Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Can skincare influence healthy aging beyond reducing fine lines and wrinkles?

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald welcomes Carolina Reis Oliveira, PhD, CEO and co-founder of OneSkin, for a science-based discussion on cellular senescence, skin aging, and the connection between skin health and longevity.

Carolina explains the research behind OneSkin's OS-01 peptide, developed after screening more than 900 peptides to identify one that targets senescent ("zombie") cells. These aging cells contribute to inflammation, collagen loss, impaired skin barrier function, and visible skin aging.

Together, they explore the latest research on biological skin age, skin inflammation, barrier repair, collagen production, sensitive skin, retinol, microneedling, hair thinning, scar recovery, and the effects of GLP-1–associated weight loss on skin health. They also discuss why testing complete skincare formulations matters and how longevity science is shaping the future of skincare.

Whether you're a clinician, skincare professional, or simply interested in healthy aging, this episode offers an evidence-informed look at where longevity science and skincare intersect.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Carolina Reis Oliveira* is the CEO and co-founder of OneSkin and a longevity scientist with a Ph.D. in stem cell biology and tissue engineering. Her company develops groundbreaking products to reverse skin aging by targeting senescent cells, one of the central drivers of aging.

THANKS TO OUR SPONSOR

OneSkin: https://www.oneskin.co/

OneSkin is designed to enhance how skin functions, so it stays healthier and more resilient as you age. For a limited time, you can try OneSkin for 15% off with code DRKF a http://oneskin.co/DRKF

CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Hormones are about far more than hot flashes.

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by urologist and hormone expert Dr. Kelly Casperson for a conversation that challenges conventional thinking about menopause, hormone replacement therapy (HRT), and healthy aging.

Dr. Casperson explains why menopause may be better understood as a form of hypogonadism, shares the story behind the removal of the FDA's black box warning on vaginal estrogen, and explores the latest evidence on estrogen, progesterone, and testosterone therapy for women.

Topics include:
• Vaginal estrogen and the FDA black box warning
• The lasting impact of the Women's Health Initiative (WHI)
• Estrogen, brain health, and mitochondrial function
• Testosterone therapy for women: science and misconceptions
• Hormone therapy after age 60
• Patient education, body literacy, and informed decision-making
• Exercise, sleep, alcohol reduction, and other foundations of healthy aging

Whether you're a functional medicine practitioner or someone interested in menopause, longevity, and women's health, this evidence-based conversation offers practical insights and a fresh perspective on hormone care.

Show notes and references: https://www.drkarafitzgerald.com/fxmed-podcast/

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Kelly Casperson is a board-certified urologic surgeon,CEO and founder of The Casperson Clinic, a modern practice dedicated to hormones and sex medicine, renowned public speaker, sex educator, and host of the top-ranking podcast You Are Not Broken. Dedicated to empowering women, Dr. Kelly blends humor, candor, and science to demystify sexual health, intimacy, and midlife wellness. Through her podcast and online courses, she tackles myths about desire and normalizes conversations around healthy, fulfilling sex. Her work also provides essential education on hormones and midlife health. Connect with Dr. Kelly on Instagram (@kellycaspersonmd) or visit http://kellycaspersonmd.com .

THANKS TO OUR DIAMOND SPONSORS

DUTCH: https://dutchtest.com/for-providers

Biotics Research: https://www.bioticsresearch.com/

Time—Line Nutrition: http://pro.timeline.com/

THANKS TO OUR GOLD SPONSORS

Fullscript Journeys: http://www.fullscript.com/journeys-kara

Equelle: http://equelle.com

CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz

Instagram: https://www.instagram.com/drkarafitzgerald/

Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/

Younger You book: https://tinyurl.com/mr4d9tym

Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Resistance training is one of the most powerful interventions for preserving muscle, supporting metabolic health, and promoting healthy aging—but many patients still find it intimidating or confusing. In this episode, Dr. Kara Fitzgerald sits down with exercise physiologist Brad Currier, PhD, to unpack the newly updated ACSM resistance training guidelines and discuss practical approaches for prescribing exercise across the spectrum, from sedentary adults to elite athletes.

