Healio Rheuminations

In this episode of Rheuminations, host Adam Brown, MD, discusses the history and long line of discoveries that led to non-radiographic axial spondyloarthritis imaging and how that may or may not have helped diagnosis.  
·       Starting with classification criteria. 3:25
·       Trying to understand ankylosing spondylitis 7:40
·       Trouble with X-rays and diagnosis: A lack of radiographic evidence. 14:26
·       How did MRI make a difference? 23:55
·       A longitudinal study. 30:45
·       NSAIDs roll out. 33:12
·       Biologics help us classify non-radiographic axial SpA. 34:14
·       Imaging as a necessity to diagnose. 37:52
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Ahlström H, et al. Arthritis Rheum. 1990;doi:10.1002/art.1780331202
Bollow M, et al. Radiology. 1995;doi:10.1148/radiology.194.2.7824736
Khan M A, et al. Arthritis Rheum. 1985;doi:10.1002/art.1780280107
Murphey M D, et al. Radiology. 1991;doi:10.1148/radiology.180.1.2052702
Oostveen J, et al. J Rheumatol. 1999; 26(9):1953-8.
Prakash S, et al. Ann Rheum Dis. 1983;doi:10.1136/ard.42.6.640
Rudwaleit M, et al. Ann Rheum Dis. 2004;doi:10.1136/ard.2003.011247
Rudwaleit M, et al. Ann Rheum Dis. 2009;doi:10.1136/ard.2009.108233

In this episode of Rheuminations, host Adam J. Brown, MD, untangles the confusing serologies of lupus by learning about their discoveries from the beginning. He answers questions like what's the deal with immunofluorescence patterns, why does SSA/SSB have two names (Ro/LA), and is double-stranded DNA antibody really attracted to both strands?
·       The story of antibodies in lupus. 3:27
·       The "LE" factor. 10:11
·       The changing fluorescent patterns of the staining of the nucleus/ENAs. 18:50
·       The anti-Smith antibody. 24:51
·       The mysteries of SSA and SSB. 28:52
·       Double-stranded DNA. 36:32
·       Crithidia luciliae. 40:30 
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Aarden LA, et al. Ann NY Acad Sci. 1975;doi:10.1111/j.1749-6632.1975.tb29197.x
Alspaugh MA, et al. Arthritis Rheum. 1976;doi:10.1002/art.1780190214
Aslpaugh MA, et al. J Clin Invest. 1975;doi:10.1172/JCI108007
Arana R, et al. J Clin Invest. 1967;doi:10.1172/JCI105677
Clark G, et al. J Immunol. 1969;PMED:4179557
Dubois EL, et al. Blood. 1957;doi:10.1182/blood.V12.7.657.657
Friou GJ, et al. J Immunol. 1958;doi:10.4049/jimmunol.80.4.324
Hargraves MM. Proc Staff Meet Mayo Clin. 1949;doi:10.1016/S0025-6196(25)08519-2
Haserick JR, et al. Am J Med Sci. 1950;doi:10.1097/00000441-195006000-00010
Rowell NR, et al. Arch Dermatol. 1963;doi:10.1001/archderm.1963.01590200064012
Tan EM, et al. J Clin Invest. 1966;doi:10.1172/JCI105479
Tsokos GC. J Immunol. 2006;doi:10.4049/jimmunol.176.3.1295

In this episode of Rheuminations, guest host Leonard H. Calabrese, DO, sits down with David Chernoff, MD, chief medical officer of SetPoint Medical, to discuss the vagus nerve and recent developments in immune mediated disease.
·       The story of Kevin Tracey, MD. 5:08
·       Going from cytokines to the vagus nerve to immune mediated inflammatory disease. 7:23
·       The ups and downs of non-surgically implanted devices. 13:28
·       The pivotal studies. 15:35
·       Gadolinium MRI. 24:03
·       The gut-brain immune axis. 29:35
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Leonard H. Calabrese, DO, can be reached at CALABRL@ccf.org. Follow him @LCalabreseDO.

In this episode of Rheuminations, host Adam J. Brown, MD, will walk you through the history of pleural effusions in rheumatoid arthritis. He discusses topics ranging from fascinating case studies to how pleural effusions are treated today. 
·        Diving into pleural effusions. 2:38
·        What's in the fluid? 12:01
·        When did pleural effusions become linked to RA? 15:18
·        The glucose talk. 27:04
·        Green effusions. 32:40
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

Not all jaw claudication is giant cell arteritis. Hear some interesting cases and learn about things to look for in the labs to suspect an alternative diagnosis along with co-host Leonard H. Calabrese, DO.
·        When GCA isn't GCA, walking through mimic cases 2:43
·        Infectious mimics 14:36
·        Large vessel involvement cases 16:47
·        GCA as a medical emergency 22:05
·        Erdheim-Chester disease 23:40
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.