PodcastsCiênciaEveryday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Everyday Wellness™
Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+
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  • Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

    Ep. 614 "The Progesterone Conversation We've Been Missing" | Menopause, Perimenopause, Progesterone

    02/07/2026 | 32min
    Welcome to this week’s Midlife Minute.

    In this episode, we’re focusing on progesterone, exploring the differences between progesterone and progestins, how progesterone is used in clinical practice, and how individual responses can vary significantly.

    IN THIS EPISODE, YOU WILL LEARN:


    Why bioidentical progesterone and synthetic progestins are not interchangeable


    How early synthetic progestin studies continue to shape how progesterone is viewed


    How different routes of progesterone administration produce different effects 


    Why do some women experience stronger neurological or physical effects than others on the same progesterone dose


    How cyclical versus continuous use can affect how progesterone is used in the body 


    Why some women experience sleep or mood changes on oral progesterone


    The importance of personalized decision-making

    Connect with Cynthia Thurlow  


    Follow on X, Instagram & LinkedIn


    Check out Cynthia’s website.


    Submit your questions to support@cynthiathurlow.com 


    Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 


    Purchase Cynthia’s book, The Menopause Gut.


    Cynthia’s Intermittent Fasting Transformation Book


    The Midlife Pause Supplement Line

    Resources: 


    The pharmacodynamics and safety of progesterone doi:10.1016/j.bpobgyn.2020.06.002


    Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone doi:10.1016/0378-5122(93)90064-O


    Pharmacokinetics of progesterone and its metabolites allopregnanolone and pregnanolone after oral administration of low-dose progesterone doi:10.1016/j.maturitas.2005.11.005


    Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women doi:10.1016/j.psyneuen.2019.104465


    Behavior of Male Gamete Fusogen GCS1/HAP2 and the Regulation in Arabidopsis Double Fertilization doi:10.3390/biom13020208


    Tolerance to allopregnanolone with focus on the GABA receptor doi:10.1111/j.1476-5381.2010.01059.x


    Effects of exercise training on the cardiovascular system: pharmacological approaches doi:10.1016/j.pharmthera.2007.03.010


    Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABA modulators doi:10.1016/j.psyneuen.2009.02.003


    Paradoxical effects of GABA modulators may explain sex steroid induced negative mood symptoms in some persons doi:10.1016/j.neuroscience.2011.03.061


    Progesterone selectively increases amygdala reactivity in women doi:10.1038/sj.mp.4002030


    Progesterone and allopregnanolone neuroprotective effects in the central nervous system doi:10.1016/S0006-8993(02)02366-5


    Allopregnanolone and mood disorders doi:10.1016/j.pneurobio.2013.07.005


    GABA receptor plasticity and neurosteroid cell withdrawal during the estrous cycle doi:10.1523/JNEUROSCI.2800-09.2009


    Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study doi:10.1007/s10549-007-9523-x


    Management of Menopausal Symptoms: A Review doi:10.1001/jama.2022.24140


    Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis doi:10.1080/13697137.2018.1467611


    Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women doi:10.1210/jc.2010-2558
  • Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

    Ep. 613 The Role of Peptides in Longevity and Midlife Health with Nathalie Niddam | Menopause, Perimenopause, Peptides

    01/07/2026 | 1h 2min
    Today, I am thrilled to connect with a friend and colleague, Nat Niddam. Nat is a certified holistic nutritionist and epigenetic coach, and host of the Longevity with Nat Niddam podcast. She has one of the most engaged professional and public communities focused on peptide education and longevity protocols.

    In today's discussion, we explain what peptides are and how they differ from HRT. We explore the differences between bioregulators and signaling peptides, clarify how peptides affect neurological and gut health, discuss beneficial peptides for muscle health and longevity, and examine the challenges surrounding peptide hype. We also explain why discernment is essential if you are considering peptides as part of a treatment plan with a licensed medical provider, and highlight specific topical peptides that can be helpful for aging skin.

    I look forward to having Nat back to continue our conversation about peptide therapies. 

    IN THIS EPISODE, YOU WILL LEARN:


    What are peptides?


    How signaling peptides differ from bioregulators


    Why it’s essential to work with a knowledgeable practitioner when considering peptides


    Why sleep, hormones, stress levels, and gut health must be optimized before utilizing peptides


    How peptides can support recovery, muscle maintenance, and heavy training periods


    The importance of finding trustworthy practitioners and being skeptical of claims that sound too good to be true


    Peptide compounds that can help people recover faster between workouts


    Peptides and bioregulators that can support the immune system as we age


    Topical peptides that can support collagen, elastin, wound healing, and skin repair

    Bio:  Nathalie Niddam

    Nathalie Niddam, a holistic nutritionist and longevity educator, is dedicated to helping us all live joyful, vibrant lives well into our 50s, 60s, and beyond.

    She shares strategies—from health tech to ancestral health, to peptides and more on her podcast, Longevity Podcast with Nathalie Niddam.

    She speaks internationally, sharing her deep expertise on bioregulators—leading-edge compounds with the power to awaken the body's innate rejuvenation systems.

    Connect with Cynthia Thurlow  


    Follow on X, Instagram & LinkedIn


    Check out Cynthia’s website.


    Submit your questions to support@cynthiathurlow.com 


    Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 


    Purchase Cynthia’s book, The Menopause Gut.


    Cynthia’s Intermittent Fasting Transformation Book


    The Midlife Pause Supplement Line

    Connect with Nathalie Niddam


    On her website


    Longevity with Nathalie Niddam (Podcast)


    On Instagram
  • Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

    BONUS: Protein, Creatine and Training for Menopause and Beyond with Dr. Stacy Sims

    29/06/2026 | 1h 7min
    I am honored to connect with Dr. Stacy Sims today. She is a forward-thinking international exercise physiologist and nutrition scientist on a mission to revolutionize exercise and nutrition performance- particularly for women.

    In our conversation, we discussed the exclusion of women from research in the modern science era and how gender differences begin in utero. We look into the importance of tracking our menstrual cycles, the differences between follicular and luteal phases, and problematic ovulatory cycles, exploring the current research on oral contraceptives, the impact of the Women's Health Initiative, and the kind of training that is essential for women in perimenopause and menopause. We also cover the physiologic changes that occur in perimenopause and menopause, and Dr. Sims shares her thoughts on weight loss resistance, SECO, undereating, the importance of protein, and essential supplements for middle-aged women.

    I know you will love this invaluable conversation with Dr. Stacy Sims.

    IN THIS EPISODE YOU WILL LEARN:


    Why are women still excluded from many studies?


    How the physiological differences between men and women begin in utero and continue through adulthood


    How stress during pregnancy affects the developing fetus


    How the muscle morphology of women differs from that of men 


    Why girls need to learn new ways to move and build strength during puberty


    How tracking menstrual cycle phases helps women optimize their training


    The potential long-term effects of using oral contraceptives


    Why a diverse diet is essential for supporting gut health


    Common misconceptions surrounding hormone therapy


    Why Dr. Sims recommends creatine for women in perimenopause and menopause

    Connect with Cynthia Thurlow  


    Follow on X, Instagram & LinkedIn


    Check out Cynthia’s website.


    Submit your questions to support@cynthiathurlow.com 


    Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 


    Purchase Cynthia’s book, The Menopause Gut.


    Cynthia’s Intermittent Fasting Transformation Book


    The Midlife Pause Supplement Line

    Connect with Dr. Stacy Sims 


    On her⁠ website⁠


    Instagram⁠


    ⁠Facebook⁠


    ⁠TikTok
  • Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

    Ep. 612 Why Perimenopause Affects More Than Your Cycle with Emily Sadri, NP | Menopause, Perimenopause, Estrogen

    27/06/2026 | 1h 18min
    Today, I am delighted to welcome Emily Sadri, a board-certified women’s health nurse practitioner and certified nurse-midwife, also trained in functional medicine. Emily is the founder of Aurelia Health, a private women’s health practice in the Van Aken district of Shaker Heights, Ohio, offering telehealth services specializing in hormone therapy and weight-loss support for women ages 35 to 55. As a leading hormone expert, she has built her practice around a hormones-first approach.

    In today’s conversation, Emily explains the differences between being a nurse practitioner and a midwife, and we discuss nurse practitioner training, scope of practice, professional support, anticipatory guidance, and the limitations of conventional midlife care. Emily also shares why she prioritizes precision-oriented, personalized care, the value of Mira monitoring for precision hormone replacement therapy management in perimenopause, key hormonal changes she sees in early perimenopause, the impact of cyclic, static, and physiologic dosing of HRT, the influence of progestin IUDs, trends in healthcare, and less common reasons why women in midlife tend to become weight loss resistant.

    Stay tuned for an insightful conversation on hormones, precision care, and supporting women through perimenopause and midlife.

    IN THIS EPISODE, YOU WILL LEARN:


    How women's health nurse practitioner training differs from midwifery, and how midwifery shaped Emily’s professional philosophy and ethics


    Why women need to take ownership of their health throughout every life stage 


    The importance of moving beyond treating symptoms by using comprehensive lab work to identify broader hormonal and metabolic patterns


    The value of using Mira, an at-home hormone monitoring system, to follow hormone patterns throughout an entire menstrual cycle, rather than relying on isolated laboratory measurements


    Why Emily believes in looking at hormone patterns rather than progesterone decline or isolated estrogen levels when making hormone replacement therapy decisions


    How static, cyclic, and physiologic HRT differ, and why Emily believes physiologic dosing deserves greater consideration.


    Why treating hormones in isolation often fails to address the bigger picture, particularly during perimenopause


    The importance of women being fully informed when considering hormonal birth control and intrauterine devices


    Factors beyond sarcopenia, nutrition, sleep, and stress that could contribute to weight loss resistance 

    Bio: Emily Sadri

    Emily Sadri is a Board Certified Women’s Health Nurse Practitioner, Certified Nurse Midwife, and hormone expert who founded Aurelia Health, a modern concierge telehealth company that serves women navigating perimenopause and menopause.

    Emily's areas of expertise include metabolic health, precision hormone care, and longevity medicine. Her mission is to advance comprehensive care in midlife, create a model that fills in the gaps where primary care is failing women, and to recenter care around the relationship AS the medicine.

    She resides in the Midwest with her husband, four children, and two dogs.

    Connect with Cynthia Thurlow  


    Follow on X, Instagram & LinkedIn


    Check out Cynthia’s website.


    Submit your questions to support@cynthiathurlow.com 


    Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 


    Purchase Cynthia’s book, The Menopause Gut.


    Cynthia’s Intermittent Fasting Transformation Book


    The Midlife Pause Supplement Line

    Connect with Emily Sadri


    On her website


    Instagram


    Aurelia Health
  • Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

    Ep. 611 "What the Pill & Depo Do to Your Bones" | Menopause, Perimenopause, Bone Health

    25/06/2026 | 42min
    Welcome to the latest Midlife Minute.

    Today, we’re discussing how oral contraceptives and Depo Provera can impact women’s bone health over time.Stay tuned as I walk you through the research, prescribing trends, and ways women can support their bone health.

    IN THIS EPISODE, YOU WILL LEARN:


    How peak bone mass in adolescence affects bone health later in life


    How oral contraceptives can interfere with the bone development of young women


    The lack of informed conversations about the bone health risks associated with long-term contraceptive use


    Why Depo Provera may have a stronger impact on bone density than oral contraceptives


    The importance of nutrition and strength training for supporting bone health


    How hormonal contraceptives can affect the gut microbiome and immune system


    What you need to consider regarding your bone density and long-term health if you’ve been using oral contraceptives or Depo for many years

    Connect with Cynthia Thurlow  


    Follow on X, Instagram & LinkedIn


    Check out Cynthia’s website.


    Submit your questions to support@cynthiathurlow.com 


    Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 


    Purchase Cynthia’s book, The Menopause Gut.


    Cynthia’s Intermittent Fasting Transformation Book


    The Midlife Pause Supplement Line

    Resources:


    Depot medroxyprogesterone acetate, oral contraceptives and bone mineral density in a cohort of adolescent girls doi:10.1016/j.jadohealth.2004.07.005


    Oral Contraceptive Use and Bone Density Change in Adolescent and Young Adult Women: A Prospective Study of Age, Hormone Dose, and Discontinuation doi:10.1210/jc.2010-3027


    Adolescent use of combined hormonal contraception and peak bone mineral density accrual: A meta-analysis of international prospective controlled studies doi:10.1111/cen.13932


    No need to specialize: reproductive health is for all adolescents doi:10.1016/j.jpag.2006.01.055


    Injectable Hormone Contraception and Bone Density: Results from a Prospective Study doi:10.1097/00001648-200209000-00015


    Hormonal contraception and the development of autoimmunity: A review of the literature doi:10.1080/00243639.2017.1360065


    Oral contraceptives, reproductive factors and risk of inflammatory bowel disease doi:10.1136/gutjnl-2012-302362


    Combined oral contraceptive use and the risk of systemic lupus erythematosus doi:10.1002/art.24398


    Oral Contraceptives and Multiple Sclerosis/Clinically Isolated Syndrome Susceptibility doi:10.1371/journal.pone.0149094


    The Experience of Surviving a High-Risk Pregnancy doi:10.1080/23293691.2016.1166104


    Effects of 0.9 mg Recombinant Human Thyrotropin on Thyroid Size and Function in Normal Subjects: A Randomized, Double-Blind, Cross-Over Trial doi:10.1210/jc.2004-0914
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Sobre Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+
Looking for the latest strategies for dealing with menopause, hormones and midlife health issues? You're in the right place! Cynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author and international speaker, with over 15 million views for her second TEDx talk (Intermittent Fasting: Transformational Technique). With over 25 years experience in health and wellness, Cynthia is a globally recognized expert in perimenopause/menopause and intermittent fasting, and has been featured on ABC, FOX5, KTLA, CW, Medium, Entrepreneur, and The Megyn Kelly Show. Her mission is to help empower women to live their most optimal lives in perimenopause and beyond.
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