JNC CardioConnect

This episode of JNC CardioConnect explores a new JNC study showing that ¹²⁴I-evuzamitide PET/CT can detect cardiac involvement in rare amyloidosis subtypes that conventional imaging often misses. Editor-in-Chief, Marcelo Di Carli, MD, MASNC speaks with authors Olivier Clerc, MD, MPH and Sharmila Dorbala, MD, MPH, MASNC about the findings, the limitations of today's bone-tracer-based diagnostic approach, and what Bayer's recently announced positive Phase 3 REVEAL results could mean for a future pan-amyloid diagnostic strategy.

In this special episode of JNC CardioConnect, Editor-in-Chief, Marcelo Di Carli, MD, MASNC is joined by Omar F. Abou Ezzeddine, MD, MS, Prem Soman, MD, PhD, MASNC, Sharmila Dorbala, MD, MPH, MASNC and Ahmad Masri, MD, MS to discuss the rapidly evolving landscape of cardiac amyloidosis — from the biology that explains what we see on imaging, to best practices in cardiac amyloid radionuclide scintigraphy, the promise of amyloid-targeted PET tracers, and the emerging novel therapies. A rich and forward-looking conversation that covers both where the field stands today and where it's headed. Access the full compendium available open access on the JNC website.

Women with heart disease have long been underserved by the very tools designed to diagnose them, but that may be changing. In this episode, Editor-in-Chief, Marcelo Di Carli, MD, MASNC is joined by Stephen Horgan, MB, BCh PhD, FASNC, Jamshid Maddahi, MD, MASNC, and Panithaya Chareonthaitawee, MD, MASNC and break down a landmark sub-study from the Aurora trial showing that F-18 flurpiridaz PET significantly outperforms traditional SPECT imaging in detecting obstructive coronary artery disease in women, with higher accuracy, better image quality, and nearly half the radiation dose. The conversation goes further, exploring how quantifying actual blood flow with PET could unlock diagnoses that have eluded clinicians for years, particularly for the many women whose symptoms stem not from blocked arteries, but from microvascular disease. Read the article.

In this episode, Editor-in-Chief Marcelo F. Di Carli, MD, MASNC leads a timely conversation on the future of cardiovascular imaging training with Ron Blankstein, MD, and Lawrence Phillips, MD, MASNC. The conversation unpacks the new ACC-sponsored advanced imaging training statement and why multimodality competency is essential for nuclear cardiologists seeking to remain clinically relevant in a world of disease-centered imaging.

What if SPECT could bring the promise of myocardial blood flow quantification to every lab on earth?

In this episode, Editor-in-Chief Marcelo Di Carli, MD, MASNC sits down with Yufan Gu, MD and Lei Wang, MD from the Chinese Academy of Medical Sciences, Fuwai Hospital in Beijing, China, and ASNC President Panithaya Chareonthaitawee, MD, MASNC to discuss a novel perfusion radiotracer- 4-BOH- poised to transform SPECT myocardial perfusion imaging. The team traces the journey from teboroxime to 4-BOH, explaining how advances in tracer chemistry and CZT detector technology could make quantitative flow imaging with SPECT accurate, affordable, and globally accessible. You can read the article here: Preclinical and first-in-human studies of a novel tracer for single-photon emission computed tomography myocardial blood flow quantification