Medical Digest & Congress Report

Professor Daisy Acosta delivers an essential expert overview on the shifting landscape of dementia prevalence across Latin America, building on crucial insights from the 10/66 studies. This concise brief highlights the unexpected increase in dementia prevalence over the past two decades across multiple catchment sites, contrasting sharply with the declining trends observed in high-income countries. Professor Acosta underscores the growing and uneven burden facing the region, outlining a critical roadmap that emphasizes the urgent need for strengthened surveillance, targeted risk reduction strategies, and substantial infrastructure investment to control modifiable risk factors and prevent dementia before it overwhelms healthcare systems.
Video: https://medicaldigest.org/scientific-contents/interview:control-modifiable-risk-factors-prevent-dementia-insights-1066-studies

Professor Takaomi C. Saido, world renowned scientist, delivers a comprehensive expert overview on the current state of Alzheimer's disease research, moving past traditional models to explore groundbreaking therapeutic targets. This concise brief highlights the mechanisms behind approved disease-modifying therapies, the crucial role of neprilysin and somatostatin receptor in amyloid clearance, and the development of next-generation knock-in mouse models mapping the complex amyloid-tau pathology pathways. Professor Saido outlines a visionary roadmap toward preventing Alzheimer's before the clinical onset of cognitive impairment.
Video: https://medicaldigest.org/scientific-contents/interview:new-landscape-alzheimers-therapy-targets-treatments-and-future-outlook

Dr. James Douketis delivers an essential overview of the key highlights from the newly updated ISTH guidelines and guidance documents at the ISTH 2026 Congress. This targeted brief focuses on practical, evidence-based clinical recommendations, highlighting two major clinical updates:
Surgical and Procedural Bleed Risk Stratification for Anticoagulated Patients Undergoing Planned Surgery – A refined, three-tier classification framework to optimize periprocedural anticoagulation management.
Monitoring and Management of Therapeutic-dose UFH in Practice – Key updates on standardizing and improving the safety of therapeutic unfractionated heparin (UFH) dosing and monitoring.
Video: https://medicaldigest.org/scientific-contents/interview:highlights-isth-guidelines-and-guidance-documents

Dr. Zsuzsanna Bagoly presents the highly anticipated updated clinical recommendations for the diagnosis and classification of Factor XIII (FXIII) deficiencies at the ISTH 2026 Congress. This essential brief outlines the revised diagnostic algorithms, standardized laboratory assays, and clear classification pathways designed to improve the detection and management of this underdiagnosed, life-threatening bleeding disorder.
Video: https://medicaldigest.org/scientific-contents/interview:updated-recommendations-diagnosis-and-classification-fxiii-deficiencies-isth-2026-diagnostic-highlights

Dr. Marco Donadini highlights the next generation of antithrombotic therapies at the ISTH 2026 Congress, featuring these breakthrough presentations:

- A Synthetic, Allosteric, Highly Selective, Reversible Inhibitor of Human Factor XIa for Venous and Lung (Cancer-Associated) Thrombosis – Umesh Desai (Richmond, US)

- EXocite ACTive site (EXACT) Inhibitors as Potent RNA Aptamer-Based Anticoagulants Targeting Various Coagulation Factors – Jeffrey Clancy (Durham, US)

- Efficacy-Safety Paradox of Next-Gen Factor XI/XIa Inhibitors: Meta-Analysis of Phase 2 and 3 Trials – Rahul Falodia (Jodhpur, India)

- BAY 3389934: A Dual Factor IIa/Xa Inhibitor – Nicole Juffermans (Rotterdam, The Netherlands)

- REGN9533, a monoclonal antibody targeting Factor XII (FXII), Phase 1 study – Frédéric Vanhoutte (Antwerp, Belgium)
Video: https://medicaldigest.org/scientific-contents/interview:future-anticoagulants