Freely Filtered, a NephJC Podcast

The Filtrate
Joel Topf @kidney_boy
Swapnil Hiremath @hswapnil.medsky.social
Natalie Freidin Program director at Medical University of South Carolina
AC @medpeedskidneys.bsky.social
Special Guests
Fernando Fervenza Professor of Medicine, The Mayo Clinic

Editing
Vip Vergues
The Kidney Connection written and performed by Timothy Yau

Show Notes
MENTOR NephJC | NEJM | Freely Filtered episode 7
PLA2r in 2009 M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy NEJM
MAJESTY NephJC | NEJM Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy
Giuseppe Remuzzi discovers rituximab works in primary membranous. Rituximab for idiopathic membranous nephropathy The Lancet 2002
Fervenza’s 15-person study of Rituximab treatment of idiopathic membranous nephropathy Kidney International 2008.
Larry Beck’s NEJM PLA2r study M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy NEJM 2009
2011 (not 2010) JASN paper where using banked serum from two prior rituximab studies in membranous nephropathy, Beck and Fervenza showed that declines in anti-PLA2R antibodies preceded reductions in proteinuria and predicted subsequent clinical remission, establishing the concept that immunologic remission precedes clinical remission. Rituximab-Induced Depletion of Anti-PLA2R Autoantibodies Predicts Response in Membranous Nephropathy PubMed
The National Institute of Animal Health…a Fervenza fiction
Robert A. Star, M.D. NIH
Daniel C. Cattran, M.D. NephCure

Tubular Secretions
Swap do not go to see Mandalorian and Grogu or Supergirl
AC doing nothing
Natalie The Wealth Ladder by Nick Maggiulli (amazon)
Fernando South Portugal and GlomCon Hawaii
Joel The Boundary Waters Canoe Area

The Filtrate
Joel Topf@kidney_boy
Vipin Verghese@vipvargh.bsky.social
Nayan Arora @captainchloride
Special Guests
David Goldfarb Professor of Medicine, NYU (COI)
Megan Prochaska Assistant professor of medicine at University of Chicago
John Asplin Medical Director Consultant LithoLink (Twitter)

Editing
Anna Gaddy
The Kidney Connection written and performed by Timothy Yau

Show Notes
Kidney Treks, University of Chicago. For medical students.
The Push Trial: Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention NephJC Short | The Lancet
Charlie Pak trial showing increased urine volume reduced risk of kidney stones. Evidence justifying a high fluid intake in treatment of nephrolithiasis PubMed
The Borghi Trial: Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study PubMed
Medical Management of Kidney Stones: AUA Guideline (2026)
Weird little trial Asplin mentioned with amlodipine. But it was actually verapami. By Kemal Sarical: The effect of calcium channel blockers on stone regrowth and recurrence after shock wave lithotripsy PubMed
Borghi’s other giant study in kidney stones: Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria NEJM
The No Stone Trial: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence NephJC | NEJM
Gary Curhan epidemiologic data from the Nurses Health Study and the Health Professionals Follow-up Study: Twenty-four-hour urine chemistries and the risk of kidney stones among women and men PubMed
Gary Curhan epidemiologic data on sugar sweetened beverages and risk of kidney stones. Soda and other beverages and the risk of kidney stones PubMed
Eric Topol’s tweet:

NephJC in 2014 on the ACP Kidney Stone Guidelines NephJC
Goldfarb’s scathing editorial on said guidelines, not on NephJC as I said but, on Fred Coe’s website at the University of Chicago. Link
Tubular Secretions
Nayan: Shrinking on Apple TV Wikipedia
David: The deaths of Sonny Rollins (Wikipedia) and James Blood Ulmer (Wikipedia)
Megan: Sri Lanka for travel (National Geographic)
Vipin: Memory Eternal: Living with Grief as Orthodox Christians (Amazon)
John: A History of Rock Music in 500 Songs (Link) Patty Smith’s memoir, Just Kids (Amazon)
Joel: This is How You Lose The War by Amal El-Mohtar and Max Gladstone (Amazon) for the second time, and Acquired PodCast (Link)

The Filtrate
Joel Topf kidneyboy.bsky.social
Swapnil Hiremath @hswapnil.medsky.social
Natalie Freidin Program director at Medical University of South Carolina
Sophia Ambruso @sophia_kidney
AC @medpeedskidneys.bsky.social

Special Guests
Carla Nester, Professor of Medicine, Professor of Pediatrics, University of Iowa. Senior author of Valiant

Editing
Natalie Freidin
The Kidney Connection written and performed by Timothy Yau

Show Notes
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN NEJM | NephJC

Tubular Secretions
Swapnil: City of Last Chances by Adrian Tchaikovsky (Amazon)
Natalie: Heated Rivalry, the books by Rachel Reid
Carla: Rowing and gold fiber embroidery
AC: Audiobooks, that are appropriate for children: The Giver and Tuck Everlasting
Sophia: Greeking Out podcast and the Wheel of Time by Robert Jordan (Wikipedia)
Joel: This is How You Lose The War by Amal El-Mohtar and Max Gladstone (Amazon)

The Filtrate
Joel Topf kidneyboy.bsky.social
Swapnil Hiremath @hswapnil.medsky.social
Pedro Teixeira @nephcrit.bsky.social

Special Guests
Ewout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.
Harish Seethapathy, Assistant physician at Massachusetts General Hospital

Editing
Vipin Verghese
The Kidney Connection written and performed by Timothy Yau

Show Notes
A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJC
Seethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM Evidence
MacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM Evidence
SALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal Medicine
SALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM
Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney International
The Richard Sterns’ article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASN
The European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of Endocrinology
The American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of Medicine
Treating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney International
Prospective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluids
Helbert Rondon’s RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.gov
Tubular Secretions
Swapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)
Harish: Disney Cruise
Edward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)
Pedro: Scrubs reboot (IMDB)
Joel: KIDNEYcon

The Filtrate
Joel Topf kidneyboy.bsky.social

Special Guests
Dr. Samir Parikh, President of the American Society of Nephrology
Prof. Donal Reddan, President, Irish Nephrology Society
Prof. Catherine Godson
Editing
Joel Topf
The Kidney Connection written and performed by Timothy Yau

Show Notes

Tubular Secretions
Joel Topf, the Dublin Port Greenway Link
Catherine Godson: never heard of the Dublin Port Greenway
Samir Parikh: Trinity College Dublin and specifically the Eavan Boland Library, named after the Irish poet.
Donal Reddan: Something about rugby