the way that we watch sports (and the way that athletes compete in them).Due to a few issues with recording, the first 10 minutes of this interview are audio only. But the rest of the interview is video.Enjoy! This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe

Greetings!Today’s interview is with Andrew Koutnik, Ph.D. Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes.Andrew is unique because he himself has type 1 diabetes. This allows him to add a bit of personal touch and a lot of passion into the work he’s doing.Andrew joins me to talk about a case study (two papers) that he and colleagues just published on the long-term safety and efficacy of the ketogenic diet for an individual with type 1 diabetes who had been using the ketogenic diet for more than 10 years (spoiler alert: it’s Andrew).We talk about why the ketogenic diet is helpful for people with diabetes and then dive into the details of each study to explore how 10 years on the diet affected cardiovascular health risk factors and clinical biomarkers.Andrew posted two great threads about the papers on X. You can check those out below. Make sure to give Andrew a follow as well while you’re there.Part I: 10-Years longitudinal data on KETOGENIC DIET and Safety, Efficacy & Advanced Cardiovascular Physiology in a patient with HIGH RISK cardiovascular disease (Type 1 Diabetes)?Part II: 10-Year Longitudinal Data On Ketogenic Diet Adverse Events, Bone Mineral Density, Thyroid Function, and Kidney FunctionHere are the links to each paper:Advanced Cardiovascular Physiology in an Individual with Type 1 Diabetes After 10-Year Ketogenic DietEfficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe