Manifold

Beff Jezos (Guillaume Verdon) is a Canadian physicist, quantum computing researcher, and tech entrepreneur. He is best known as the founder of the Effective Accelerationism (e/acc) movement.

This interview was recorded in collaboration with John Greer and Lei Huang for the documentary film Machine God.

John Greer: https://www.johncgreer.com/

Chapter Markers:

(00:00) - Meet Beff Jezos

(01:56) - Hyperstition vs AI Doom

(21:29) - Accelerate or Die

(37:51) - Scaling Intelligence Upside

(40:26) - Doomers Power Centralization

(47:17) - EAC Physics Framework

(01:10:10) - Debating Doom Narratives

(01:16:13) - Beff Jezos Origin Story

(01:28:06) - Pause Debate and Rapid Fire

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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve.

Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. 

Mechanize is hiring! 
https://mechanize.work/b/hsu 

Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. 

For example: 

Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary 

Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary 

Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

This episode was recorded live at Manifest 2026. Razib Khan is a prominent writer, population geneticist, and podcaster. He is best known for his extensive deep-dives into human evolutionary history, consumer genomics, culture, and ancient DNA. 
https://x.com/razibkhan
https://x.com/razibkhan?lang=en
Chapter Markers:

(00:00) - Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia

(01:18) - Manifest Q&A Kickoff

(02:43) - Yamnaya: Ancient DNA Mysteries

(15:01) - Yamnaya: Y Chromosome Conquests

(22:10) - Embryo Screening and AI

(42:15) - Conformity and Tenure

(46:34) - Academia: Reforms

(53:55) - Academia: Ideological Capture and Funding

(58:19) - Controversies and Closing Q&A

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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve.

Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. 

Mechanize is hiring! 
https://mechanize.work/b/hsu 

Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. 

For example: 

Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary 

Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary 

Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

This special episode was recorded at Tsinghua University in Beijing, generally regarded as the top university in China. Our guests are 3 Americans studying and working at Tsinghua: Gabriel (undergrad), Justin (PhD student in AI), and Alex (Professor in AI research). Topics discussed include: Tsinghua University and elite human capital, AI in China, US-China competition, and the flow of human capital between the US and China

Han Feizi, columnist at Asia Times and the guest from the previous "Letter from Beijing" episode, is also in the room. Letter from Beijing with Han Feizi: https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72

Chapter Markers:

(00:00) - Welcome to Tsinghua University

(02:47) - Gabriel’s Undergrad Journey

(12:35) - Justin’s PhD

(25:10) - Professor Alex on AI and Rankings

(42:51) - Second Chances and Status Signals

(46:48) - China’s Exam Ladder Explained

(50:20) - Infrastructure and Tech Competition

(01:17:18) - Semiconductors, EUV, and Wrap Up

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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve.

Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. 

Mechanize is hiring! 
https://mechanize.work/b/hsu 

Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. 

For example: 

Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary 

Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary 

Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life Institute and the Centre for the Study of Existential Risk, while making early foundational investments in frontier AI labs like DeepMind andAnthropic.
Chapter Markers:

00:00 Assessing Current AI Risk Levels
03:28 Inside Self-Sustaining AI Scenarios
09:10 The Global AI Race Dynamics
42:25 Explaining the Techno-Capital Flywheel
45:34 Insider Origins of AI Safety
56:06 Race Politics and Public Fear
01:23:12 Pop Culture, Movies, and Fame
01:30:15 Big Questions for Humanity's Future
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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve.

Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. 

Mechanize is hiring! 
https://mechanize.work/b/hsu 

Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. 

For example: 

Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary 

Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary 

Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research on polygenic embryo screening in IVF (including the ImputePGTA method), family-based DNA analysis, missing heritability, and the implications of polygenic scores for traits like education and disease. Alex also discusses his recent battles with cancer.
https://x.com/AlexTISYoung

Chapter Markers:

(00:00) - Alex Young Bio

(06:36) - Biobank Era Genetics

(10:49) - Missing Heritability Debate

(27:18) - Embryo Selection Controversy

(50:32) - Embryo Selection Backlash

(53:42) - Mexico City Admixture Study

(01:00:13) - Censorship Via Data Access Control

(01:05:02) - Battle With Cancer and Circulating Tumor DNA (ctDNA)

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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve.

Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. 

Mechanize is hiring! 
https://mechanize.work/b/hsu 

Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. 

For example: 

Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary 

Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary 

Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.