Powered by RND
PodcastsSaúde e fitnessPhysiologically Speaking
Ouça Physiologically Speaking na aplicação
Ouça Physiologically Speaking na aplicação
(1 200)(249 324)
Guardar rádio
Despertar
Sleeptimer

Physiologically Speaking

Podcast Physiologically Speaking
Brady Holmer
A weekly podcast highlighting recent research in science. www.physiologicallyspeaking.com
Veja mais

Episódios Disponíveis

5 de 19
  • Physiology Friday #246: Black Friday Discount + My Conversation on The Mind Muscle Connection Podcast
    Greetings!Happy Black Friday to those who celebrate.Are you looking for a new health, fitness, or nutrition product for yourself or to give as a gift to family and friends? Here are a few Black Friday/Cyber Monday deals from brands I’m affiliated with and use myself.Save up to 60% on an Examine.com membershipGet 30% off of your Ketone-IQ purchase30% off of FSTFUEL electrolytes with the code BRADY30 at checkout30% off of Presleep sleep supplement with the code BRADY30 at checkout10% off of a Pedal Industries Race Day bag with the code INF-BRADY at checkoutGet Decaf Drip coffeeAdditionally, for a limited time, you can snag a yearly subscription to Physiologically Speaking for $39.99 (originally $50) or purchase a subscription for a friend or family member as a gift.Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Today, instead of a new study, I’m sharing the video of a podcast appearance I made on The Mind Muscle Connection with Jeff Hoehn.We talk about:* Research* Endurance exercise performance* Sleep* Training & nutrition* Supplements* Cardio* Recovery* Calorie intake* Metabolism* Aerobic exercise training* Exercise volume and intensity* How to measure improvements in cardiovascular fitness* My 7 rules for health* And more!* Be sure to check out Jeff’s podcast, subscribe, and give him a follow on Instagram and X.Thanks so much for subscribing. I’m grateful to every one of my audience members!~Brady~ This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe
    --------  
    1:16:46
  • How Ultrarunner David Roche Uses Science to Break Records
    Greetings!David Roche is a decorated trail runner, coach, and co-founder of SWAP Running. He's a two-time national champion and a three-time Team USA member, and he recently set the course record at the Leadville 100 trail run with a time of 15 hours, 26 minutes, 34 seconds.David and his wife, Megan Roche, M.D., offer coaching that blends science, training theory, and a philosophy of joy and long-term growth for all athletes. Megan just launched a website—Huzzah—“to empower female endurance athletes by providing accessible sports science knowledge and fostering a love for sport through content, insights, and scholarships, with a focus on supporting overall health, education, and competitive edge.”I’ve become a bit obsessed with how David thinks about running and how invested he and Megan are in reading and implementing the science of training and racing. So I needed to nerd out with him on some topics.In this interview, I picked David’s mind about his scientific approach to training, and we detail several of the training practices he used in his buildup to the race, including:Sodium bicarbonateDownhill runningHigh-carb fuelingSuper shoesPost-exercise exogenous ketonesHeat training/hot water immersionCaffeineHeart rate zonesAnd more!Relevant linksFor more details about David and SWAP Running, visit their About Us pageFollow David on X @MountainRocheWatch the documentary about David’s record: Leadville 100 Ultramarathon & David Roche's Run for The Impossible Record This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe
    --------  
    1:29:02
  • Enhanced Games Interview
    Greetings friends!In this interview, I sit down with Christina Smith, the Associate Director of Athlete Relations for the Enhanced Games.Per the Enhanced Games website:“The Enhanced Games are a celebration of the union of athletic excellence and scientific achievement.The Enhanced Movement believes in the medical and scientific process of elevating humanity to its full potential, through a community of committed athletes.”Some are calling the Enhanced Games the “Enhanced Olympics” — but I think that this movement is more than just that. After attending numerous press conferences and doing this interview with Christina, I think that the Enhanced Games has the chance — if executed correctly — to change the way that we watch sports (and the way that athletes compete in them).Due to a few issues with recording, the first 10 minutes of this interview are audio only. But the rest of the interview is video.Enjoy! This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe
    --------  
    42:22
  • The Case for Keto for Type 1 Diabetes with Andrew Koutnik, Ph.D.
    Greetings!Today’s interview is with Andrew Koutnik, Ph.D. Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes.Andrew is unique because he himself has type 1 diabetes. This allows him to add a bit of personal touch and a lot of passion into the work he’s doing.Andrew joins me to talk about a case study (two papers) that he and colleagues just published on the long-term safety and efficacy of the ketogenic diet for an individual with type 1 diabetes who had been using the ketogenic diet for more than 10 years (spoiler alert: it’s Andrew).We talk about why the ketogenic diet is helpful for people with diabetes and then dive into the details of each study to explore how 10 years on the diet affected cardiovascular health risk factors and clinical biomarkers.Andrew posted two great threads about the papers on X. You can check those out below. Make sure to give Andrew a follow as well while you’re there.Part I: 10-Years longitudinal data on KETOGENIC DIET and Safety, Efficacy & Advanced Cardiovascular Physiology in a patient with HIGH RISK cardiovascular disease (Type 1 Diabetes)?Part II: 10-Year Longitudinal Data On Ketogenic Diet Adverse Events, Bone Mineral Density, Thyroid Function, and Kidney FunctionHere are the links to each paper:Advanced Cardiovascular Physiology in an Individual with Type 1 Diabetes After 10-Year Ketogenic DietEfficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe
    --------  
    1:03:37
  • Physiology Friday #214: Strengthening the Link Between V̇O2 Max and Longevity & Healthspan
    Greetings!Welcome to the Physiology Friday newsletter.ICYMICheck out my guest appearance on The Neuro Experience podcast with Louisa Nicola, where we talk about the science of V̇O2 max.On Wednesday, I published a post about some of the most common myths about coffee and caffeine.Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials” can be found at the end of the post!Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.If you can fill the unforgiving minute With sixty seconds’ worth of distance run, Yours is the Earth and everything that’s in it, And—which is more—you’ll be a Man, my son!— Rudyard Kipling, If—In my book “VO2 Max Essentials”, I make the case for why cardiorespiratory fitness should be considered the most important vital sign. Among all risk factors, V̇O2 max is the only one that’s a composite of multiple physiological systems, rather than a snapshot of health at one point in time or a single biomarker measured via a blood test.Your maximal oxygen utilization capacity (V̇O2 max) represents the maximum integrated capacity of the pulmonary, cardiovascular, and muscular systems to uptake, transport, and utilize oxygen during whole-body, dynamic exercise. The function of your autonomic nervous system, your heart and blood vessels, your lungs, your muscles, and your mitochondria all influence your maximal aerobic capacity. It’s not just a strong heart that gives someone a high V̇O2 max. A strong body is a prerequisite.This is, in my opinion, why a high V̇O2 max is so often associated with beneficial health outcomes. You won’t find someone with a high V̇O2 max who is in poor health, and often people with an extremely low V̇O2 max are in poor health.Though it’s not routinely measured in clinical practice (yet), V̇O2 max has recently appeared on the radar of many healthcare professionals. People are becoming aware of the predictive power of cardiorespiratory fitness and are increasingly interested in how (and why) to improve it.Over the last 20 years, evidence has emerged linking higher cardiorespiratory fitness to lower risks of all-cause mortality and other diseases. Thus, it’s about time we had a scoping review of the evidence, which brings us to today’s study.The study, published in the British Journal of Sports Medicine was an overview of all previously published systematic reviews and meta-analyses on the relationship between V̇O2 max and an array of health outcomes.The studies were eligible if they included adults with or without health conditions and measured cardiorespiratory fitness using a maximal graded exercise test, a maximal or submaximal exercise test with a prediction equation (i.e., without direct measures of gas exchange), or a non-exercise prediction equation. When pooling the data and examining the outcomes, the authors compared the groups with the highest cardiorespiratory fitness to those with the lowest cardiorespiratory fitness.Overall, a total of 26 