Metabolic Mind

• New Study Using CGMs Reveals Surprising Truth About Your Blood Sugar

  Did you know that your blood sugar spikes differ from everyone else's? Even with the same food!A new study in Nature Medicine supports what many have long suspected: there is no one-size-fits-all diet. The foods that spike your blood sugar might not affect someone else the same way, and your unique metabolic profile could be the reason why.In this episode of the Metabolic Mind podcast, Baszucki Group Neuroscience Program Officer Dr. Cristina Nigro joins Dr. Bret Scher to break down the study “Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology.” This research used continuous glucose monitors (CGMs) to track how different individuals respond to carbohydrate-rich foods, and the results are eye-opening.📌 In this conversation, you’ll learn:Which carb-containing foods were tested in the study.Why some people were labeled “potato spikers” or “grape spikers.”The importance of insulin sensitivity and resistance in mitigating glucose responses.How fiber, fat, and protein consumed before a meal can blunt sugar spikes—for some people.The role of CGMs in personalizing treatments for chronic diseases, including severe mental illness.How this data could inform future dietary guidelines and chronic disease treatment.It’s time to recognize that we are all unique individuals down to the cellular level and our differences mean there may be unique requirements for each of us to maintain and improve health. Tools like CGMs offer powerful insight into how your body truly responds to food, and that information can be pivotal for tailoring interventions in chronic diseases, including serious mental illnesses. We are hopeful that research like this will lead to better treatment protocols and dietary guidelines.Expert Featured:Cristina NigroLinkedIn: https://www.linkedin.com/in/cristina-nigro-19394127/Resources Mentioned:Individual variations in glycemic responses to carbohydrates and underlying metabolic physiologyhttps://www.nature.com/articles/s41591-025-03719-2#Sec2CMEs Mentioned:Managing Major Mental Illness with Dietary Change: The New Science of Hopehttps://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illnesshttps://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/

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• She Cured 5 Mental Illnesses in 12 Weeks

  Can ketogenic therapy help treat multiple mental health disorders at once? In this video, we explore a dramatic case report where ketogenic therapy put bipolar depression, binge eating disorder, anxiety, PTSD, and ADHD into remission. Clinical psychologist Dr. Erin Louise Bellamy joins Dr. Bret Scher to discuss her recently published case report of a 38-year-old woman whose life went from “a mind shattered now restored” in just 12 weeks on a medically supervised ketogenic therapy program. Results so impressive that it forced other practitioners to dismiss the results as being “clinically improbable.” In this interview, we cover:- How achieving higher therapeutic ketone levels impacted her mental health symptoms- How they tailored her diet to achieve a level of ketosis that kept her symptoms in remission- Why ketogenic therapy may target shared mechanisms across psychiatric diagnoses- The concept of trans-diagnostic remission and treating root causes, not just symptoms- The role of dietary compliance, food addiction awareness, and tailored guidance- How ketogenic therapy can work alongside medications or as a primary intervention for some patientsWhile the results from this case report may seem out of this world, again and again we are seeing ketogenic therapy provide impressive levels of relief for individuals who are really struggling with mental illness. We hope that these stories will reset the expectations for what is possible in psychiatric care. #MetabolicMind #KetogenicTherapy #MentalHealth #Psychiatry #BipolarDisorder #PTSD #ADHD #Anxiety #BingeEatingDisorder #NutritionAndMentalHealthExpert Featured:- Dr. Erin Louise Bellamy - Website: ikrt.org- X: https://x.com/erinlbellamy- Instagram: https://www.instagram.com/erinlouisebellamy/?hl=enResources Mentioned:Transdiagnostic remission of psychiatric comorbidity in post-traumatic stress disorder, ADHD, and binge-eating disorder using ketogenic metabolic therapy: a retrospective case reporthttps://www.researchgate.net/publication/392930410_Transdiagnostic_remission_of_psychiatric_comorbidity_in_post-traumatic_stress_disorder_ADHD_and_binge-eating_disorder_using_ketogenic_metabolic_therapy_a_retrospective_case_reportFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/

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• This Molecule Might Be the Key to Beating Addiction

  Can adenosine and a ketogenic diet help treat addiction? New research explores the powerful role of adenosine, dopamine, and metabolic health in addiction, and how dietary strategies could support recovery.In this interview, Dr. Bret Scher speaks with Dr. Susan Masino, a neuroscience and psychology professor at Trinity College, about her groundbreaking work on adenosine and its potential to regulate addiction through metabolic pathways. They dive into:The dopamine-addiction connectionThe role of adenosine in addiction and how it balances dopamine activityThe role of ketogenic diets in boosting adenosineOther mechanisms supporting keto for treating addictionWhy food, sugar, and even phone addiction may share common rootsHow metabolic therapies could support recovery from addiction, depression, and moreDr. Masino also shares insights on how habits, stress, inflammation, and neuroplasticity all intersect with metabolic health—and what that means for mental health and addiction treatment going forward.Expert Featured:Dr. Susan Masinohttps://internet3.trincoll.edu/facprofiles/default.aspx?fid=1117011Resources Mentioned:Ketogenic diet, adenosine, and dopamine in addiction and psychiatryhttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1492306/fullFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

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• The Truth About Tapering Off Psychiatric Medications

  Have you ever thought about stopping psychiatric medications? Maybe you have tried it.If so, you’re not alone. Many individual across the world have considered or tried stopping their psychiatric medications and success is variable.The withdrawal from psychiatric medication tapering can be incredibly complex, and doing it safely requires both medical and psychological support.But, as Dr. Anders Sørensen highlights in this interview, the guidelines around medication tapering and withdrawal miss a lot of important nuances that can prevent people from being successful.In this interview, psychologist and PhD researcher Dr. Anders Sørensen shares his decade-long experience helping people taper off psychiatric medications. He covers the biological and emotional aspects of withdrawal, the science behind tapering strategies like hyperbolic tapering, and why psychotherapy plays a vital role during and after the process. You'll also learn how short-term clinical studies shaped medical guidelines and why those guidelines may not reflect the lived experience of long-term patients.In this video, you'll also learn:Why withdrawal can feel like relapse—and how to tell the differenceWhat makes tapering more complex than just reducing the doseHow to understand withdrawal symptoms and avoid severe outcomesWhy “tapering to something” (like therapy or metabolic interventions) mattersHow psychotherapy can support emotional reintegration once medications are goneWatch for Dr. Sørensen’s forthcoming book “Crossing Zero: The Art and Science of Coming and Staying Off Psychiatric Drugs” coming in summer 2025.Expert Featured:Dr. Anders SørensenX: https://x.com/_AndersSorensenSubstack: https://crossingzero.substack.com/Book Coming Soon: https://crossingzero.substack.com/p/curious-about-the-bookResources Mentioned:Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic reviewhttps://pubmed.ncbi.nlm.nih.gov/35173954/Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

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• What’s the connection between Depression, antipsychotics, and suicide risk?

  Is it really treatment-resistant depression or are we using the wrong treatments?In this episode, Dr. Bret Scher is joined by psychiatrist Dr. Georgia Ede to examine a new large, population-based analysis on the use of antipsychotics versus third-line antidepressants in people diagnosed with treatment-resistant depression, and what effect that has on suicide risk.They discuss:What treatment-resistant depression actually meansWhy so many people fall into this categoryThe surprising data on suicide risk and all-cause mortalityThe metabolic side effects of antipsychotic medicationsAlternative options beyond antipsychotics—including ketogenic therapy and other metabolic strategiesThis conversation explores why conventional approaches may fall short, and how metabolic psychiatry offers promising, low-risk alternatives.📌 Please note: This episode discusses suicide and may be triggering for some viewers.Expert Featured:Dr. Georgia Ede, MDhttps://www.linkedin.com/in/georgiaedemd/https://www.instagram.com/georgiaedemd/?hl=enhttps://x.com/georgiaedemdResources MentionedAntipsychotic therapy and suicide risk in patients with treatment-resistant depression: target trial emulation framework studyhttps://doi.org/10.1192/bjp.2024.283CMEs Mentioned:Managing Major Mental Illness with Dietary Change: The New Science of Hopehttps://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illnesshttps://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

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