In partnership with Timeline, they also review the latest clinical research on Urolithin A, mitochondrial function, muscle recovery, protein, and creatine, offering actionable insights for functional medicine practitioners.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Brad Currier is Manager of Clinical Trials at Timeline, a Swiss biotech company at the forefront of longevity science for over 15 years. With a background in elite athletics, he went on to earn a PhD in muscle physiology, where his research focused on how exercise and nutrition influence aging and performance.

Brad has led numerous clinical trials conducted around the world and published extensively in peer-reviewed journals. He is also the lead author of the American College of Sports Medicine’s new position stand on resistance training prescription, helping shape global guidelines for strength training and healthy aging.

THANKS TO OUR SPONSOR

TIMELINE: http://Pro.timeline.com

At the core of Timeline is Mitopure®, a pure and patented form of Urolithin A, shown to improve mitochondrial dysfunction. Learn more & Sign up for a Healthcare Practitioner account at http://Pro.timeline.com

Email: care@timeline.com

CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/

Younger You book: https://tinyurl.com/mr4d9tym

Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

In this episode of New Frontiers in Functional Medicine, Richard Horowitz joins Kara Fitzgerald to explore the connection between persistent infections, inflammation, and chronic disease.

The discussion highlights emerging research linking Borrelia burgdorferi (Lyme disease) to amyloid production and Alzheimer’s biomarkers, along with the clinical implications of Dr. Horowitz’s MSIDS model. Topics include biofilm persistence, co-infections, treatment resistance, and multi-targeted strategies for addressing complex, chronic conditions such as Lyme disease, ME/CFS, fibromyalgia, and long COVID.

This episode offers clinicians a more integrated framework for evaluating and managing treatment-resistant patients.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS
Richard Horowitz is a board-certified internist and founder of the Hudson Valley Healing Arts Center. For more than 40 years, he has treated over 13,000 patients with Lyme disease and complex chronic illness using both conventional and integrative approaches.

Dr. Horowitz is the developer of dapsone combination therapy and author of the New York Times bestsellers Why Can’t I Get Better? and How Can I Get Better? His newest book, Ending Chronic Illness, explores how his MSIDS model may apply to many chronic diseases beyond Lyme, offering a broader systems-based framework for diagnosis and treatment.

https://cangetbetter.com/

THANKS TO OUR DIAMOND SPONSORS

Time—Line Nutrition: http://pro.timeline.com/

DUTCH: https://dutchtest.com/for-providers

Biotics Research: https://www.bioticsresearch.com/

THANKS TO OUR GOLD SPONSORS

Equelle: http://equelle.com

Fullscript Journeys: http://www.fullscript.com/journeys-kara

CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz

Instagram: https://www.instagram.com/drkarafitzgerald/

Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/

Younger You book: https://tinyurl.com/mr4d9tym

Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Montel Williams joins Dr. Kara Fitzgerald to share his decades-long journey with multiple sclerosis (MS), including early neurological symptoms that preceded his diagnosis by years and his recovery following a hemorrhagic stroke. In this episode, created in partnership with MitoQ, the conversation explores MS through a functional medicine lens, with a focus on neuroinflammation, oxidative stress, and mitochondrial dysfunction as key drivers of fatigue, cognitive decline, and disease progression.

Clinicians and health-focused listeners will gain insight into how mitochondrial dysfunction impacts energy, recovery, and brain function, along with practical strategies for differentiating emotional lability from depression in MS. The episode also highlights how mitoquinone (MitoQ) may support mitochondrial health as part of a broader, mechanism-based approach to managing MS and other neuroinflammatory conditions.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Montel Williams is an Emmy Award–winning television host, New York Times bestselling author, and health and wellness advocate. A U.S. Navy veteran, he has spent decades educating and inspiring audiences around resilience, longevity, and living well with chronic illness. After being diagnosed with multiple sclerosis (MS) in 1999, Montel adopted a disciplined, science-informed approach to health, emphasizing daily movement, anti-inflammatory nutrition, and integrative care. In addition to his media and writing career, he is actively involved in advancing innovative healthcare solutions, including neuromodulation and trauma-focused therapies.

THANKS TO OUR SPONSOR

This episode is in partnership with MitoQ, a mitochondrial antioxidant designed to support energy production and reduce oxidative stress at the cellular level. Backed by 20+ years of research, MitoQ is formulated to work directly within the mitochondria.

Visit https://www.mitoq.com/ and use code DRKARA15 for 15% off your first order.

CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/

Younger You book: https://tinyurl.com/mr4d9tym

Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw