The Machine Learns Medicine: Daphne Koller’s Vision for AI in Biotech
Daphne Koller, CEO of insitro and cofounder of Coursera, joins Leadership Next to unpack a bold idea: Just as calculus revolutionized our understanding of physics, AI could do the same for biology. In this episode, Koller explains how insitro is blending biology and machine learning to unlock new treatments for diseases like ALS and fatty liver. She also opens up about her leap from academia to entrepreneurship, the ethical challenges of data collection, and why the future of medicine lies in personalized, AI-driven care. Plus, her take on why humans and machines must work in tandem to drive meaningful innovation.
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Home Truths: Inside the Future of Real Estate With the CEO of Zillow
Zillow CEO Jeremy Wacksman joins Leadership Next to unpack the forces reshaping American real estate—and the friction threatening its transparency. In a wide-ranging conversation, Wacksman addresses the industry lawsuit brought by Compass and defends Zillow’s stance on keeping property listings open and accessible to all. He explains how the current system—a uniquely American one that allows any buyer or agent to view every listing—is now at risk.With home prices nearly doubling since the pandemic and affordability out of reach for many millennials and Gen Z buyers, Wacksman outlines how Zillow is leaning into AI, computer vision, and immersive virtual experiences to create “super listings” that streamline the buying process. He also shares Zillow’s strategy for supporting buyers long before they’re ready to transact, highlighting the role of casual browsing in shaping the future of homeownership.Wacksman discusses the emotional weight of buying a home, why nearly half of buyers report crying during the process, and how Zillow is building tools to ease the burden. He also opens up about the company’s remote-first culture, the power of retreats to foster creativity, and why he champions a “career jungle gym” over a traditional ladder.
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Brian Moynihan on Leading Bank of America with Calm, Purpose, and AI
Brian Moynihan, CEO of Bank of America, joins Leadership Next to reflect on his journey from law to banking—and how that unexpected pivot brought him to the head job at one of the world’s largest financial institutions. He shares his leadership philosophy, emphasizing the power of staying calm in a crisis and the importance of giving energy to his team, not taking it away.
Moynihan discusses Bank of America's strategic shift from aggressive acquisitions to organic growth, fueled by major investments in technology—like the AI assistant Erica. He explains why Erica is evolving from “third-grade Einstein” to near-genius capabilities.
He also shares his perspective on responsible capitalism, the importance of expanding opportunities for underserved communities, and how he's preparing the bank for its next generation of leaders.
Tune in to hear Moynihan's take on what it means to wear responsibility like a “comfortable sweater”—and how corporate leaders can help combat hate and promote dignity in today’s world.
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Leading the Built World: Michelle MacKay on Innovation in Real Estate
Michelle MacKay, CEO of Cushman & Wakefield, doesn’t see the company as just a real estate firm—she sees it as an architect of the built world. In this episode of Leadership Next, she joins us to discuss the evolving definition of commercial real estate and Cushman & Wakefield’s expansive global strategy, from solar installations to hospital management. Michelle reflects on her unconventional path from political science to the C-suite, her “filters-off” approach to hiring, and the lessons boardrooms have taught her about resilience. She also breaks down why adaptability is crucial in cities like New York and Singapore, how AI is reshaping the future of the industry, and why she’s placing big bets on underdog markets like Baltimore and St. Louis.
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Hacking the CEO Job: Drew Houston on Reinvention and Leadership
In this episode, Dropbox founder and CEO Drew Houston joins Leadership Next to share how he's reimagining work in the age of AI. He traces Dropbox’s evolution—from solving file-syncing in the early cloud era to launching Dropbox Dash, a new AI-powered search and knowledge-management tool. Houston reflects on the hard lessons from failed ventures into email and photo apps, the pressures of self-disruption, and what it takes to stay relevant in a crowded productivity space. He also opens up about distributed work, leadership growth, and the books and mentors that have shaped his journey toward becoming a “bionic CEO.”
Something big is happening in the world of business. CEOs increasingly say their jobs have become less about giving orders, more about inspiring, motivating, setting a north star. They are taking the lead on big issues like climate change, worker retraining, and diversity and inclusion. They are under pressure from employees, customers and investors not just to turn a profit, but to prove they are doing good in the world. And in the process, they are fundamentally redefining the relationship between business and society. Join Fortune Executive Editorial Director Diane Brady and Editorial Director Kristin Stoller as they engage global leaders on the insights, experiences and issues you need to know.
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