The a16z Show

As part of our summer replay series, we're revisiting one of our favorite conversations from the past year.

Mark Zuckerberg and Dr. Priscilla Chan join Ben Horowitz, Vineeta Agarwala, and Erik Torenberg to discuss the Chan Zuckerberg Initiative's ambitious effort to help cure, prevent, and manage disease by the end of the century.

Rather than funding individual breakthroughs, CZI is focused on building the tools and infrastructure that can accelerate scientific discovery across entire fields. The conversation explores Biohub, Cell Atlas, virtual cell models, open biological datasets, and the growing role of AI in helping researchers better understand human biology.

They discuss why biology still lacks a "periodic table of elements," how AI could help scientists test hypotheses before running expensive experiments, and why pairing frontier biology with frontier AI may unlock a new era of medical discovery.

 

Resources:

Follow Mark Zuckerberg on X: https://x.com/finkd

Follow Dr. Priscilla Chan on Instagram: https://www.instagram.com/priscillachan

Follow Ben Horowitz on X: https://x.com/bhorowitz

Follow Vineeta Agarwala on X: https://x.com/vintweeta

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Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Adam Neumann joins Marc Andreessen, Ben Horowitz, and Erik Torenberg for a candid conversation about entrepreneurship, failure, and building Flow.

Neumann reflects on his childhood, military service, immigration to the United States, the rise and fall of WeWork, and what he learned from one of the most scrutinized founder journeys in technology. He explains why Flow is focused on rethinking housing, community, and belonging, and why he believes technology can fundamentally improve how people live.

The conversation explores resilience, company building, leadership, real estate, software, flexible living, and the global housing crisis. Along the way, Neumann discusses rebuilding trust, designing for community, and why some of the biggest entrepreneurial opportunities emerge from deeply personal experiences.

 

Resources:

Read Marc's blog post about Flow: https://a16z.com/announcement/flow/

Marc on X: https://x.com/pmarca 

Marc’s Substack: https://pmarca.substack.com/ 

Ben on X: https://x.com/bhorowitz 

Erik on X: https://x.com/eriktorenberg 

Erik's Substack: https://eriktorenberg.substack.com/

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Find a16z on YouTube: YouTube
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the primary users of software instead of humans?

The conversation explores the rise of "headless" software, why APIs and agentic workflows are reshaping enterprise applications, and whether traditional SaaS products are becoming systems of record rather than systems of engagement. They discuss Salesforce's Headless 360 announcement, MCP, enterprise software architecture, and why AI may fundamentally change how businesses interact with their data.

Along the way, they examine what actually makes enterprise software sticky, why replacing systems like SAP and Salesforce is harder than it appears, and where startups have the greatest opportunity as AI reshapes the software stack.

 

Resources:

Follow Seema Amble on X: https://x.com/seema_amble

Follow Steven Sinofsky on X: https://x.com/stevesi

Follow Elena Burger on X: https://x.com/VirtualElena

Related Reading

Is Software Losing Its Head?
https://a16z.com/is-software-losing-its-head/

The Death of Software? Nah.
https://a16z.com/death-of-software-nah/

Stay Updated:
Find a16z on YouTube: YouTube
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates.

Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from his own time at Columbia, the founding of technology companies, and investments in startups like Airbnb, he explores the importance of independent thinking, conviction, and pursuing ideas that others may initially dismiss.

Along the way, Horowitz discusses technological progress, entrepreneurship, opportunity, and why he believes today's graduates are entering a world defined less by unprecedented challenges than by unprecedented possibilities.

ee

Resources:

Follow Ben Horowitz on X: https://x.com/bhorowitz

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Find a16z on YouTube: YouTube
Find a16z on X
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Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Ben Horowitz is joined by Anne Neuberger, Raghu Raghuram, and Jen Kha to discuss a16z's expanding international strategy and the growing role technology plays in economic growth, national security, and global partnerships.

The conversation explores why America's technology leadership matters beyond Silicon Valley, how AI is reshaping relationships between governments and the private sector, and why countries around the world are looking to adopt frontier technologies while building stronger innovation ecosystems of their own.

They discuss AI infrastructure, cybersecurity, defense technology, startup expansion, and what it takes to build enduring technology ecosystems. Along the way, they examine the role of trusted partnerships, the importance of Western technology, and why helping founders expand globally has become an increasingly important part of company building.

 

Resources:

Read more about a16z’s global mission:  https://a16z.com/a16zs-global-mission/

Follow Ben on X: https://x.com/bhorowitz

Follow Anne on X: https://x.com/AnneNeuberger

Follow Raghu on X: https://x.com/RaghuRaghuram

Follow Jen Kha on X: https://x.com/jkhamehl

Stay Updated:
Find a16z on YouTube: YouTube
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.