Dementia Matters

What if your heartbeat could help determine your dementia risk? The CAIDE dementia risk score has long helped clinicians estimate midlife risk for dementia using cardiovascular health factors, but its accuracy hasn’t been equal across populations. New research suggests that integrating resting heart rate meaningfully improves predictive performance across most racial groups. In this interview, Dr. Newman Sze and Shakiru Alaka join us to dig into how and why resting heart rate enhances CAIDE’s accuracy, what the data shows across different racial groups, and what this could mean for earlier, more equitable identification of dementia risk in both research and clinical settings.

Guests: Newman Sze, PhD, professor of health sciences, Brock University, Canada Research Chair in Mechanisms of Health and Disease, and Shakiru Alaka, MS, senior analyst, Canadian Institute for Health Information, data scientist, Western University

Show Notes
Read Shakiru and Dr. Sze’s study, “Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities,” published in Alzheimer’s & Dementia online.

Learn more about Shakiru and Dr. Sze’s research from this article on the Brock University website.

Learn more about Dr. Sze and his research from his bio on the Brock University website.

Look into more of Shakiru’s research from his Google Scholar page.

Connect with us
Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia, out June 2, 2026.

What if one of the most powerful clues about dementia risk is already being captured every morning before you even get out of bed? The CAIDE dementia risk score has long helped clinicians estimate midlife risk for dementia using cardiovascular health factors, but its accuracy hasn’t been equal across populations. New research suggests that integrating resting heart rate meaningfully improves predictive performance across most racial groups. In this interview, Dr. Newman Sze and Shakiru Alaka join us to dig into how and why resting heart rate enhances CAIDE’s accuracy, what the data shows across different racial groups, and what this could mean for earlier, more equitable identification of dementia risk in both research and clinical settings.

Guests: Newman Sze, PhD, professor of health sciences, Brock University, Canada Research Chair in Mechanisms of Health and Disease, and Shakiru Alaka, MS, senior analyst, Canadian Institute for Health Information, data scientist, Western University

 

Show Notes
Read Shakiru and Dr. Sze’s study, “Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities,” published in Alzheimer’s & Dementia online.

Learn more about Shakiru and Dr. Sze’s research from this article on the Brock University website.

Learn more about Dr. Sze and his research from his bio on the Brock University website.

Look into more of Shakiru’s research from his Google Scholar page.




Connect with us
Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia, out June 2, 2026.

Alzheimer’s disease isn’t always the only health condition a person faces, so how does treating other diseases impact the progression of Alzheimer’s? Researchers at the University of Arizona focused on four common health conditions – type two diabetes, hypertension, inflammation and dyslipidemia – which are known to increase the risk of developing Alzheimer’s disease, and set out to investigate whether those diagnosed with Alzheimer’s who received treatments for these four conditions also saw a delay in cognitive decline. Dr. Barb Bendlin joins the podcast to break down the findings from this research, as well as discuss the impact of personalized prevention strategies and combination therapies.

Guest: Barbara Bendlin, PhD, professor, Division of Geriatrics and Gerontology, University of Wisconsin (UW) School of Medicine and Public Health, deputy director, UW Center for Health Disparities Research (CHDR)

Show Notes
Read the study, “Combination therapy targeting Alzheimer's disease risk factors is associated with a significant delay in Alzheimer's disease–related cognitive decline,” published by Alzheimer's & Dementia: Translational Research & Clinical Interventions on the Alzheimer’s Association’s website. 

Read more about the study in the article “Four Key Pieces Managing Common Health Conditions Slows Alzheimer's Progression,” published on the National Alzheimer’s Coordinating Center’s website.

Learn more about Dr. Bendlin from her profile on the UW Center for Health Disparities Research website.

Connect with us
Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

Learn about and pre-order Dr. Chin’s book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia, out June 2, 2026.

10,000 – that’s the magic number of steps often recommended for a healthy lifestyle. With recent research looking into whether that number is an accurate benchmark for health, could the number of steps taken per day have an impact on brain health and, specifically, cognitive decline? That’s precisely what a new study from Harvard Medical School and Mass General Brigham sought to examine, looking at how physical activity, specifically step count, impacted cognitive decline for those living with Alzheimer’s disease. Dr. Bri Breidenbach and Sarah Lose join the podcast to break down the results of this new study, as well as share what current research says about the effect of other kinds of physical activity, such as different intensity exercises, on the brain and Alzheimer’s progression.

Guests: Bri Breidenbach, PhD, scientist, exercise physiologist, Okonkwo Lab, and Sarah Lose, MS, research program manager, exercise physiologist, Okonkwo Lab, UW School of Medicine and Public Health

Show Notes
Read the study, “Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease,” published by the journal Nature Medicine on their website.

Learn more about Dr. Breidenbach and Sarah Lose’s work on the Okonkwo Lab website.

Read “Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK,” mentioned by Dr. Breidenbach at 12:01, on JAMA Neurology’s website.

Listen to Sarah Lose’s previous episode, “Building the Brain: Finding the Cognitive Benefits of Physical Activity,” on our website.

Learn more about physical activity and the six pillars of brain health on our website.

Complete the Dementia Matters Feedback Survey to let us know what our show is doing well and how we can improve in the New Year! This anonymous survey is estimated to take about 5 minutes to complete and is open to all.

 

Connect with us
Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.

As 2025 comes to an end, host Dr. Nathaniel Chin discusses the importance of gratitude for brain health and shares what he’s grateful for from this past year.

Show Notes
Complete the Dementia Matters Feedback Survey to let us know what our show is doing well and how we can improve in the New Year! This anonymous survey will be open until January 14th, 2026 and is estimated to take about 5 minutes to complete.

Read the study Dr. Chin mentions at 0:57, “Association between gratitude, the brain and cognitive function in older adults: Results from the NEIGE study,” on the ScienceDirect website.

Connect with us
Find transcripts and more at our website.

Email Dementia Matters: [email protected]

Follow us on Facebook and Twitter.

Subscribe to the Wisconsin Alzheimer’s Disease Research Center’s e-newsletter.

Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer’s. All donations go toward outreach and production.