eanCast: Weekly Neurology

Moderator: Gabriela Rusin (Kraków, Poland) Guest: Jakub Antczak (Kraków, Poland) In this episode, Gabriela Rusin speaks with Jakub Antczak about non-invasive neuromodulation in neurology. They outline the principles of transcranial magnetic stimulation and transcranial electrical stimulation, emphasizing their role in modulating brain plasticity in network-based neurological disorders. The discussion reviews current clinical evidence across conditions such as stroke, neurodegenerative diseases, neuropathic pain, and Parkinson’s disease, highlighting variability in treatment response and key limitations. They also address practical considerations for clinical use, the importance of patient selection and combination with rehabilitation, and emerging techniques aimed at improving targeting and personalisation.

Moderator: Gabriela Rusin (Kraków, Poland) Guest: Jakub Antczak (Kraków, Poland) In this episode, Gabriela Rusin speaks with Jakub Antczak about the role of nerve ultrasound in neuromuscular diagnostics. The growing popularity of this method is rapidly transforming the field of neurology. In combination with nerve conduction studies and electromyography, it provides insight into both the function and the structure of peripheral nerves. They discuss the technical foundations of neuromuscular ultrasound as well as key clinical indications (neuropathies, trauma, plexopathies, root lesions, etc.) and real-world applications. Prof. Antczak shares his experience and practical tips for clinicians interested in incorporating peripheral nerve ultrasound into their practice.

Moderator: Caterina Leone (Rome, Italy) Guest: Andrea Truini (Rome, Italy) In this episode, Caterina Leone speaks with Andrea Truini about small fibre neuropathy, a frequently under-recognised condition with a significant impact on patients’ quality of life. They discuss key clinical features, including neuropathic pain and autonomic symptoms, and explain why routine nerve conduction studies are often normal. The conversation highlights the role and limitations of skin biopsy and functional testing, the importance of identifying underlying causes, and practical approaches to diagnosis and management with realistic treatment expectations.

Moderator: Rob Hadden (London, United Kingdom) Guest: Claudia Sommer (Würzburg, Germany) In this episode, Rob Hadden and Claudia Sommer discuss ongoing challenges in treating CIDP. While most patients benefit from current therapies, some remain treatment-refractory, driving the need for innovation. They highlight emerging response definitions, promising FcRn and complement inhibitors, and the importance of individualized care and serum biomarkers for improving patient outcomes. This episode has been supported by an educational grant from argenx. The programme has not been influenced in any way by its supporter.

Moderator: Yilidz Degirmenci (Istanbul, Türkiye) Guest: Hanneke Hulst (Auckland, New Zealand) In this episode, Yıldız Değirmenci speaks with Hanneke Hulst about cognitive problems in multiple sclerosis, an often invisible but highly disabling aspect of the disease. They discuss how common cognitive impairment is in MS, the domains most frequently affected, particularly information processing speed and memory, and the underlying white and gray matter pathology. The conversation highlights the real-world impact on work, relationships, and quality of life, as well as practical strategies for early detection, screening, and cognitive support in clinical practice.