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After months of planning, the US and Israel struck Iran as part of a massive operation aimed at unseating the hardline Iranian regime. Supreme Leader Ayatollah Ali Khamenei was killed in the strikes, according to Israeli sources. Iran has retaliated, hitting US military bases and major population centers across the region. So how long will the conflict last? And is regime change even feasible? We break down what we know as of Saturday afternoon. 

For more: Trump launches the regime-change effort in Iran that he pledged to avoid 

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Guest: Natasha Bertrand, CNN Correspondent 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin

Photo: AP
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The killing of Mexican cartel boss Nemesio “El Mencho” Oseguera Cervantes shocked the country and set off cartel violence in the streets, trapping American tourists in the process. However, experts say the operation could say even more about President Donald Trump’s war on drugs than Mexico’s. 

For more: The death of ‘El Mencho’ exposed the reach of Mexico’s cartel crisis. Will US tourists stay away? 

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Guest: Steven Dudley, InSight Crime co-founder 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin

Photo: @morelifediares via REUTERS
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Victims of Jeffrey Epstein say the historic arrest of Andrew Mountbatten-Windsor, the brother of King Charles III, is a step in the right direction. But high-profile figures in the US still have not faced similar consequences, weeks after the Justice Department released more than 3 million documents related to the late financier and convicted sex offender. We hear from a group of survivors who say this feels like the beginning of the story, not the end. 

For more: ‘This is not over.’ Corporate America’s Epstein reckoning gathers steam 

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Guest: MJ Lee, CNN Senior National Enterprise Correspondent 

Host: David Rind 

Producer: Paola Ortiz 

Senior Producer: Faiz Jamil 

Showrunner: Felicia Patinkin 

Editorial Support: Nicky Robertson

Photo: Kent Nishimura/Reuters
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A raft of resignations from some of Silicon Valley’s top AI companies came with some dire warnings about user safety and potential impacts on the American workforce. Are these concerns worth paying attention to, or overhyped? We hear from one former safety researcher who says companies are not fully grappling with the implications of advertising within chatbots. 

For more: AI researchers are sounding the alarm on their way out the door 

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Guest: Zoë Hitzig, former OpenAI researcher 

Host: David Rind 

Producer: Paola Ortiz 

Senior Producer: Faiz Jamil 

Showrunner: Felicia Patinkin 

Editorial Support: Hadas Gold

Photo: Andrew Harnik/Getty Images
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"I am trying every breath that I have so that I can get you what you need." Those words from ICE attorney Julie Le to a federal judge earlier this month underscores the toll the Trump administration’s immigration enforcement crackdown in Minneapolis is taking on the Justice Department. But what happens now that the surge is winding down? And will any new prosecutors want to sign up for this work? 

For more: Trump’s immigration approach is gumming up the courts, frustrating his Justice Department and judges 

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Guest: Doug Kelley, former Assistant US Attorney 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin 

Editorial Support: Katelyn Polantz

Photo: Steve Karnowski/AP
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