The Bob Harrington Show

Drs Bob Harrington and Bob Wachter discuss the use of AI in healthcare, and Dr Wachter's latest book, A Giant Leap.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
A Giant Leap. How AI Is Transforming Healthcare and What That Means for Our Future
https://www.penguinrandomhouse.com/books/776443/a-giant-leap-by-robert-wachter-md/
Revisiting the Time Needed to Provide Adult Primary Care
https://doi.org/10.1007/s11606-022-07707-x
Bob Wachter, Digital Doctor Author, Interviewed
https://www.medscape.com/viewarticle/848172
Evidence based medicine: what it is and what it isn't
https://doi.org/10.1136/bmj.312.7023.71
Your A.I. Radiologist Will Not Be With You Soon
https://www.nytimes.com/2025/05/14/technology/ai-jobs-radiologists-mayo-clinic.html
What This Computer Needs Is a Physician: Humanism and Artificial Intelligence https://doi.org/10.1001/jama.2017.19198
Reliability of LLMs as medical assistants for the general public: a randomized preregistered study
https://doi.org/10.1038/s41591-025-04074-y
Expressing stigma and inappropriate responses prevents LLMs from safely replacing mental health providers
https://arxiv.org/abs/2504.18412
Perceptions and Opinions of Patients About Mental Health Chatbots: Scoping Review
https://doi.org/10.2196/17828
User Intentions to Use ChatGPT for Self-Diagnosis and Health-Related Purposes: Cross-sectional Survey Study
https://doi.org/10.2196/47564
KFF Health Misinformation Tracking Poll: Artificial Intelligence and Health Information
https://www.kff.org/public-opinion/kff-health-misinformation-tracking-poll-artificial-intelligence-and-health-information/
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078
Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546
Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands
https://doi.org/10.1080/13814788.2017.1398318
Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study
https://doi.org/10.1002/epd2.20253
Traumatic Brain Injury and Risk of Neurodegenerative Disorder
https://doi.org/10.1016/j.biopsych.2021.05.025
Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence
https://doi.org/10.3390/ijms222413488
The neuropathological diagnosis of Alzheimer's disease
https://doi.org/10.1186/s13024-019-0333-5
Failed Semaglutide for Early Alzheimer's Not the End of the Road?
https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l
Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration
https://doi.org/10.1161/circulationaha.121.055018
Reduced regional cerebral blood flow in patients with heart failure
https://doi.org/10.1002/ejhf.874
Heart-brain Interactions in Heart Failure
https://doi.org/10.15420/cfr.2018.14.2
While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work
https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb
Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder
https://doi.org/10.1001/jamapsychiatry.2024.3599
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356
"VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593
Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299
Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
New ACS Guidelines
2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
https://doi.org/10.1161/CIR.0000000000001309
ACS Guideline Chair and Vice-Chair Discussion
https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l
Antiplatelet/Antithrombotic Strategies
Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI
https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507980
Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis
https://doi.org/10.1016/j.jacadv.2025.102504
Factor XI Inhibitors
Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review
https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu
Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke
OAC-Naive Subgroup From OCEANIC-AF Published
https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz
GLP-1 and Myotrophic Drugs
Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4)
https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1
Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial
https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf
CRISPR and Lipid Lowering
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
https://www.nejm.org/doi/full/10.1056/NEJMoa2504747
Gene Therapy Shows Lipid Improvement but Raises Flags
https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3
https://www.nejm.org/doi/full/10.1056/NEJMoa2511778
Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV)
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428
Prehospital GLP IIb/IIIa
Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
https://doi.org/10.1161/CIR.0000000000001078
Development and Validation of the American Heart Association's PREVENT Equations
https://doi.org/10.1161/CIRCULATIONAHA.123.067626
C-Reactive Protein and Cardiovascular Risk Among Women With No Standard Modifiable Risk Factors: Evaluating the 'Smurf-Less but Inflamed'
https://doi.org/10.1093/eurheartj/ehaf658
Mortality in STEMI Patients Without Standard Modifiable Risk Factors: A Sex-Disaggregated Analysis of SWEDEHEART Registry Data
https://doi.org/10.1016/S0140-6736(21)00272-5
Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women
https://www.nejm.org/doi/10.1056/NEJMoa2405182
Statins for the 'SMuRFLess But Inflamed': Silent Vascular Inflammation and the Challenge of Translational Science
https://doi.org/10.1016/j.jacbts.2025.101318
VERVE-101: A Promising CRISPR-Based Gene Editing Therapy That Reduces LDL-C and PCSK9 Levels in HeFH Patients
https://academic.oup.com/ehjcvp/article/10/2/89/7492807
You may also like:
Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Cardiologist and author Eric Topol discusses the science of longevity, why the key to healthy aging is prevention, and the perils of a fixation on reversing ageing.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Super Agers: An Evidence-Based Approach to Longevity
https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
Wellderly study
https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/
Lotte Bjerre Knudsen
https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist
Organ aging signatures in the plasma proteome track health and disease
https://doi.org/10.1038/s41586-023-
Deep Medicine
https://drerictopol.com/portfolio/deep-medicine/
You may also like:
Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]