Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

• Ep. 528 The Hidden Power of Menopause – How to Rewire Your Brain & Thrive After 40 |Menopause with Dr. Mindy Pelz

  Today, I am delighted to reconnect with my friend and colleague, Dr. Mindy Peltz, a New York Times bestselling author and a leading voice in women's health, hormones, and aging. She has written several books, with her most recent being Age Like A Girl. She also has a top-ranking podcast and YouTube channel.  In our conversation today, we’ll explain how you can reframe menopause as an evolutionary upgrade. We dive into the neurochemical shifts that occur in menopause, exploring Carol Gilligan's work, the purpose of menopause, the influence of the Gen X generation, and how trauma influences our perimenopause and menopause experiences. We unpack the role of oxytocin, clarify why clutter is problematic, and discuss the effects of environmental psychology. We also highlight the critical importance of bioindividuality at this stage of life, and Dr. Mindy shares the books she likes and recommends. This discussion with Dr. Mindy is personal and deeply philosophical, inviting you to contemplate ideas that will continue to resonate with you long after it ends. IN THIS EPISODE, YOU WILL LEARN: How setting boundaries improves relationships and preserves energy in midlife Why children transitioning to adulthood must be allowed to handle responsibilities How parental over-involvement can hinder the independence of young adults How the neurochemical shifts in perimenopause and menopause alter women’s emotional responses and priorities The value of novelty and new experiences for supporting mental and emotional health How clutter impacts stress levels, especially during hormonal changes The benefits of creating calm environments to regulate the brain and emotional system How downsizing can bring profound peace and freedom Why solitude and personal space are essential for self-regulation in midlife How menopause creates the need for recalibrating relationship boundaries Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Mindy Pelz On⁠ YouTube⁠ ⁠Age Like A Girl (Website)⁠ ⁠Pre-order a copy of Age Like A Girl

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• Ep. 527 Ep. 527 HRT Changes Your Lipids More Than You Think – The Surprising Truth About Menopause & Heart Disease with Dr. Thomas Dayspring |Women's Cardiovascular Health

  I am honored to have Dr. Tom Dayspring join me again today for another AMA session. He and I have done eight podcasts before, and this is a continuation of our last Ask Me Anything episode.  Dr Dayspring is an esteemed expert on internal medicine and clinical lipidology. He is likely one of the most influential worldwide lipid experts, so I am thrilled to have him back with me to dive into various topics related to listener questions, including the impact of hormone replacement therapy on lipid changes, methods of administration, and why bioidentical hormone replacement therapy is preferable for managing both menopausal symptoms and lipid health. We discuss medications, including PCSK9 inhibitors and GLP-1s, as well as intermittent fasting, lipids, and cardiovascular disease risk. We also examine how heart disease develops gradually, over time, the impact of stress and lifestyle, and Dr. Dayspring shares the labs he recommends beyond traditional lipids, ApoB, and LpA. In our discussion, Dr. Dayspring noted that he was not in a position to speak about GLP-1 therapies or microdosing. Since I received many questions from listeners on those topics, I will host a future solo AMA to address some of their concerns. Today's conversation with Dr. Tom Dayspring is truly invaluable, and I trust you will walk away with valuable insights you can share with your healthcare providers. We created a PDF - cynthiathurlow.com/lipids -  specifically for listeners that outlines key labs to discuss with your providers and questions to ask them to help you advocate for your own health and your family members' health. IN THIS EPISODE, YOU WILL LEARN: Why being physically fit does not always eliminate the risk of heart problems arising How ApoB and cholesterol contribute to heart disease over decades Why the early testing of risk factors is essential How chronic stress increases the risk of heart disease  How high cortisol affects insulin sensitivity and glucose regulation How stress impacts endothelial and nitric oxide function The link between low Omega-3 levels and heart problems How insulin resistance degrades heart health How high homocysteine levels can impair endothelial function and contribute to cardiovascular problems Connect with Cynthia Thurlow   Follow on⁠ X⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia’s⁠ website⁠ Submit your questions to [email protected] Join other like-minded women in a supportive, nurturing community ⁠(The Midlife Pause/Cynthia Thurlow⁠)⁠ ⁠ Cynthia’s⁠ Menopause Gut Book⁠ is on presale now! Cynthia’s⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Thomas Dayspring On X (@DrLipid) On LinkedIn

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• BONUS: Are You Deficient in C15:0? – The Fastest Way to Improve Sleep, Mood & Metabolic Health with Dr. Stephanie Venn-Watson

  We have another episode in a series of discussions with well-vetted guests from companies that I feel my community would benefit from hearing about Today, I speak with Dr. Stephanie Venn Watson, a veterinary epidemiologist and the co-founder and co-CEO of Serafina Therapeutics. She has worked with the World Health Organization, DARPA, and the US Navy. She has over 70 patents and has authored more than 80 peer-reviewed scientific papers, and her discoveries have featured on NPR, Science Friday, BBC, NBC, and National Geographic. Her groundbreaking discoveries around the health benefits of C15:0 are the topic of a recent book. In our conversation today, we explore longevity molecules and geno-protective molecules, why they matter, and how they work. We cover the basics of rapamycin and glucophage, then dig into the growing body of research on longevity and lifespan, specifically looking at C15:0, what it is, what it does, why it’s important, and how it’s the first essential fatty acid discovered in decades. We look at its wide-ranging pleiotropic effects on metabolic health, mood, sleep, the brain, gut, and immunity, as well as the signs of low C15:0 levels and the specific labs that can identify a deficiency. We also talk about the benefits of supplementation and improved bioavailability.  Since I have been taking C15:0 myself over the last four to five months and noticed improvements in my recovery and sleep, I’m excited to share this informative and helpful conversation, humbly dedicated to the essential saturated fatty acid, C15:0. IN THIS EPISODE, YOU WILL LEARN: • The role C15:0 plays in guiding the aging process and new findings about its benefits for the immune  system, brain, and longevity • C15:0’s emerging importance as a key player in metabolic balance • What Dr. Venn-Watson’s animal studies revealed about the mechanisms of aging in humans • Why women in midlife become more vulnerable to shifts in immune quality and cellular resilience • The ways nutritional deficiencies can appear in blood markers long before symptoms develop • What occurs with red blood cell stability and aging markers when C15:0 levels are too low • Which biomarkers are now being considered early indicators of biological aging • Formulation features of C15:0 that enhance its bioavailability • The multiple bodily systems that can benefit from supplementing with C15:0 Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠[email protected]⁠ Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow) ⁠https://www.facebook.com/groups/themidlifepause⁠ Cynthia’s ⁠Menopause Gut Book ⁠is on presale now! Cynthia’s ⁠Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ ⁠Fatty 15⁠ Connect with Dr. Stephanie Venn-Watson ⁠Fatty 15⁠ ⁠Discover C15:0⁠ ⁠Seraphina Therapeutics⁠ ⁠LinkedIn⁠⁠ ⁠

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• Ep. 526 Build Muscle, Burn Fat, Fix Your Microbiome – The Ultimate Blueprint for Healthy Body Composition with Dr. William Davis

  Today, I am delighted to welcome Dr. William Davis, a cardiologist and New York Times bestselling author of the Wheat Belly series. He is also the author of Undoctored, Super Gut, and his latest book, Super Body. In our conversation, we dive into the toxic diet industry and how it profits from repeatedly delivering wrong messages. We explore physiological changes in body composition that contribute to poor metabolic health and inflammation, the dangers of ectopic fat, and the influence of our environment. Dr. Davis explains the weight loss Ponzi scheme and how muscle loss drives changes in body composition. We also unpack the gut-muscle axis, the role of the microbiome in muscle building, SIBO and treatment options, and examine the broader effects of oxytocin on body composition, touching on the benefits of replacing lost biological compounds, like collagen and hyaluronic acid, the impact of Max, the microbiota, and accessible carbs, along with practical takeaways to support healthier living and better body composition. This conversation with Dr. Will Davis is incredibly insightful, and I look forward to having him back to discuss the female and vaginal microbiomes. IN THIS EPISODE, YOU WILL LEARN: The specific probiotic strain that influenced body composition in a clinical trial The benefits of fiber for your metabolism and fat distribution The role of collagen and hyaluronic acid in joint, skin, and vascular health How animal-based fibers affect the microbiome differently from plant fibers The value of fermented foods for cultivating beneficial gut microbes The long-term risks of restrictive diets  How declining estrogen alters immune function in women The lasting impact of antibiotics and past treatments on gut microbiota How to prepare your gut for a thriving microbial ecosystem The surprising effects of foundational probiotic interventions on mood and social behavior Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. William Davis On his website  YouTube Blog Defiant Health (Podcast) Books

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• Ep. 525 We’ve Been Misled About Metabolic Health – The Shocking Truth About Cholesterol, GLP-1 & Aging with Dr. Nick Norwitz

  I am thrilled to reconnect with Nick Norwitz today. Nick is a researcher and educator with a mission to make metabolic health a mainstream concern. He graduated valedictorian from Dartmouth College, completed his PhD in metabolism at the University of Oxford, and earned his MD at Harvard Medical School. He has become known as a clinical researcher and metabolic health educator, speaking and writing on various topics, including brain health, microbiome, mitochondrial function, cholesterol, and more.  In our conversation, we discuss the challenges of providing evidence-based medicine, and Nick shares his personal story of overcoming inflammatory bowel disease with a ketogenic diet. We explore the research on statins reducing endogenous GLP-1 production, highlighting the importance of staying curious. We also clarify the different types of type 2 diabetes, the effects of biomolecular aging, and different perspectives on Lp(a).  Nick always provides thoughtful and valuable insights on a range of topics. His Substack is one of my favorites, sharing several ways to enhance your learning process, as a clinician or a layperson. IN THIS EPISODE, YOU WILL LEARN: How his struggle with inflammatory bowel disease led Nick to realize that the evidence-based care of western medicine is not always the best type of care, and how a ketogenic diet saved his life How a recent study highlighted several major physical issues statins cause, yet it went largely unnoticed in medicine and the media The need for clinicians to inform their patients about the potential side effects of their medications How physicians tend to ignore evidence in favor of one-sided messaging that erodes trust and undermines informed care The importance of remaining curious and acknowledging that what you learned initially might be incorrect How technological advances will make personalized medicine the future of healthcare The limitations of traditional one-size-fits-all randomized controlled trials The sub-phenotypes of type 2 diabetes How enzyme inhibitors (like statins) disrupt the gut microbiome How metabolic health and oxidative stress affect Lp(a), and how vitamin C can potentially reduce its impact Bio: Nick Norwitz Nick Norwitz, MD, PhD, is a researcher-educator whose mission is to “Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry, before completing his PhD in Metabolism at the University of Oxford and his MD at Harvard Medical School.  Nick has made a name for himself as a clinical research and metabolic health educator, speaking and writing on topics ranging from brain health, the microbiome, and mental health to muscle physiology, mitochondrial function, and cholesterol and lipids. His mantra is “Stay Curious.” Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Nick Norwitz On YouTube, X, and Instagram His Substack

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