studies with over 20.9 million participants from 199 different cohorts were included in the review. Eight of the included studies examined the association between V̇O2 max and death (mortality) from all causes, cardiovascular disease, sudden cardiac events, all cancers, and lung cancer. Compared to low cardiorespiratory fitness, having high cardiorespiratory fitness was associated with a 41% to 53% lower risk for premature mortality. Furthermore, each 1 metabolic equivalent (MET) increase in cardiorespiratory fitness (1 MET is equal to an increase in V̇O2 max of 3.5 mL/kg/min) reduced the risk of premature mortality by 7% (all cancers) to 51% (sudden cardiac mortality).A notable limitation for mortality outcomes was the large disparity in male vs. female participants — more than 1.8 million male participants were included in the studies while only 180,000 females were included.Having a higher cardiorespiratory fitness was also associated with a lower risk of developing hypertension, heart failure, stroke, atrial fibrillation dementia, kidney disease, depression, and type 2 diabetes. Specifically, the risk of a new onset condition was 37% (hypertension) to 69% (heart failure) lower when comparing high vs. low cardiorespiratory fitness.For every 1 MET increase in fitness, the risk of developing a new chronic health condition was reduced by 3% (stroke) to 18% (heart failure).Similar to mortality outcomes, a majority of the evidence was from male populations, although two studies investigated the effects in female-only cohorts. In these groups, high cardiorespiratory fitness was found to be more protective against stroke and type 2 diabetes among females compared to males. Among men, a higher cardiorespiratory fitness was not associated with prostate cancer risk.What about individuals who already have a chronic health condition? Does having a high cardiorespiratory fitness protect them from early death or adverse events?This seems to be the case. A lower risk of premature death or adverse events was observed for people with a higher vs. a lower cardiorespiratory fitness and ranged from 19% (for an adverse event among adults with pulmonary hypertension) to 73% (for cardiovascular mortality among people living with cardiovascular disease).Based on this comprehensive review, not only does having a higher cardiorespiratory fitness reduce the risk of premature death from all causes, but it also reduces the risk of developing a new condition or dying from a condition you already have. Put another way, low fitness is a consistent and important risk factor for early death and chronic disease.If this isn’t enough evidence that cardiorespiratory fitness should be considered a vital sign, I don’t know what is. The authors even suggest that a minimum clinically important difference or MCID for V̇O2 max be established as 1 MET (3.5 mL/kg/min). Exercise trials and other interventions can be deemed “effective” if the participants achieve this degree of fitness improvement. It’s a goal you should strive for in your own exercise regimen.Because this was merely an overview of published literature, we unfortunately don’t have specific numbers for the “high” and “low” V̇O2 max groups. But I did a quick scan of the included studies on mortality risk to find a quick estimate.Low cardiorespiratory fitness is somewhere in the range of less than 8—9.5 METs or a V̇O2 max of less than 28—33 mL/kg/min. High cardiorespiratory fitness is about 11—13.7 METs or more, or a V̇O2 max of 38.5—48. If you’re below or near one of these categories, act accordingly.The certainty (quality) of the evidence was also downgraded mostly due to a large variation in how the studies measured V̇O2 max and the large proportion of male participants. And, of course, the main limitation is that these associations (correlations) may not imply causation. One of the main criticisms of this literature is that, because nearly 50% of one’s V̇O2 max can be explained by genetics and is therefore unmodifiable, the association between cardiorespiratory fitness and healthspan/longevity may not represent an effect of a high fitness level per se, but rather, an underlying predisposition to health. Healthy people have a higher V̇O2 max, but they’re not healthy because of it.I don’t buy this. To explain why, I’ll use the Bradford Hill criteria. The Bradford Hill criteria, also known as Hill’s criteria for causation, are a set of nine principles used to establish epidemiologic evidence of a causal relationship between a presumed cause and an observed effect. These criteria have been widely used in public health research and were proposed by the English epidemiologist Sir Austin Bradford Hill in 1965.The nine criteria are:* Strength (Effect Size)A small association does not rule out causality, but a stronger association increases the likelihood of a causal effect.* Consistency (Reproducibility)Consistent findings across different studies, populations, and settings strengthen the evidence for causality.* SpecificityA specific association between a factor and an effect suggests a higher probability of a causal relationship.* TemporalityThe cause must precede the effect in time* Biological Gradient (Dose-Response Relationship)Generally, greater exposure leads to a higher incidence of the effect.* PlausibilityA plausible mechanism linking cause and effect enhances the evidence.* CoherenceConsistency between epidemiological findings and laboratory evidence strengthens the likelihood of causality.* ExperimentExperimental evidence can support causality.* AnalogySimilarities between the observed association and other known causal relationships can provide additional support.Now, let’s apply the Bradford Hill criteria to V̇O2 max.* Strength of AssociationNumerous studies consistently demonstrate a strong inverse relationship between cardiorespiratory fitness and mortality risk. Case in point: this review.* Consistency of EffectResearch findings consistently support the link between fitness and health outcomes. Multiple studies across diverse populations consistently show that better fitness is associated with improved health and longevity. Again: see this review.* SpecificityWhile cardiorespiratory fitness impacts overall health, it specifically reduces the risk of cardiovascular diseases, diabetes, and certain cancers.* TemporalityThe temporal relationship is well-established: higher fitness precedes better health outcomes. Individuals who maintain or improve their fitness levels over time experience reduced mortality risk.* Dose-Response RelationshipA dose-response pattern exists: as cardiorespiratory fitness increases, mortality risk decreases.* PlausibilityMechanisms underlying this association include improved cardiovascular function, enhanced metabolic health, and reduced inflammation. We know that regular exercise improves heart health, insulin sensitivity, lipid profiles, and overall physiological function.* CoherenceThe association aligns with existing knowledge about exercise physiology and health.* ExperimentAlthough we cannot perform a randomized controlled trial where we randomly assign people to have higher VO2 max, observational studies provide strong evidence.* AnalogyAnalogously, we can draw from other well-established causal relationships. For example, the association between smoking and lung cancer was initially based on observational studies, and later experimental evidence confirmed the causal link.The evidence (and my personal biases) would indicate that improving fitness is a cause of better health. I explain why this may be the case in my book.If you don’t know your V̇O2 max, I provide several methods to estimate V̇O2 max in my book, and for a limited time, I made this chapter open to everyone on my Substack. Feel free to look at some of the protocols and do some testing!Regardless of your current fitness level, take comfort in knowing that improving your V̇O2 max by 1–3 METs (and reducing your risk of death and disease substantially) is very attainable with some dedicated aerobic exercise training.Out of all of the risk factors, V̇O2 max is the one that’s most fun to improve. It might also be the most important.Thanks for reading. I’ll see you next Friday.~Brady~The VO2 Max Essentials eBook is your comprehensive guide to aerobic fitness, how to improve it, and its importance for health, performance, and longevity. Get your copy today and use code SUBSTACK20 at checkout for a 20% discount. You can also grab the Kindle eBook, paperback, or hardcover version on Amazon.Examine.com: Examine is the largest database of nutrition and supplement information on the internet. This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.physiologicallyspeaking.com/subscribe
    --------  
    12:09

Mais podcasts de Saúde e fitness

Sobre Physiologically Speaking

Site de podcast

Ouça Physiologically Speaking, Despertar Zen e muitos outros podcasts de todo o mundo com o aplicativo o radio.net

Obtenha o aplicativo gratuito radio.net

  • Guardar rádios e podcasts favoritos
  • Transmissão via Wi-Fi ou Bluetooth
  • Carplay & Android Audo compatìvel
  • E ainda mais funções
Radio
Aplicações
Social
v6.30.1 | © 2007-2024 radio.de GmbH
Generated: 12/8/2024 - 2:14:47 AM