Talk Python To Me

You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it.

Episode sponsors

Six Feet Up

Talk Python Courses

Links from the show

Guest

Sumit Gundawar: linkedin.com

Course transcripts announcement: talkpython.fm/blog

Sumit Gundawar - JAX London Speaker: jaxlondon.com

Anthropic: anthropic.com

OpenAI Platform: platform.openai.com

Anthropic: anthropic.com

LangChain: langchain.com

OWASP: owasp.org

Pydantic: pydantic.dev

EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu

HIPAA - HHS: www.hhs.gov

NHS: www.nhs.uk

Llama: llama.com

Qwen - QwenLM on GitHub: github.com

OpenAI Platform: platform.openai.com

Hugging Face: huggingface.co

Llama: llama.com

Granola: www.granola.ai

HIPAA - HHS: www.hhs.gov

CodeRabbit: www.coderabbit.ai

Cursor Origin: cursor.com

GitHub Status: www.githubstatus.com

Midjourney Medical: www.midjourney.com

Neko Health: www.nekohealth.com

CERN: home.cern

ATLAS Experiment: atlas.cern

Watch this episode on YouTube: youtube.com

Episode #554 deep-dive: talkpython.fm/554

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Python in Production

Talk Python Courses

Links from the show

@calvinhp@sixfeetup.social: sixfeetup.social

@calvinhp.com: bsky.app

calvinhp.com: calvinhp.com

Original airing on Python Bytes: pythonbytes.fm

pi: pi.dev

superpowers: github.com

Warp.dev: Warp.dev

OhMyZSH: ohmyz.sh

Commandbookapp.com: Commandbookapp.com

Blink: blink.sh

kitty: sw.kovidgoyal.net

mosh: mosh.org

tmux: github.com

Claude code: www.anthropic.com

Claude.md: Claude.md

MacWhisper: goodsnooze.gumroad.com

Handy: handy.computer

Tailscale: tailscale.com

Talk Python episode with Alex: talkpython.fm

Telescopo: www.telescopo.app

Typora markdown: typora.io

formal documentation for many of my open source packages: mkennedy.codes

Great Docs: posit-dev.github.io

Statement on the US government directive to suspend access to Fable 5 and Mythos 5: www.anthropic.com

No second date: x.com

Watch this episode on YouTube: youtube.com

Episode #553 deep-dive: talkpython.fm/553

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show

Guest

Charlie Marsh: github.com

The announcement: astral.sh

OpenAI: openai.com

uv: github.com

ty: github.com

Ruff: github.com

pyx: astral.sh

Codex team: openai.com

Anthropic did something similar by acquiring Bun: www.anthropic.com

Daily Stars Explorer: emanuelef.github.io

Agentic AI Programming for Python: training.talkpython.fm

Python Web Security: OWASP Top 10 with Agentic AI: training.talkpython.fm

Episode #552 deep-dive: talkpython.fm/552

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

Episode sponsors

AgentField AI

Talk Python Courses

Links from the show

Guests

Naunidh Bhalla: linkedin.com

Grant Gittes: linkedin.com

Marcel Kornacker: linkedin.com

Beon de Nood: linkedin.com

Chinmaya Joshi: linkedin.com

David Mytton: linkedin.com

Shea Tate-Di Donna: linkedin.com

Jason Rowley: linkedin.com

Azul Garza: github.com

Renée Rosillo: linkedin.com

Tetrix: tetrix.co

Tetrix Jobs: tetrix.co

Arcjet: arcjet.com

Pixeltable: pixeltable.com

Phemeral.dev: phemeral.dev

CapiscIO: capisc.io

Episode #551 deep-dive: talkpython.fm/551

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please review this for me."



Over the past year, GitHub activity has spiked roughly twelve times in a few short months, and a huge chunk of that signal is landing on the same small group of maintainers who were already stretched thin. The curl bug bounty got buried under AI-generated noise. Jazzband, the home of Django classics like pip-tools and the Django debug toolbar, hit what its maintainer called an "apocalypse" and started sunsetting. Even CPython just shipped fresh guidelines on AI-assisted contributions this week.



So what does all of this actually look like from the receiving end of the pull request?



On this episode, Paolo Melchiorre joins us to tell that story from inside the maintainer's chair. Paolo is a director of the Django Software Foundation, an organizer of PyCon Italy, a Django Girls coach, and he has spent the past year carefully collecting examples of how AI is reshaping open source contributions. The good, the bad, and the extra fingers.



We dig into his PyCon US talk on AI-assisted contributions and maintainer load, why AI is best understood as an amplifier rather than a new kind of contributor, the wildly different policies across 86 open source foundations, whether projects banning AI today are reacting to last year's models.

Episode sponsors

AgentField AI

Talk Python Courses

Links from the show

Guest

Paolo Melchiorre: github.com

DSF: www.djangoproject.com

djangonaut-space: djangonaut.space

PyCon Italia: 2026.pycon.it

uDjango: github.com

My PyCon US 2026 post: www.paulox.net

AI-Assisted Contributions and Maintainer Load: www.paulox.net

Senior Engineer Tries Vibe Coding: www.youtube.com

Code Rabbit AI PR Reviews: www.coderabbit.ai

GitHub Usage Graphs: github.blog

Update on CPython's AI Policies: fosstodon.org

High-Quality Chaos from Curl: daniel.haxx.se

The Generative AI Policy Landscape in Open Source: redmonk.com

Watch this episode on YouTube: youtube.com

Episode #550 deep-dive: talkpython.fm/550

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy