Covering an interesting but ultimately disappointing post hoc study of multiple upadacitinib trials in RA. Initially some hope for clarity in the "Do JAKs cause all the badness?" questions, but ultimately landing me about where I have been since ORAL-SURVEILLANCE was published
Paper: https://www.sciencedirect.com/science/article/pii/S0003496724423091
--------
14:34
--------
14:34
E125: Adrenal Insufficiency after Stopping Prednisone
Interesting read this week - I cover a nifty little paper that presented data about adrenal insufficiency after stopping prednisolone, published in JAMA Open in March 2025.
Open Access Journal Here: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831668
--------
17:52
--------
17:52
e124: MTX vs Pred for Pulmonary Sarcoidosis: PREDMETH Study
Interesting NEJM trial this week comparing methotrexate to prednisone for pulmonary sarcoidosis.
Paper available here: https://www.nejm.org/doi/full/10.1056/NEJMoa2501443
--------
14:18
--------
14:18
E123: Upadacitinib for Giant Cell Arteritis: SELECT-GCA
Podcast this week about the recently published SELECT-GCA study, which evaluated the use of the janus kinase inhibitor upadacitinib (Rinvoq) for patients with new and relapsing GCA. Successful trial and an interesting topic. Paper itself here: https://www.nejm.org/doi/full/10.1056/NEJMoa2413449
--------
18:13
--------
18:13
E122: Guidelines for Maybe Diagnosing HLH
This week I cover another of my newsletters, though I mostly use it as a skeleton to riff on a common (and challenging) issue for rheumatology consultants; diagnosing HLH. Check out the guidelines themselves here and have a listen to the podcast!
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(23)00273-4/fulltext
Brasil